A5020214043- Orthopedic Surgery and Rehabilitation
- Bone fractures and treatments
- Reconstructive Surgery and Microvascular Techniques
- Hip and Femur Fractures
- Surgical site infection prevention
- Musculoskeletal synovial abnormalities and treatments
- Nonmelanoma Skin Cancer Studies
- Breast Implant and Reconstruction
- Dupuytren's Contracture and Treatments
- Medical Malpractice and Liability Issues
- Nerve Injury and Rehabilitation
- Peripheral Nerve Disorders
- Diversity and Career in Medicine
- Trauma and Emergency Care Studies
- Clinical practice guidelines implementation
- Nail Diseases and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Dental Education, Practice, Research
- LGBTQ Health, Identity, and Policy
- Breast Cancer Treatment Studies
- Rheumatoid Arthritis Research and Therapies
- Surgical Sutures and Adhesives
- Health and Medical Research Impacts
- Vascular Tumors and Angiosarcomas
- Cardiac, Anesthesia and Surgical Outcomes
Nuffield Orthopaedic Centre
2016-2025
University of Oxford
2016-2025
Imperial College Healthcare NHS Trust
2015-2024
Amity University
2024
Imperial College London
2010-2023
St Mary's Hospital
2017-2023
St Mary's Hospital
2008-2022
St. Mary's Hospital
2008-2022
Tata Motors (India)
2021
Center For Reconstructive Urethral Surgery
2020
BackgroundUse of biological or synthetic mesh might improve outcomes immediate implant-based breast reconstruction—breast reconstruction with implants expanders at the time mastectomy—but there is a lack high-quality evidence to support safety effectiveness technique. We aimed establish short-term performed and without mesh, inform feasibility undertaking future randomised clinical trial comparing different techniques.MethodsIn this prospective, multicentre cohort study, we consecutively...
Abstract Objective A hallmark of rheumatoid arthritis (RA) is invasion the synovial pannus into cartilage, and this process requires degradation collagen matrix. The aim study was to explore role one collagen‐degrading matrix metalloproteinases (MMPs), membrane type 1 MMP (MT1‐MMP), in invasiveness. Methods expression localization MT1‐MMP human RA were investigated by Western blot analysis primary cells immunohistochemical joint specimens. functional analyzed 3‐dimensional (3‐D) assays a...
The management of open lower limb fractures in the United Kingdom has evolved over last ten years with introduction major trauma networks (MTNs), publication standards care and wide acceptance a combined orthopaedic plastic surgical approach to management. aims this study were report recent changes outcome tibial following implementation these changes.Data on all patients an fracture presenting centre between 2011 2012 collected prospectively. treatment outcomes 65 Gustilo Anderson Grade III...
Several international calls have been made for evidence-based patient-reported outcome measure (PROM) implementation gender-affirming care. The Practical Guide to Implementing PROMs in Gender-Affirming Care (PG-PROM-GAC) is a resource which can help guide PROM efforts, developed using three-phase participatory research approach with transgender and gender-diverse (TGD) patients healthcare professionals. However, thoughts perspectives from TGD professionals on the PG-PROM-GAC need be investigated.
Objectives Patient and healthcare professional perspectives are needed to develop a gender-affirming care patient-reported outcome measure (PROM) implementation plan. We aimed identify top considerations relevant PROM from patient perspectives. Design, settings participants This qualitative study conducted in the UK between January April 2023 includes focus groups with sample diverse age gender identity, role. Established methods science Consolidated Framework for Implementation Research...
Surgery for nail bed injuries in children is common. One of the key surgical decisions whether to replace plate following repair. The aim this RCT was assess clinical effectiveness and cost-effectiveness repair with fingernail replacement/substitution compared without replacement.A two-arm 1 : parallel-group open multicentre superiority performed across 20 secondary-care hospitals UK. co-primary outcomes were surgical-site infection at around 7 days after surgery cosmetic appearance summary...
Importance The Practical Guide to Implementing PROMs in Gender-Affirming Care (PG-PROM-GAC) is an evidence-based resource, which was developed response international calls for improved patient-reported outcome measure (PROM) implementation gender-affirming care. PG-PROM-GAC has the potential improve PROM implementation; however, its real-world effectiveness not yet been investigated. Objective Investigate and fidelity of three strategies from a gender clinic setting. Design Interrupted time...
Objective Assess acceptability, appropriateness and feasibility of the Practical Guide to Implementing patient-reported outcome measures (PROMs) in Gender-Affirming Care (PG-PROM-GAC) from a sample patients healthcare professionals. Design Cross-sectional study conducted August–October 2023. Setting Participants were recruited National Health Service (NHS) gender clinic. Patient participants seeking care professionals working at an NHS clinic eligible for participation. The PG-PROM-GAC was...
Health can never be adequately protected by health services without the active understanding and involvement of communities whose is at stake. For attaining Universal Coverage, community participation important, as their role helps in sustained efforts, collaboration, a commitment to addressing underlying social determinants health, leading equity healthcare. Traditional Indian society cut across rigid religion caste lines, appropriate for each group has been serious obstacle securing...
To investigate the role of proinflammatory cytokines, vascular endothelial growth factor (VEGF), matrix metalloproteinases (MMPs), and tissue inhibitor 1 (TIMP-1) in destruction tendons by tenosynovium rheumatoid arthritis (RA).Synovial specimens were obtained from encapsulating (n = 17), invasive 13), wrist joints 17) 18 RA patients undergoing extensor tenosynovectomy. Synovial membrane cells dissociated connective enzyme digestion cultured vitro for 48 hours, harvested supernatants assayed...
There are a number of site-specific patient-reported outcome measures (PROMs) for hand conditions used in clinical practice and research assessing the efficacy surgical nonsurgical interventions. The most commonly hand-relevant PROMs as follows: Disabilities Arm, Shoulder Hand (DASH), QuickDASH (qDASH), Michigan Questionnaire (MHQ), Patient Evaluation Measure (PEM), Upper Extremity Functional Index (UEFI), Duruoz (DHI). has been no systematic evaluation published psychometric properties...