A5052912482- Cellular Mechanics and Interactions
- Breast Lesions and Carcinomas
- Advanced Biosensing Techniques and Applications
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray Imaging Techniques
- Advanced MRI Techniques and Applications
- AI in cancer detection
- Digital Radiography and Breast Imaging
- Photoacoustic and Ultrasonic Imaging
- Breast Cancer Treatment Studies
- Advanced X-ray and CT Imaging
- Optical measurement and interference techniques
- Force Microscopy Techniques and Applications
- Global Cancer Incidence and Screening
- Cancer Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Cancer Risks and Factors
- Bladder and Urothelial Cancer Treatments
- thermodynamics and calorimetric analyses
- Surgical Simulation and Training
- Phonocardiography and Auscultation Techniques
- Ultrasound Imaging and Elastography
- Peripheral Artery Disease Management
- X-ray Spectroscopy and Fluorescence Analysis
Kantonsspital Baden
2017-2024
University Hospital of Basel
2017-2018
University of Basel
2017-2018
University of North Carolina at Chapel Hill
1992
Grating-interferometry-based mammography (GIM) might facilitate breast cancer detection, as several research works have demonstrated in a pre-clinical setting, since it is able to provide attenuation, differential phase contrast, and scattering images simultaneously. In order translate this technique the clinics, has be adapted cover large field-of-view within clinically acceptable exposure time radiation dose.We set up grating interferometer that fits into standard system fulfilled...
Non-mass enhancement (NME) in breast MRI is the most common feature of ductal carcinoma situ (DCIS). We sought to evaluate interobserver variability and positive predictive value (PPV) for malignancy NME descriptors using fifth edition BI-RADS lexicon focusing on newly introduced "clustered ring enhancement" pattern.Breast MRIs 129 patients who had undergone MRI-guided vacuum-assisted biopsy (VAB) our institution were reviewed. Studies assessed as classified according by two radiologists....
The superparamagnetic iron oxide tracer Sienna+® was introduced as an alternative to the radioisotope 99Tc Nanocoll preoperatively mark sentinel lymph nodes in breast cancer. As previously reported, this causes susceptibility artifacts on magnetic resonance imaging (MRI), potentially hampering diagnostic performance of follow-up MRI. This short report illustrates temporal development these a patient who followed up at 6, 12, and 18 months after administration with MRI systems different field...
Abstract To investigate changes in breast density (BD) during the menstrual cycle young women comparison to inter-breast and -segment as well reproducibility of a novel Speed-of-Sound (SoS) Ultrasound (US) method. SoS-US uses conventional US system with reflector software add-on quantify SoS retro-mammillary, inner outer segments both breasts. Twenty healthy (18–40 years) regular cycles were scanned twice two weeks in-between. Three these additionally measured per week for 25 days. Average...
Grating interferometry mammography (GIM) is an experimental breast imaging method at the edge of being clinically implemented. Besides attenuation, GIM can measure refraction and scattering x-rays resulting in differential phase contrast (DPC) dark-field (DF) images. In this exploratory study, we assessed feasibility using microbubbles as a agent GIM. Two millilitres iodine were respectively injected into ex vivo phantoms, consisting fresh chicken breasts. Native postcontrast images acquired...
To describe the clinical set-up and evaluate feasibility of multimodal ultrasound tomography (MUT) for breast imaging.Thirty-two consecutive patients referred imaging 24 healthy volunteers underwent MUT. In 32 patients, examination discomfort was compared to that mammography (n = 31), handheld (HUS) 27) magnetic resonance (MRI) 4) on a scale from 1 (lowest discomfort) 10 (highest discomfort). MUT investigation time recorded. Findings automatically detected by were correlated with...
The question of overtreatment ductal carcinoma in situ (DCIS) was raised because a significant proportion especially low-grade DCIS lesions never progress to invasive cancer. rationale for the present study analyze value stereotactic vacuum-assisted biopsy (VAB) complete removal DCIS, focusing on relationship between absence residual microcalcifications after VAB and histopathological diagnosis definitive surgical specimen.Data 58 consecutive patients diagnosed with by single breast center...
