A5090121379- Aortic Disease and Treatment Approaches
- Social Media in Health Education
- Anatomy and Medical Technology
- Aortic aneurysm repair treatments
- Dementia and Cognitive Impairment Research
- Surgical Simulation and Training
- Connective tissue disorders research
- Cardiac, Anesthesia and Surgical Outcomes
- Simulation-Based Education in Healthcare
- Peripheral Artery Disease Management
- Lipoproteins and Cardiovascular Health
- Mobile Health and mHealth Applications
- Mental Health Treatment and Access
- Protease and Inhibitor Mechanisms
- Innovations in Medical Education
- Peptidase Inhibition and Analysis
- Traumatic Brain Injury Research
- E-Learning and COVID-19
- Tracheal and airway disorders
- Digital Mental Health Interventions
- Health Literacy and Information Accessibility
- Congenital Heart Disease Studies
- Older Adults Driving Studies
- Context-Aware Activity Recognition Systems
- Family Caregiving in Mental Illness
University of Michigan
2019-2024
Michigan Medicine
2021
Stanford University
2015-2019
Washington University in St. Louis
2019
Palm Research Center
2015
Abstract Aortic root aneurysm formation is a cardinal feature of Marfan syndrome (MFS) and likely TGF‐β driven via Smad (canonical) ERK (non‐canonical) signalling. The current study assesses human MFS vascular smooth muscle cell (SMC) phenotype, focusing on individual contributions by ERK, with Notch3 signalling identified as novel compensatory mechanism against TGF‐β‐driven pathology. Although significant activation mixed contractile gene expression patterns were observed traditional...
Background Statins reduce aneurysm growth in mouse models of Marfan syndrome, although the mechanism is unknown. In addition to reducing cholesterol, statins block farnesylation and geranylgeranylation, which participate membrane‐bound G‐protein signaling, including Ras. We dissected prenylation pathway define effect on reduction. Methods Results Fbn1 C1039G/+ mice were treated with (1) pravastatin (HMG‐CoA [3‐hydroxy‐3‐methylglutaryl coenzyme A] reductase inhibitor), (2) manumycin A ( MA ;...
Three-dimensional (3-D) printing offers an innovative option to produce clinical simulators because of its low production costs and widespread availability. We aimed develop a low-cost, 3-D printed knot-tying simulator that overcomes the barriers students face in self-directed skills development.
Mindstep is an app that aims to improve dementia screening by assessing cognition and risk factors. It considers important clinical factors, including prodromal symptoms, mental health disorders, differential diagnoses of dementia. The 9-item Patient Health Questionnaire for depression (PHQ-9) the 7-item Generalized Anxiety Disorder Scale (GAD-7) are widely validated commonly used scales in anxiety respectively. Shortened versions both (PHQ-2/GAD-2) have been produced.We sought develop a...
Clinical simulators are an important resource for medical students seeking to improve their fundamental surgical skills. Three-dimensional (3-D) printing offers innovative method create due its low production costs and reliable fidelity. We aimed validate a 3-D printed knot-tying simulator named Nodo-Tie. designed integrated with series of challenges designated video curriculum made accessible via quick-response (QR) code. The Nodo-Tie, which less than $1 print assemble, was distributed...
Objective: Our team set out to design and develop a low-cost 3D-printed liver transplant simulator. Design: The simulator comprises recipient body cavity the filled-fabric liver. Results: Validators perceived model as valuable education, noted that they would use at their institution desired integrate into curriculum. In addition, was rated highly for ease of (3.6/4), physical attributes (3.2/4) user experience (4.4/5). Conclusion: transplantation in multi-institutional validation supports...
Itai Palmon
Introduction: Enhanced TGF-β signaling drives aortic root aneurysm development in Marfan syndrome (MFS) via the non-canonical (ERK) pathway murine models, but ERK not been studied human tissue. Conversely, blockade of canonical (Smad) is detrimental MFS mice. Recently, TGF-β-induced increases smooth muscle cell (SMC) contractile genes and collagen I (COL1) expression have proposed to lead stiffness dilatation MFS. Hypothesis: We hypothesized that enhanced tissue dictates predilection develop...
Introduction Low-density lipoprotein cholesterol (LDL) is a known contributing factor to atherosclerotic cardiovascular disease (ASCVD) and primary therapeutic target for medical management of ASCVD. Non-high-density (non-HDL) has recently been identified as secondary but not yet widely used in vascular surgery patients. We sought assess if patients were undertreated per non-HDL guidelines. Methods This was an observational study that single-center database identify cohort adult who received...
<sec> <title>BACKGROUND</title> Mindstep is an app that aims to improve dementia screening by assessing cognition and risk factors. It considers important clinical factors, including prodromal symptoms, mental health disorders, differential diagnoses of dementia. The 9-item Patient Health Questionnaire for depression (PHQ-9) the 7-item Generalized Anxiety Disorder Scale (GAD-7) are widely validated commonly used scales in anxiety respectively. Shortened versions both (PHQ-2/GAD-2) have been...