A5084018767- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Migraine and Headache Studies
- Dementia and Cognitive Impairment Research
- Mental Health Treatment and Access
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Glioma Diagnosis and Treatment
- Glaucoma and retinal disorders
- Functional Brain Connectivity Studies
- Topic Modeling
- Emergency and Acute Care Studies
- Traumatic Brain Injury Research
- Psychosomatic Disorders and Their Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Digital Mental Health Interventions
- Frailty in Older Adults
- Religion, Spirituality, and Psychology
- Machine Learning in Materials Science
- History of Medical Practice
- Biomedical Text Mining and Ontologies
- Airway Management and Intubation Techniques
- Machine Learning in Bioinformatics
- Retinal and Macular Surgery
- Nerve Injury and Rehabilitation
University College London
2016-2024
National Hospital for Neurology and Neurosurgery
2016-2024
University College London Hospitals NHS Foundation Trust
2022-2024
University College Hospital
2023
Wellcome / EPSRC Centre for Interventional and Surgical Sciences
2020-2022
University of London
2022
Universidad de Londres
2022
Imperial College London
2022
Epilepsy Research UK
2020-2021
University College Lahore
2021
Semiology describes the evolution of symptoms and signs during epileptic seizures contributes to evaluation individuals with focal drug-resistant epilepsy for curative resection. varies in complexity from elementary sensorimotor arising primary cortex complex behaviours automatisms emerging distributed cerebral networks. Detailed semiology interpreted by expert epileptologists may point towards likely site seizure onset, but this process is subjective. No study has captured variances...
Importance Brain fog is associated with significant morbidity and reduced productivity gained increasing attention after COVID-19. However, this subjective state has not been systematically characterised. Objective To characterise self-reported brain fog. Design We studied the cross-sectional associations between 29 a priori variables presence of “brain fog.” The were grouped into four categories: demographics, symptoms functional impairments, comorbidities potential risk factors (including...
Background: Epilepsy affects 50 million people worldwide and a third are refractory to medication. If discrete cerebral focus or network can be identified, neurosurgical resection curative. Most excisions in the temporal-lobe, more likely result seizure-freedom than extra-temporal resections. However, less half of patients undergoing surgery become entirely seizure-free. Localizing epileptogenic-zone individualized outcome predictions difficult, requiring detailed evaluations at specialist...
Qualitative studies following Brachial Plexus Injury (BPI) suggest that return to employment has a major influence on life satisfaction and psychological well-being. However, few have focused work BPI. The physical strain intensity of an occupation may the ability individual employment. This study aimed provide information about impact workload status
Following a concussion, approximately 15% of individuals experience persistent symptoms that can lead to functional deficits. However, underlying symptom-clusters persist beyond 12 months have not been adequately characterized, and their relevance deficits are unclear. The aim this study was characterize the clusters prolonged post-concussive lasting more than months, investigate association with impairments.Although hierarchical clustering is ideally suited in evaluating subjective symptom...
Mindstep is an app that aims to improve dementia screening by assessing cognition and risk factors. It considers important clinical factors, including prodromal symptoms, mental health disorders, differential diagnoses of dementia. The 9-item Patient Health Questionnaire for depression (PHQ-9) the 7-item Generalized Anxiety Disorder Scale (GAD-7) are widely validated commonly used scales in anxiety respectively. Shortened versions both (PHQ-2/GAD-2) have been produced.We sought develop a...
A 40-year-old woman presented with a side-locked headache autonomic features, which then switched sides before reverting to the original side. The atypical features of side swapping, partial response indometacin and abnormal optic disc appearances ultimately led diagnosis recurrent posterior scleritis. We discuss differential trigeminal cephalgias its secondary causes, provide practical pointers for investigation management.
Abstract Background Digital health technologies are increasingly being used to monitor, assess, and treat depressive symptoms in the community. However, many such rely on screening tools which were originally designed for use primary care clinics, as Patient Health Questionnaire (PHQ-9). These scales symptom-focused do not capture wider experiences of patient. We developed a new screen assessing digital setting. Named Mindstep Mood Cause Examination (MMCE), it was replicate predictive...
