A5012257101- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Breast Lesions and Carcinomas
- Atrial Fibrillation Management and Outcomes
- Glaucoma and retinal disorders
- Reconstructive Surgery and Microvascular Techniques
- Folate and B Vitamins Research
- Cancer Diagnosis and Treatment
- Medical and Biological Sciences
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Blood Pressure and Hypertension Studies
- Statistical Methods in Clinical Trials
- Meta-analysis and systematic reviews
- Dental Implant Techniques and Outcomes
- Statistical Methods and Inference
- Pregnancy and preeclampsia studies
- Pharmacological Effects and Toxicity Studies
- Temporomandibular Joint Disorders
- Medical Imaging Techniques and Applications
- Kidney Stones and Urolithiasis Treatments
- Parathyroid Disorders and Treatments
- Orthodontics and Dentofacial Orthopedics
- Cardiovascular Health and Disease Prevention
- Cerebral Palsy and Movement Disorders
University of Rostock
2014-2024
Universitätsmedizin Rostock
1984-2020
German Breast group
2016
University Medical Center
2014
Zimmer Biomet (Germany)
2004-2012
Institute for Medical Informatics and Biostatistics
2010
Rostocker Zentrum zur Erforschung des Demografischen Wandels
2009
University of Duisburg-Essen
2009
University of Vienna
2009
Leipzig Heart Institute
2009
We assessed the prognostic significance of presence micrometastasis in bone marrow at time diagnosis breast cancer by means a pooled analysis.
Thoracic endovascular aortic repair (TEVAR) represents a novel concept for type B dissection. Although life-saving in acute emergencies, outcomes and survival of TEVAR stable dissection are unknown.One hundred forty patients clinical condition at least 2 weeks after index were randomly subjected to elective stent-graft placement addition optimal medical therapy (n=72) or alone (n=68) with surveillance (arterial pressure according World Health Organization guidelines < =120/80 mm Hg). The...
In Brief Objective: To find out if skin sparing mastectomy (SSM) and nipple (NSM) with immediate autologous reconstruction as safe in oncological terms modified radical (MRM). Summary Background: The safety of less surgical procedures like SSM NSM cannot be evaluated by randomized trials. A careful long lasting follow-up patients, treated or NSM, is urgently needed. Patients Methods: Between 1994–2000, 246 selected patients an indication for MRM were SSM, MRM. Short term results published...
Is skin-sparing mastectomy (SSM) with conservation of the Nipple-Areola Complex (NAC) and immediate autologous reconstruction as safe in oncologic terms SSM resection NAC modified radical (MRM)?The originally described technique included removal gland, NAC, biopsy scar. However, risk tumor involvement patients breast cancer has been overestimated.Between 1994 2000, 286 selected an indication for MRM margins greater than 2 cm from nipple were presented alternative a SSM. Regular follow-up...
OBJECTIVES. Childhood obesity contributes to the development of adult and subsequent cardiovascular disease. The present study aimed assess vascular status (flow-mediated vasodilation [FMD], intima-media thickness [IMT]) analyze plasma surrogate endothelial markers (von Willebrand factor [vWf], E-selectin, thrombomodulin) in obese children as compared with controls. Associations between early morphologic functional changes, soluble atherosclerosis, risk profile were determined. METHODS. We...
The standard estimator for the log odds ratio (the unconditional maximum likelihood estimator) and delta‐method its error are not defined if corresponding 2 × table contains at least one “zero cell”. This is also an issue when estimating overall in a meta‐analysis. It well known that correcting zero cells by adding small increment should be avoided. Nevertheless, these zero‐cell corrections continue to used. With this Brief Method Note, we want warn of particularly bad correction. For this,...
PURPOSE: We studied the prognostic and predictive value of immunohistochemically detected occult tumor cells (OTCs) in lymph nodes bone marrow aspirates obtained from node-negative breast cancer patients. All were classified as distant metastases-free using conventional staging methods. PATIENTS AND METHODS: A total 484 patients with pT1-2N0M0 70 pT1-2N1M0 a single affected node participated our trial. Ipsilateral axillary intraoperatively aspirated examined. samples examined for OTCs...
The phase III clinical trial PERFECT was designed to assess safety and efficacy of intramyocardial CD133+ bone marrow stem cell treatment combined with CABG for induction cardiac repair.Multicentre, double-blinded, randomised placebo controlled trial.The study conducted across six centres in Germany October 2009 through March 2016 stopped due slow recruitment after positive interim analysis 2015.Post-infarction patients chronic ischemia reduced LVEF (25-50%).Eighty-two were two groups...
After neoadjuvant radiochemotherapy and surgery, there is no general agreement about whether postoperative chemotherapy necessary. With the help of clinical pathohistologic data, prognostic factors were determined as a basis for decision to spare patient additional or urgently recommend it.Ninety-five patients treated with 5-fluorouracil-based (November 4, 1997 June 15, 2004) without distant metastases an R0 (microscopically complete) resection evaluated. Adjuvant (5-fluorouracil...
<b>Purpose:</b> We compared strain ratio vs. qualitative elastography for the further differentiation of focal breast lesions, with special focus on limiting factors. <b>Materials and Methods:</b> 215 patients 224 histologically proven masses (116 malignant, 108 benign) were prospectively examined using a high-end ultrasound system (Philips iU22) serial function. B-mode scans available mammograms reviewed according to BIRADS classification, raw elastogram data was analyzed qualitatively...
Increased cardiovascular morbidity is manifested a long time after the repair of aortic coarctation (CoA). By way impaired flow-mediated vasodilation (FMD) and increased intima media thickness (IMT), surrogate parameters atherosclerosis, risk factors (RFs) can be correlated with early vascular wall changes in children. This study investigated whether arterial function morphology are detectable children repair.We examined 28 successful CoA vs. 30 control subjects. All underwent identical...
Transcatheter aortic valve implantation (TAVI) has been established as a treatment option for inoperable patients with symptomatic stenosis. However, suffer frequently from conduction disturbances after TAVI.Baseline, procedural well surface and intracardiac ECG parameters were evaluated treated TAVI comparison between requiring pacemaker those not suffering relevant disorders done.TAVI was successfully in all (n=45). Baseline recording revealed longer PQ (197.1±51.2 msec versus 154.1±32.1...
[Purpose] The purpose of this single-center investigation was to study the impact pregnancy on back pain and body posture. [Subjects] subjects were 26 pregnant females. [Methods] Data generated with a spine scanner (Diers(®) formetric 4D), trunk strength measurement myoline), numeric scale (0 10), biomechanical model. Parameters compared during each trimester. [Results] alteration in level at rest lumbar lordosis angle females revealed statistical trend pregnancy. Spearman's test showed...
The volatile transmitter hydrogen sulfide (H2S) is known for its various functions in vascular biology. This study evaluates the effect of H2S-donor GYY4137 (GYY) on thrombus stability and microvascular thrombolysis. Human whole blood served all vitro studies was analyzed a resting state, after stimulation with thrombin-receptor activating peptide (TRAP) incubation 10 or 30 mM GYY vehicle DMSO following TRAP-activation, respectively. As marker stability, platelet-leukocyte aggregation...
Objectives: Pancreatic stellate cells (PSCs) are known to be crucially involved in the development of pancreatic fibrosis, a characteristic feature chronic pancreatitis and cancer. The key event pathogenesis fibrosis represents transition process quiescent PSCs into myofibroblastlike phenotype associated with cell activation terms proliferation synthesis profibrogenic substances. There is little information available regarding dynamics complex processes initiated by an activating stimulus...