Hans Lederhuber
A5017101729- COVID-19 and healthcare impacts
- Cardiac, Anesthesia and Surgical Outcomes
- Hernia repair and management
- Trauma and Emergency Care Studies
- Hip and Femur Fractures
- Heat shock proteins research
- Stoma care and complications
- Diversity and Career in Medicine
- Colorectal Cancer Surgical Treatments
- Muscle metabolism and nutrition
- Healthcare professionals’ stress and burnout
- Ultrasound in Clinical Applications
- Iron Metabolism and Disorders
- Global Cancer Incidence and Screening
- Global Health and Surgery
- Respiratory Support and Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Healthcare cost, quality, practices
- Radiation Dose and Imaging
- Pelvic and Acetabular Injuries
- Dialysis and Renal Disease Management
- Body Contouring and Surgery
- Cardiovascular Disease and Adiposity
- Blood transfusion and management
- Climate Change and Health Impacts
Royal Devon & Exeter NHS Foundation Trust
2021-2024
National Institute for Health Research
2024
University of Birmingham
2024
University of Liverpool
2021
Society of Surgical Oncology
2021
Hospital Italiano de Buenos Aires
2021
Royal Brisbane and Women's Hospital
2021
County Administrative Board
2019
Medical University of Vienna
2009-2016
Center for Inherited Blood Disorders
2010
The 2015 Lancet Commission on global surgery identified and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility planned surgical services around world, which have also been neglected in pandemic recovery planning. This study aimed to develop validate a novel index support local elective system strengthening address growing backlogs.
Pulmonary complications are the most common cause of death after surgery. This study aimed to derive and externally validate a novel prognostic model that can be used before elective surgery estimate risk postoperative pulmonary support resource allocation prioritisation during pandemic recovery. Data from an international, prospective cohort were develop for in adult patients (aged ≥18 years) across all operation disease types. The primary outcome measure was at 30 days surgery, which...
from 3 countries (China (1), Netherlands and the UK (3)), including a total of 485 patients (Table 1).Four trials specified source funding one 25 provided ambiguous
Concise regulation of the Toll signaling pathway is mandatory in neonatal innate immunity. The microRNA-146 family (miR-146a/b) was recently reported to be a regulator Toll-like receptor 4 (TLR4) through negative feedback loop mechanism. Acting as potent regulator, miRNA helps protect organism from developing overwhelming proinflammatory immune responses leading septic shock or chronic inflammatory diseases.We investigated for first time whether miRNA-146a/b plays regulatory role human...
During the initial COVID-19 outbreak up to 28.4 million elective operations were cancelled worldwide, in part owing concerns that it would be unsustainable maintain surgery capacity because of COVID-19-related surgeon absence. Although many hospitals are now recovering, surgical teams need strategies prepare for future outbreaks. This study aimed develop a framework predict during An international cross-sectional determined real-world absence rates among surgeons. absences included sickness,...
Renal replacement therapy by peritoneal dialysis is frequently complicated technical failure. Peritoneal fluids (PDF) cause injury to the mesothelial cell layer due their cytotoxicity. As only isolated elements of involved cellular processes have been studied before, we aimed at a global assessment stress response PDF. Following single or repeated exposure PDF control medium, proteomics and bioinformatics techniques were combined study effects in cells (MeT-5A). Protein expression was...
Low biocompatibility of peritoneal dialysis solution (PDS) injures mesothelial cells but also induces heat shock proteins (HSP), the main effectors cellular stress response. This study investigated whether overexpression HSP upon pharmacologic induction results in cytoprotection experimental PD.Stress response exposure to PDS was pharmacologically manipulated using glutamine as a co-inducer. In vitro, HSP-mediated assessed by simultaneous measurements expression Western blot analysis and...
Abstract Aim Parastomal hernia repair is a poorly evidenced area, with uncertainty around the optimum management. There considerable heterogeneity within patient cohort, and currently there no standardization of descriptors in reporting parastomal repair. The aim this study was to develop core descriptor set key characteristics for patients undergoing surgical all research. Method A longlist generated from review existing literature. discussed lived experience Colorectal, general surgeons...
The aim of this study was to investigate whether differences in postoperative outcome exist between open inguinal hernia repairs performed by surgical trainees and those specialist surgeons.Inguinal repair is the prototype educational procedure. impact trainee participation on still controversial despite earlier studies no reliable hernia-specific data exist.The cohort based Swedish Hernia Register consisted 61,161 cases male patients aged 18 years older with anterior mesh a primary January...
Implantation of a gastric stimulator is feasible surgical therapy for patients with refractory gastroparesis. In addition it seems to be promising alternative treating morbid obesity. We present the first time emergency small bowel obstruction due strangulation by electrodes. A 59-year-old Caucasian female had undergone implantation cope symptoms partial Eight years after operation, patient began repeatedly different hospitals because abdominal pain and nausea. Symptoms imaging indicated...
Abstract Aim The evidence base for statements about risk factors, morbidity and mortality emergency hernia repair is mostly low quality. aim of this study to elucidate factors the development incarcerated outcome after adult using data from Swedish Hernia Register (SHR). Material Methods Data in observational were extracted SHR. It included registered cases between January 1, 2009 December 31, 2019. Maximal follow-up was until 2020. Demographic analysed descriptively, analyses performed...