A5088431173- Nerve injury and regeneration
- COVID-19 and healthcare impacts
- Spinal Cord Injury Research
- Bariatric Surgery and Outcomes
- Breast Cancer Treatment Studies
- Neurogenesis and neuroplasticity mechanisms
- Global Cancer Incidence and Screening
- Tendon Structure and Treatment
- Esophageal and GI Pathology
- Renal and Vascular Pathologies
- Diet and metabolism studies
- Gastric Cancer Management and Outcomes
- Transcranial Magnetic Stimulation Studies
- Trauma and Emergency Care Studies
- Signaling Pathways in Disease
- Myasthenia Gravis and Thymoma
- Parkinson's Disease Mechanisms and Treatments
- Head and Neck Anomalies
- Appendicitis Diagnosis and Management
- Nerve Injury and Rehabilitation
- Hip and Femur Fractures
- Breast Lesions and Carcinomas
- Abdominal Surgery and Complications
- Neurogenetic and Muscular Disorders Research
- Cardiac, Anesthesia and Surgical Outcomes
University College London Hospitals NHS Foundation Trust
2025
University College London
2022-2025
Whittington Health NHS Trust
2024
Whittington Hospital
2022-2023
North Middlesex Hospital
2021
Middlesex University
2021
John Wiley & Sons (United States)
2019
St Thomas' Hospital
2019
Hudson Institute
2019
King's College London
2011-2018
Chondroitin sulfate proteoglycans (CSPGs) inhibit repair following spinal cord injury. Here we use mammalian-compatible engineered chondroitinase ABC (ChABC) delivered via lentiviral vector (LV-ChABC) to explore the consequences of large-scale CSPG digestion for repair. We demonstrate significantly reduced secondary injury pathology in adult rats contusion and LV-ChABC treatment, with cavitation enhanced preservation neurons axons at 12 weeks postinjury, compared control (LV-GFP)-treated...
In amyotrophic lateral sclerosis (ALS), the progressive loss of motor neurons is accompanied by extensive muscle denervation, resulting in paralysis and ultimately death. Upregulation amyloid beta (A4) precursor protein (APP) fibres coincides with symptom onset both sporadic ALS patients SOD1G93A mouse model familial ALS. We have further characterized this response mice also revealed elevated levels β-amyloid (Aβ) peptides spinal cord, which were predominantly localized within their...
<title>Abstract</title> Background Ectopic aberrant thymic tissue is most commonly found in the thyroid gland and increasingly incidentally due to widespread use of ultrasound. Correct identification this benign pathology on ultrasound can avoid morbidity associated with fine needle aspiration (FNA) anxiety a possible cancer diagnosis. Methods A case series 21 children have likely intrathyroidal scan neck between 2013 2024 at University College London Hospital. Results aged six months ten...
18-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) is valuable in the management of patients with oesophageal cancer, but a role gastric cancer staging debated. Our aim was to review FDG PET-CT large cohort tertiary UK centre.
Objective Neurotrophin‐3 (NT3) plays a key role in the development and function of locomotor circuits including descending serotonergic corticospinal tract axons afferents from muscle skin. We have previously shown that gene therapy delivery human NT3 into affected forelimb muscles improves sensorimotor recovery after stroke adult elderly rats. Here, to move toward clinic, we tested hypothesis intramuscular infusion protein could improve stroke. Methods Rats received unilateral ischemic...
Abstract Stroke often leads to arm disability and reduced responsiveness stimuli on the other side of body. Neurotrophin-3 (NT3) is made by skeletal muscle during infancy but levels drop postnatally into adulthood. It essential for survival wiring-up sensory afferents from muscle. We have previously shown that gene therapy delivery human NT3 affected triceps brachii forelimb improves sensorimotor recovery after ischemic stroke in adult elderly rats. Here, move this one step nearer clinic, we...