Abstract Background: Neoadjuvant chemotherapy (NACT) is increasingly used in patients with breast cancer. However, predicting response to NACT remains a challenge everyday clinical practice. Increasing (pre)- and evidence demonstrate the importance of cancer biomechanics mediating therapy response. We others have previously demonstrated that complex biomechanical alterations tissues, can be measured by Atomic Force Microscopy (AFM) at nanoscale level. Incorporating AFM measurements biopsies...
Phase-contrast mammography is a rising technology where, in addition to X-ray absorption, images show phase and dark-field contrast. Although the use of biopsy markers constitutes fundamental task breast examinations, there has not been any investigation concerning appropriate clips for this technology. We studied suitability three (Tumark, Somatex Medical Technologies; Hydromark, Mammotome; Mammostar, Mammotome) modality on laboratory source setup using chicken phantom. The first two...
A 52-year-old patient referred to our hospital for a screening mammogram showed suspicious new architectural distortion. Previously, fibroadenolipoma within the right breast was diagnosed clinically and radiologically. Further work-up with tomosynthesis, magnetic resonance imaging, resonance-guided biopsy an invasive ductal carcinoma fibroadenolipoma, which are usually benign lesions not associated malignancy. This case report offers review of literature discussion signs, should alert radiologist.
Bladder cancer is the fourth most common malignancy among men in Western world. Bone metastasis occurs 27 % of cases. Usually, location spine. The present report describes first case a proven distant bone to acromion from urinary bladder carcinoma patient with shoulder pain.
11618 Background: Assessment of tumor aggressiveness is crucial when making treatment decisions. Established prognostic markers may be insufficient to stratify cancer patients into relevant risk groups. Emerging evidence indicates mechanical properties cells and their microenvironment play a vital role in invasion metastases. Detecting measuring these nanomechanical changes could marker aggressiveness. Methods: We developed an atomic force microscope (AFM) based method: ARTIDIS (Automated...
BackgroundMultimodal ultrasound tomography (MUT) is a promising new three-dimensional imaging technology for breast cancer detection without ionizing radiation or need tissue compression. It offers an automatic scan of the pendulant whole breast. PurposeAs properties are affected by menstrual cycle (MC), we examined whether there objective difference in refractivity and attenuation images obtained via MUT at different phases cycle. Material MethodsThirteen asymptomatic volunteers (age range...
Abstract Mechanical properties and physical interactions of cells their microenvironment that occur at nanometre scale play a critical role in cancer progression metastatic dissemination (https://physics.cancer.gov). Nanomechanical profiling breast tissue enables fast precise diagnosis. Detecting extreme viscoelastic (soft) biopsies provides direct biomarker aggressiveness (Plodinec et. al., 2012). In an ongoing single centre clinical trial conducted routine setting we distinguish benign...
Mechanical properties and physical interactions of cells their microenvironment that occur at nanometre scale play a critical role in cancer progression metastatic dissemination (https://physics.cancer.gov). Nanomechanical profiling breast tissue enables fast precise diagnosis. Detecting extreme viscoelastic (soft) biopsies provides direct biomarker aggressiveness (Plodinec et. al., 2012). In an ongoing single centre clinical trial conducted routine setting we distinguish benign from...
Abstract Background The crucial point in making treatment decisions for breast cancer patients is the assessment of tumour aggressiveness. established prognostic markers may be insufficient to stratify into relevant risk groups. Emerging evidence indicates that mechanical properties cells and their microenvironment occur on a nanometre scale play critical role invasion metastases. Therefore, detecting these nanomechanical changes could serve as biomarker Trial design We conduct prospective,...
Hand-held speed-of-sound (SoS) ultrasound (US) is an imaging technology for breast density (BD) assessment without ionizing radiation or need compression. The purpose of the study was to investigate changes in BD during menstrual cycle and evaluate inter-breast -segment as well reproducibility method.