A5060366124- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- Cancer Treatment and Pharmacology
- Cancer Risks and Factors
- Advanced Breast Cancer Therapies
- Medical Imaging Techniques and Applications
- HER2/EGFR in Cancer Research
- Ultrasound Imaging and Elastography
- Ultrasound and Hyperthermia Applications
- Cancer and Skin Lesions
- Radiomics and Machine Learning in Medical Imaging
- Biosimilars and Bioanalytical Methods
- Nonmelanoma Skin Cancer Studies
- Advances in Oncology and Radiotherapy
- Reproductive Biology and Fertility
- Public Administration and Political Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Estrogen and related hormone effects
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- AI in cancer detection
University of Rostock
2016-2025
Klinikum Südstadt Rostock
2014-2025
Neu Ulm University of Applied Sciences
2022
Universitätsmedizin Rostock
2021-2022
Universitäts Frauenklinik
2016-2020
LMU Klinikum
2010
Ludwig-Maximilians-Universität München
2010
München Klinik
2010
Axillary lymph node status remains an important prognostic factor in early breast cancer. It is regarded as indicator for (neo)adjuvant systemic treatment and postoperative radiotherapy of the regional lymphatics. Commenced September 2015, INSEMA trial investigating whether operative determination nodal part conserving therapy (BCT) stage cancer (c/iT1-2 c/iN0) can be avoided without reducing oncological safety. After inclusion 1001 patients there was general acceptance complex study design...
Clipping and selective removal of initially suspicious axillary lymph nodes in breast cancer patients who have been sonographically down-staged by primary systemic therapy improves the accuracy surgical staging provides opportunity for more conservative surgery. This study evaluated whether preoperative ultrasound-guided wire localization clipped node is useful routine clinical practice.This prospective, single-center feasibility trial included with invasive (cT1-3N1-3M0) treated therapy....
Abstract Neoadjuvant chemotherapy (NACT) is frequently used in patients with early breast cancer. Randomized controlled trials have demonstrated similar survival after NACT or adjuvant (ACT). However, certain subtypes may benefit more when contains regimes leading to high rates of pathologic complete response (pCR) rates. In this study we analyzed data using the OncoBox research from 94,638 treated 55 cancer centers describe current clinical practice and outcomes under routine conditions....
<b>Purpose:</b> We compared strain ratio vs. qualitative elastography for the further differentiation of focal breast lesions, with special focus on limiting factors. <b>Materials and Methods:</b> 215 patients 224 histologically proven masses (116 malignant, 108 benign) were prospectively examined using a high-end ultrasound system (Philips iU22) serial function. B-mode scans available mammograms reviewed according to BIRADS classification, raw elastogram data was analyzed qualitatively...
Since the performance of surgical procedures axilla in treatment early breast cancer is decreasing, role axillary ultrasound (AUS) as staging procedere has newly to be addressed. The aim this study was determine which patient or histopathological characteristics are related false-negative AUS. In a retrospective design data 470 women with primary were collected from charts and imaging pathology records reviewed. True positive false negative groups compared terms tumor size, histological...
Abstract Background Several techniques for targeted lymph node biopsy in patients with node-positive breast cancer receiving primary systemic therapy are use, each their inherent advantages and disadvantages. The aim of the TATTOO trial was to evaluate feasibility accuracy carbon tattooing positive nodes as a method avoiding radiation exposure, high costs, preoperative localization procedures. Methods Patients initially cT1–4c cN1–3 cM0 invasive were included this prospective multicentre...
In clinically node-positive breast cancer patients receiving neoadjuvant systemic therapy (NST), nodal metastases can be initially marked and then removed during surgical axillary staging. Marking methods vary significantly in terms of feasibility cost. The purpose the extended TATTOO trial was to report on false-negative rate (FNR) low-cost method carbon tattooing.
Das axilläre Staging bildet einen integralen Bestandteil in der chirurgischen Behandlung des frühen Mammakarzinoms. Hier stellt bei Patientinnen mit initial klinisch und sonographisch unauffälligen Lymphknoten (cN0) die Sentinel-Lymphonodektomie (SLNE) sowohl primär geplanter Operation als auch nach Neoadjuvanz den Goldstandard dar. Nach Publikation ACOSOG-Z011-Studie wird cN0-Patientinnen primärer brusterhaltender Therapie Bestrahlung postoperativ bis zu 2 befallenen Sentinel-Lymphknoten...
Abstract Purpose Currently, various techniques are available to mark and selectively remove initially suspicious axillary lymph nodes (target nodes, TLNs) in breast cancer patients receiving neoadjuvant chemotherapy (NACT). To date, limited data on whether the use of magnetic seeds (MS) is suitable for localizing TLNs. This study aimed investigate feasibility MS undergoing target node biopsy (TLNB) or targeted dissection (TAD) after NACT. Methods Prospective from ongoing multicentric AXSANA...
<b>Purpose:</b> To evaluate the accuracy of axillary ultrasound (AUS) in detecting nodal metastasis patients with early-stage breast cancer and to identify AUS features high predictive power. <b>Materials Methods:</b> Prospective single-center preliminary study 105 a primary diagnosis clinically negative axilla. was performed using 12 MHz linear-array transducer before ultrasound-guided needle biopsy. Nodal characteristics (shape, longitudinal-transverse [LT] axis ratio, margins, cortical...
Introduction To date, the optimal axillary staging procedure for initially node-positive breast carcinoma patients after neoadjuvant chemotherapy (NACT) has been unclear. The aim of AXSANA study is to prospectively compare different surgical techniques with respect oncological outcome and quality life patients. Little known about current clinical practice in Germany. Material Methods In this paper we analyzed data from enrolled at German sites June 2020 March 2022. Results During period...
Background: The aim of this article was to evaluate the prognostic value MammaPrintTM signature in women ≧ 60 years with invasive breast cancer. Patients and Methods: female patients were included prospective study. Eligibility criteria included: pT1c-3, pN0-1a, grade 2/3, hormone receptor-positive HER2-negative tumor. clinical risk determined by Adjuvant! Online (AOL). Results: 38 (63%) where considered be low-risk 70-gene signature, while 22 (37%) high-risk patients. No statistically...
Because inheritance is recognized as playing a role in age at menarche and natural menopause, the development of chemotherapy-induced amenorrhea (CIA) might depend on inherited genetic factors; however, studies that explore such correlation are few have received scant attention. Given importance this topic we conducted comprehensive genotype study young women (≤45 years) with early-stage breast cancer.Our approach tested effect variant polymorphisms drug metabolism enzymes (DMEs) using...
Purpose: In preparation of a planned study to compare axillary sentinel lymph node biopsy (SLNB) versus no surgery in patients with early breast cancer (Intergroup-Sentinel-Mamma-Trial) we evaluated the accuracy ultrasound (AUS) detecting nodal metastasis. The aim was identify features high predictive power and create suitable clinical flow chart.