A5002039597- Management of metastatic bone disease
- Sarcoma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Spine and Intervertebral Disc Pathology
- Cardiac tumors and thrombi
- Spinal Fractures and Fixation Techniques
- Glioma Diagnosis and Treatment
- Bone health and treatments
- Breast Cancer Treatment Studies
- Advanced Radiotherapy Techniques
- Brain Metastases and Treatment
- Bone health and osteoporosis research
- Cutaneous Melanoma Detection and Management
- Radiomics and Machine Learning in Medical Imaging
- Acute Myeloid Leukemia Research
- Prostate Cancer Treatment and Research
- Phytochemistry Medicinal Plant Applications
- Advanced Biosensing Techniques and Applications
- CNS Lymphoma Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Herbal Medicine Research Studies
- Oral health in cancer treatment
- Renal cell carcinoma treatment
Queen Elizabeth Hospital Birmingham
2011-2024
University Hospitals Birmingham NHS Foundation Trust
2020-2023
Queen Elizabeth Hospital
2023
University College London
2020-2022
Royal National Orthopaedic Hospital
2022
University Hospital Coventry
2022
Edwards (United Kingdom)
2010-2021
NIHR Surgical Reconstruction and Microbiology Research Centre
2019-2020
University College Hospital
2020
Curtin University
2012
Objective: Different methods for contouring target volumes are currently in use the UK when irradiating glioblastomas post operatively. Both one- and two-phase techniques offered at different centres. 90% of relapses recognised to occur locally using radiotherapy alone. The objective this evaluation was determine pattern relapse following concomitant with temozolomide (RT-TMZ). Methods: A retrospective analysis patients receiving RT-TMZ between 2006 2010 performed. Outcome data including...
The optimal treatment for advanced leiomyosarcoma is still debated. Given histotype-specific prospective controlled data lacking, this study retrospectively evaluated doxorubicin plus dacarbazine, ifosfamide, and alone as first-line treatments advanced/metastatic treated at European Organization Research Treatment of Cancer Soft Tissue Bone Sarcoma Group (EORTC-STBSG) sites.The inclusion criteria were a confirmed histological diagnosis, between January 2010 December 2015, measurable disease...
A large proportion of cancer patients are estimated to use herbal medicines, but data substantiate this lacking. This study aimed investigate the prevalence medicine among in West Midlands, and determine characteristics predicting use.A cross-sectional survey oncology (n=1498) being followed up at a hospital Coventry was undertaken. Recipients were asked about since their diagnosis, association between sociodemographic cancer-related evaluated.A total 1134 responses received (75.7%). The...
Abstract Background Breast angiosarcomas are rare tumours of vascular origin. Secondary angiosarcoma occurs following radiotherapy for breast cancer. Angiosarcomas have high recurrence and poor survival rates. This is concerning owing to the increasing use adjuvant treatment invasive cancer ductal in situ (DCIS), which could explain rising incidence angiosarcoma. Outcome data limited provide a evidence base treatment. paper presents national, trainee-led, retrospective, multicentre study...
Positron emission tomography with CT (PET/CT) scanning is increasingly being used in head and neck cancer to assess response after radical concomitant chemoradiotherapy. The purpose of this study was the use PET/CT following chemoradiotherapy at our institution.All patients receiving for over a 9-year period were retrospectively identified. Outcome data including local control overall survival collected all patients. negative predictive value recurrence calculated. Of those reported positive...
Summary This study was conducted to establish clinicians’ perspectives of a set radiology curriculum topics for medical student teaching, which were held be important by radiologists. A questionnaire sent clinicians in all specialties. Forty‐six (51.1%) out 90 returned the questionnaires. All scored above an average 4 (agree). The five highest ranking order importance were: developing system viewing chest radiographs (5.59), abdominal (5.56), bone and joint (5.33), distinguishing normal...
Background: Sarcomas are rare and heterogeneous tumours with a large proportion of patients requiring palliative intervention. They regarded as relatively radioresistant therefore achieving good palliation radiation may require larger doses than for more common solid tumour types. Limited data is available regarding appropriate radiotherapy dose fractionation. This case series aims to assess the effectiveness in providing symptomatic improvement advanced sarcomas. Method: Data was...
There has been little change to the standard treatment for osteosarcoma (OS) over last 25 years and there is an unmet need identify new biomarkers novel therapeutic approaches if outcomes are improve. Furthermore, limited evidence on impact of OS patient-reported (PROs). ICONIC (Improving Outcomes through Collaboration in Osteosarcoma; NCT04132895) a prospective observational cohort study recruiting newly diagnosed patients across United Kingdom (UK) with matched longitudinal collection...
Radiotherapy is an effective treatment for head and neck cancers but patients often experience side effects which lead to weight loss. Nutrition intervention in the form of counselling or oral nutrition support (ONS) frequently needed these patients. For some patients, tube feeding required minimise loss during treatment.Data was collected on 48 who received radiotherapy region over a nine-month period (June 2009-March 2010). Retrospective data collection commenced July 2010. Each patient's...
Peripheral neuropathy is a well-recognised side effect of the cholesterol-lowering statins. Red yeast rice (RYR) traditional Chinese herb, widely available over-the-counter that has also been found to reduce cholesterol. Little data regarding its profile. We report case 60-year-old male receiving therapeutic imatinib for metastatic gastrointestinal tumour (GIST), who developed peripheral while taking RYR. The symptoms completely settled following withdrawal RYR and he subsequently continued...
The management of spinal metastases focuses on reducing symptoms and protecting the cord, historically involving extracorporeal radiotherapy alone. use separation surgery techniques alongside high-dose to treat is a novel concept has changed treatment paradigm. Additionally, titanium implants have been increasingly used in cases metastatic tumours requiring adjuvant stereotactic (SBRT). We present case 48-year-old female patient who was diagnosed with deposit breast cancer within L1 an...
SummaryA double-blind randomised parallel group study was carried out in 46 patients to compare the effectiveness of clemastine with that chlorpheniramine maleate treatment hay fever. The results showed both drugs were equally effective controlling symptoms fever without side-effects or other untoward reactions. It is suggested a logical first choice antihistamine as well being an alternative where tolerance antihistamines develops.
Abstract Background: During the SARS-CoV-2 virus pandemic, University Hospital Birmingham NHS Trust Oncology Department incorporated ultrahypofractionated regime of 26Gy/5 fractions alongside moderate hypofractionated 40Gy/15 as part local adjuvant breast radiotherapy treatment (RT) for eligible patients. We conducted a study to assess real-life experience patients undergoing schedule compare feasibility and toxicity fast-forward trial during COVID − 19 pandemic. Methods: A single...
Abstract Aim: Stereotactic ablative body radiotherapy (SABR) for spine metastases is associated with a risk of vertebral compression fracture (VCF). The aim this study was to determine the rate VCF at one UK institution and evaluate use Spinal Instability Neoplastic Score (SINS) predict these. Materials methods: A retrospective analysis all patients who underwent SABR spinal between 2014 2018 performed. Basic demographic data were collected, SINS prior calculated. primary outcome rate....