A5073307551- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- BRCA gene mutations in cancer
- Cancer Risks and Factors
- Social and Educational Sciences
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
Karolinska Institutet
2014-2023
Saint Göran Hospital
2020
Stockholm South General Hospital
2014-2017
Patients with clinically node-positive breast cancer planned for neoadjuvant systemic therapy (NAST) may draw advantages from the nodal downstaging effect and reduce extent of axillary surgery sentinel lymph node biopsy (SLNB) performed after NAST. Since there are concerns about lower (SLN) detection higher false-negative rates (FNR) in this setting, our aim was to define accuracy SLNB This Swedish national multicenter trial prospectively recruited 195 patients ten hospitals T1–T4d...
Abstract Purpose Currently, various techniques are available to mark and selectively remove initially suspicious axillary lymph nodes (target nodes, TLNs) in breast cancer patients receiving neoadjuvant chemotherapy (NACT). To date, limited data on whether the use of magnetic seeds (MS) is suitable for localizing TLNs. This study aimed investigate feasibility MS undergoing target node biopsy (TLNB) or targeted dissection (TAD) after NACT. Methods Prospective from ongoing multicentric AXSANA...
Abstract Background Positive sentinel lymph nodes (SLNs) are found in up to 13 per cent of women with a preoperative diagnosis ductal carcinoma situ (DCIS) the breast and 4 those postoperative diagnosis. This retrospective national register study investigated incidence positive SLNs DCIS, value additional tumour sectioning identify occult invasion. Methods All surgical patients final histopathological pure DCIS registered Swedish cancer 2008 2009 were eligible. Additional was performed on...
Abstract Background This follow-up analysis of a Swedish prospective multicentre trial had the primary aim to determine invasive disease-free (IDFS), breast cancer-specific (BCSS) and overall survival (OS) rates, their association with axillary staging results before after neoadjuvant systemic therapy for cancer. Methods Women who underwent clinically node-positive (cN+) or -negative (cN0) cancer between 2010 2015 were included. Patients sentinel lymph node biopsy and/or therapy, all...
Abstract Purpose The timing of sentinel lymph node biopsy (SLNB) in the context neoadjuvant systemic therapy (NAST) breast cancer is still controversial. SLNB before NAST has been evaluated few single-institution studies which axillary dissection (ALND), however, was commonly not performed case a negative SLNB. We investigated potential clinical relevance by performing ALND all patients after NAST. Methods This national multicenter trial prospectively enrolled clinically node-negative...