A5076309545- Ovarian cancer diagnosis and treatment
- Breast Cancer Treatment Studies
- Renal Transplantation Outcomes and Treatments
- Breast Lesions and Carcinomas
- Advanced X-ray Imaging Techniques
- Organ Donation and Transplantation
- Reproductive System and Pregnancy
- Cutaneous lymphoproliferative disorders research
- Cutaneous Melanoma Detection and Management
- Immune Cell Function and Interaction
- Cancer and Skin Lesions
- Urinary and Genital Oncology Studies
- Genetic factors in colorectal cancer
- Lymphoma Diagnosis and Treatment
- Renal and Vascular Pathologies
- Cancer Immunotherapy and Biomarkers
- X-ray Spectroscopy and Fluorescence Analysis
- Cancer Genomics and Diagnostics
- Endometrial and Cervical Cancer Treatments
- Advanced X-ray and CT Imaging
- Cytomegalovirus and herpesvirus research
- Bladder and Urothelial Cancer Treatments
- Immunotherapy and Immune Responses
- Endometriosis Research and Treatment
- Prostate Cancer Diagnosis and Treatment
Kantonsspital Baden
2015-2024
University Hospital of Basel
2004-2023
Spital Limmattal
2023
Kantonsspital Graubünden
2023
University Hospital of Zurich
2023
Medical University of Graz
2011-2019
Universitätsklinik für Kinder und Jugendpsychiatrie
2013-2019
Philips (Germany)
2012-2013
University of Lausanne
2012
Taipei Institute of Pathology
2012
Activating mutations in KRAS and one of its downstream mediators, BRAF, have been identified a variety human cancers. To determine the role BRAF ovarian carcinoma, we analyzed both genes for three common (at codon 599 codons 12 13 KRAS). Mutations either or occurred 15 22 (68%) invasive micropapillary serous carcinomas (MPSCs; low-grade tumors) 31 51 (61%) borderline tumors (precursor lesions to MPSCs). None contained mutation KRAS. In contrast, none 72 conventional aggressive high-grade two...
The infrequent association of serous borderline tumors (SBTs) with invasive carcinoma has led to the view that SBTs are unrelated carcinoma. Nonetheless, mortality associated is generally attributed malignant transformation, and traditionally these have been designated as "carcinomas low potential." Previous immunohistochemical studies evaluating p53 expression molecular genetic mutational status reported overexpression mutations in occur many 50% 80% carcinomas. different methodologies for...
Objectives: Phase-contrast and scattering-based x-ray imaging are known to provide additional complementary information conventional, absorption-based methods, therefore have the potential play a crucial role in medical diagnostics. We report on first mammographic investigation of 5 native, that is, freshly dissected, breasts carried out with grating interferometer conventional tube source. Four patients this study had histopathologically proven invasive breast cancer. One male patient,...
Adjuvant chemotherapy decisions in breast cancer are increasingly based on the pathologist's assessment of tumor proliferation. The Swiss Working Group Gyneco- and Breast Pathologists has surveyed inter- intraobserver consistency Ki-67-based proliferative fraction carcinomas.Five pathologists evaluated MIB-1-labeling index (LI) ten carcinomas (G1, G2, G3) by counting eyeballing. In same way, 15 all over Switzerland then assessed MIB-1-LI three G2 carcinomas, self-selected or pre-defined...
Aberrant activation of the Wnt signaling pathway plays an important role in development solid tumors such as breast and colon cancer. Secreted Frizzled-related protein 1 (SFRP1) is a negative regulator pathway. It has been described that SFRP1 mRNA strongly down-regulated cancer putative tumor suppressor function postulated. We have generated characterized specific antibody to analyze its expression on level investigate association with clinicopathological parameters patient survival....
Background: Allelic imbalance (AI), the loss or gain of chromosomal regions, is found in many cancers. AI can be detected genomic tumor DNA released into blood after necrosis apoptosis. We evaluated plasma concentration, allelic status DNA, and serum CA 125 level as screening tests for ovarian other Methods: Plasma samples were obtained from 330 women (44 normal healthy control individuals, 122 patients with various cancers, 164 non-neoplastic diseases). concentration was determined all...
HLA-G is a nonclassical MHC class I antigen that has been shown to be specific marker for normal intermediate trophoblast (IT). In this study immunoreactivity assessed with an antibody (4H84) was detected in all 14 cases of choriocarcinoma, placental site trophoblastic tumors, 13 epithelioid 16 nodules, and nine exaggerated sites. contrast, not 34 nontrophoblastic uterine neoplasms. present the IT cells sites tumors 70–100% nodules tumors. The pattern distribution different subpopulations...
The goal of this study was to examine the functional responses and tolerance susceptibility T lymphocytes from mice autoimmune strain, MRL/lpr. A population autoreactive CD4+ cells can be readily expanded lymphoid tissues young lpr mice. Lines IL-2-producing alloreactive +/+ were developed their tolerance-inducing stimuli. Culture with high concentrations immobilized anti-CD3 antibody induces both anergy apoptosis. By contrast, lpr-derived cell lines are relatively resistant implications...
