Thymic-derived CD25 + CD4 T regulatory cells (Tregs) suppress immune responses, including transplantation. Here we evaluated the ability of dendritic (DCs) to expand alloantigen-specific Tregs in mixed leukocyte reaction (MLR) that develops from polyclonal populations cells. The allogeneic DCs, when supplemented with IL-2 cultures, were much more effective than bulk spleen expanding numbers Tregs. Likewise, DCs and not sustaining expression transcription factor Foxp3 Tregs, but neither nor...

A systemic proinflammatory response has been implicated in the pathogenesis of organ dysfunction. The effects surgery, surgical stress, anesthesia, and subsequent intensive care unit (ICU) resuscitation may affect components inflammatory syndrome (SIRS) score (temperature, heart rate, respiratory white blood cell count). Any SIRS scores calculated within 24 hours after surgery or at onset nonoperative overestimate itself, making quantitation that time potentially too sensitive. We...

Objective There is disagreement over the reliability of technetium Tc 99m (99mTc)-labeled erythrocyte scintigraphy in localization active lower gastrointestinal hemorrhage. A previous study at The New York Hospital-Cornell Medical Center that showed a superior sensitivity for versus angiography surgical patients led authors to emphasize as diagnostic test first choice clinical algorithm. hypothesized tagged can be used accurately primary modality localizing acute bleeding and guiding...

We have defined conditions for generating large numbers of dendritic cells (DC) in marrow cultures from 10 – 12-week-old ACI or WF rats. The combination granulocyte-macrophage colony-stimulating factor (GM-CSF) and TNF-α, known to induce DC human CD34+ progenitors, was not effective with rat. In contrast, GM-CSF plus IL-4 generated high yield, corresponding 30 40 % the initial number plated cells. proliferated distinctive aggregates, which most had an immature phenotype marked by...

Nipple-sparing mastectomy performed via an inframammary fold incision with implant-based reconstruction is oncologically safe procedure that provides excellent cosmesis.The authors report their experience conservative treatment of postoperative nipple-areolar complex (NAC) ischemia and analysis risk factors for NAC failure.A retrospective chart review was conducted 318 nipple-sparing mastectomies through incisions between July 2006 October 2012. dressings consisted topical nitroglycerin,...

Background: A tumor-to-nipple distance of greater than 2 cm has traditionally been considered a criterion for nipple-sparing mastectomy. This study evaluates whether magnetic resonance imaging and sonographic measurements accurately reflect the risk nipple involvement by disease. Methods: All mastectomy cases with implant-based reconstruction performed senior author between July 2006 December 2014 were retrospectively reviewed. Therapeutic preoperative or sonography included. Results: One...

Background: Surgical protocols for hallux valgus (HV) surgery rely on the severity of deformity, utilizing various techniques different grades. The purpose this study was to evaluate association between extent distal fragment translation and patient-reported outcome measures (PROMs) in patients with HV varying grades who had undergone same surgery, a minimally invasive chevron Akin (MICA) procedure, at least 50%. Methods: We conducted retrospective MICA procedure January 1, 2017, August...

Background: This article discusses the senior author’s (M.T.) experience with nipple-areola complex malposition following nipple-sparing mastectomy, surgical options for treatment, and an analysis of risk factors. Methods: A retrospective review was conducted on a prospectively collected institutional board–approved database mastectomy cases immediate device-based reconstruction performed between July 2006 October 2012. Malposition graded as mild (1 cm), moderate (2 or severe (>3 cm)...

The use of highly active antiretroviral therapy (HAART) with protease inhibitors can result in a syndrome peripheral wasting, facial fat atrophy, and central adiposity as many 64% patients infected human immunodeficiency virus (HIV) who are treated this regimen for 1 year. In study the authors evaluated 9 consecutive presented disease to define further its anatomic features explore techniques surgical correction. Three these severe underwent exploration reconstruction submalar silicone...

In Brief Plastic surgeons frequently administer botulinum toxin A (Botox) or collagen as monotherapy to treat glabellar furrows. This study evaluates the possible advantages of combination therapy. Sixty-five patients with moderate severe rhytids were prospectively randomized receive standard injections Botox, Zyderm II collagen, a combination. Improvement in was assessed over 3 months using patient satisfaction scores and an independent physician evaluation. Baseline wrinkle severity...

Nipple-sparing mastectomy through an inframammary fold incision (NSM-IMF) with implant-based reconstruction (IBR) is a cosmetically preferable approach to breast cancer treatment in appropriate candidates. However, patients who have undergone prior cosmetic surgery (CBS) may be at increased risk for postoperative complications secondary existing surgical scars. To assess whether CBS increases the of following NSM-IMF IBR. A retrospective chart review was conducted 398 NSM-IMFs IBR performed...

Squamous cell carcinoma of the breast is an extremely rare neoplasm. Approximately 50 cases have been reported in English literature since 1917. The pathogenesis squamous puzzling because epithelial elements are not normally identified tissue. It has suggested that cells derived from epidermoid cysts deposited during early embryological development, metaplastic transformation ductal cells, or after trauma surgical manipulation. Although no evidence published to support a causal relationship...

In the United States, inferior pedicle Wise pattern technique of reduction mammaplasty has been well established as a safe and reliable method reducing breast size while maintaining nipple-areolar vascularity sensation. Nonetheless, typical inverted-T scar is consistent source patient surgeon dissatisfaction with operation, which led to increased popularity limited-incision techniques reduction.In this study, it was our goal evaluate preferences for location.A retrospective chart review...

Nipple-sparing mastectomy (NSM) through an inframammary fold (IMF) incision can provide superior cosmesis and a high level of patient satisfaction. Because concerns for nipple-areolar complex (NAC) viability using this incision, selection criteria may be limited. Here, we evaluate the impact scarring from prior lumpectomy on NAC viability.A retrospective chart review was conducted prospectively collected database at single institution between July 2006 October 2012. A total 318 NSMs IMF...

Introduction Oncoplastic breast reduction has been shown to be an effective approach conservation surgery in women with macromastia. Clear surgical margins can achieved while simultaneously improving symptomatic macromastia and enhancing aesthetic outcomes. Little written about postoperative complications after this procedure, beyond the risk of locoregional recurrence. This study aimed compare complication profile for oncoplastic versus benign Methods A retrospective review our experience...

Occult nipple malignancy is detected in 0% to 58% of attempted nipple-sparing mastectomies (NSM), prompting excision the nipple. We report our experience with resection following NSM and outcomes subsequent reconstruction.An institutional review board-approved retrospective was performed cases immediate implant-based reconstruction from July 2006 April 2015. Patients who underwent were identified. Indications for excision, pathology reports, reconstructive reviewed.Five hundred sixty-eight...

Talmor, Mia M.D.; Fahey, Thomas J. II Wise, Jeffrey B.A.; Hoffman, Lloyd A. Barie, Philip S. M.D., F.C.C.M. Author Information