Grating-interferometry-based mammography (GIM) might facilitate breast cancer detection, as several research works have demonstrated in a pre-clinical setting, since it is able to provide attenuation, differential phase contrast, and scattering images simultaneously. In order translate this technique the clinics, has be adapted cover large field-of-view within clinically acceptable exposure time radiation dose.We set up grating interferometer that fits into standard system fulfilled...
Abstract Background Endometriosis is characterized by the ectopic occurrence of endometrial tissue. Though considered benign, endometriotic lesions possess tumor-like properties such as tissue invasion and remodeling extracellular matrix. One major clinical hurdle concerning endometriosis its diagnosis. The diagnostic modalities ultrasound MRI are often unable to detect all lesions, a clear correlation between imaging symptoms still controversial. Therefore, it was our aim identify potential...
We previously proposed a dualistic model for ovarian serous carcinogenesis. One pathway involves the stepwise development of invasive micropapillary carcinoma (MPSC) from borderline tumor (atypical proliferative tumor) to noninvasive and then MPSC. The carcinomas that develop in this fashion are characterized by low-grade nuclei frequent K-ras mutations. They generally pursue an indolent course. In other conventional (CSC) develops de novo surface epithelium without what appears be...
Objectives Differential phase contrast and scattering-based x-ray mammography has the potential to provide additional complementary clinically relevant information compared with absorption-based mammography. The purpose of our study was a first statistical evaluation imaging capabilities new technique digital absorption Materials Methods We investigated non-fixed mastectomy samples 33 patients invasive breast cancer, using grating-based differential (mammoDPC) conventional, low-brilliance...
Non-mass enhancement (NME) in breast MRI is the most common feature of ductal carcinoma situ (DCIS). We sought to evaluate interobserver variability and positive predictive value (PPV) for malignancy NME descriptors using fifth edition BI-RADS lexicon focusing on newly introduced "clustered ring enhancement" pattern.Breast MRIs 129 patients who had undergone MRI-guided vacuum-assisted biopsy (VAB) our institution were reviewed. Studies assessed as classified according by two radiologists....
Previously published studies concerning autopsy findings in ovarian cancer failed to consider the broad differences factors that influence course of disease. Furthermore, those were conducted when currently accepted standards diagnostics and therapy had not been fully established. The objective current study was determine frequency sites metastases patients with particular attention clinical therapy.Autopsy reports, histologic slides, files from 197 who died carcinoma between 1975 2005...
Success of epidermal growth factor receptor (EGFR) targeting agents in different cancer types is related to EGFR gene mutations and/or copy number gains. We investigated the status and protein expression by DNA mutational analysis, fluorescence situ hybridization (FISH), immunohistochemistry tumor tissues from 80 patients with primary corresponding recurrent ovarian serous carcinomas. The were classified into six groups ascending numbers. amplification high polysomy (FISH+) was present a...
The identification of glypican-3 (GPC3) expression in malignant neoplasms is potentially interest because GPC3 might represent a therapeutic target. Tissue microarrays containing tissue cylinders from 308 patients with ovarian carcinomas were used for an immunohistochemical study. There 255 serous, 38 endometrioid, and 15 clear-cell included. From 76 patients, paired samples primary serous their corresponding recurrences after platinum-based chemotherapy available. Glypican-3 was expressed...
Abstract Microsatellite instability at mono‐ and dinucleotide repeats is the hallmark of hereditary non‐polyposis cancer syndrome (HNPCC) related to deficient DNA mismatch repair. In contrast, a distinct form microsatellite selective tetranucleotide (EMAST or elevated alterations selected tetranucleotides) was described in several non‐HNPCC types. EMAST probably unrelated repair defects. We investigated frequency mononucleotide, series 75 ovarian carcinomas (53 serous 22 non‐serous)....
Our aim was to investigate the prognostic and predictive value of oncogenic MAPKK-like protein T-cell-originated kinase (TOPK) stratified by KRAS BRAF mutations in patients with sporadic, hereditary metastatic colorectal cancer (CRC) treated anti-EGFR therapy.Immunohistochemistry (IHC) for TOPK performed on four study groups. Group 1 included two subgroups 543 501 sporadic CRC used test reliability expression IHC. In 2, representing an additional 222 CRCs, effect assessed. The further...
Endocrine therapy is used as maintenance in estrogen receptor (ER) positive breast cancers and has been proposed low-grade serous ovarian (LGSOC). Here we examine a rationale for its use high-grade (HGSOC).We accessed the TCGA PANCAN dataset to evaluate expression of ESR1. ESR1 data on all (n=8901) HGSOC (n=527) were followed by investigation ER via immunohistochemistry (IHC) (n=4071). The same was performed an independent cohort matched primary recurrent (n=80). Finally, newly diagnosed ER+...