Integrated care systems join up health and services, so that people have the support they need, in right place, at time. The aims include improving outcomes healthcare, tackling inequalities access enhancing productivity value for money. This is needed neuroscience as traditional delivery of inefficient, outdated expensive, can involve complex referral pathways long waiting times. In preparation formation integrated system (ICS), a novel innovative collaboration across multiple NHS trusts...
There are various models for acute neurology services in the UK, with considerable variation practice. Patients often admitted unnecessarily review, leading to delay diagnosis and treatment. Alternative models, such as Neurology Same Day Emergency Care service (Neuro-SDEC) at University College London Hospital provide a pathway that can prevent admissions streamline patient care. Headache is one of commonest presenting symptoms neurology. This study compared impact Neuro-SDEC on care...
Differentiating between peripheral and central causes of acute vertigo remains a clinical obstacle in the setting. Despite availability several validated diagnostic algorithms adoption implementation these tools is low because most emergency physicians are unfamiliar with them. Embedding an service within setting may help improve workup patients presenting this specific symptomatology have significant economic benefits, such as avoidance hospital admissions, reduction unnecessary...
Around one third of epilepsies are drug-resistant. For these patients, seizures may be reduced or cured by surgically removing the epileptogenic zone (EZ), which is portion brain giving rise to seizures. If noninvasive data not sufficiently lateralizing localizing, EZ need localized precise implantation intracranial electroencephalography (iEEG) electrodes. The choice iEEG targets influenced clinicians' experience and personal knowledge literature, leads substantial variations in strategies...
Background and aim Studies have demonstrated the role of magnesium on acute migraine attacks prophylaxis via voltage-dependent blockade N-methyl-D-aspartate (NMDA)-coupled channels. Our was to study tolerability intravenous (IV) in treatment Emergency Department (ED) Same Day Care (SDEC) unit University College Hospital, London. Methods We performed a non-randomised open-label trial establish safety IV sulfate. Patients were recruited from ED or SDEC hospital after being reviewed by...
Background and aim 5-10% of emergency department (ED) presentations are primarily neurological. We investigated the impact introduction an acute neurology service to ED, using same day care (SDEC) model. Methods performed a retrospective review consecutive referrals consultant-led at University College London Hospital during weekday afternoons from 5th May 2021 20th Jan 2022. Results Of 664 Neurology referrals, female sex was more common than male (60% vs 35.8%, p<0.0001, Fig. 1). Most...
Introduction Functional Neurological Disorder (FND) is common and can lead to multiple emergency department (ED) presentations unnecessary investigation. Early identification intervention have been shown reduce health care costs re-presentation acute services by more than 50%1. We created a pilot model provide early access multi-disciplinary FND team for patients assessed the ED-embedded neurology (Stroke or Neurology SDEC pathway) new diagnosis of FND. The MDT provided with individualised...
SDEC is the provision of same day care for emergency patients who would otherwise be admitted to hospital. Embedded within UCLH Emergency Department (ED), cases are referred consultant review. We aimed determine whether a Neurology (N-SDEC) service have beneficial impact at UCLH. The has run weekday neurologist-led since May 2021. supported by nurse practitioner. Investigations arranged via dedicated slots. patient then nurse-led telephone follow-up. sees approximately 100 neurology...
The Clinical Dementia Rating (CDR) and Mini-Mental State Examination (MMSE) are useful screening tools for mild cognitive impairment (MCI). However, these tests require qualified in-person supervision the CDR can take up to 60 min complete. We developed a digital test (M-CogScore) that be completed remotely in under 5 without supervision. set out validate M-CogScore head-to-head comparisons with MMSE.To ascertain validity of M-CogScore, we enrolled participants as healthy controls or...
Minority ethnic identification between physician and patient can reduce communication access barriers, improve physician-patient relationship, trust, health outcomes. Religion influences beliefs, behaviours, treatment decisions, Ethically contentious dilemmas in decisions are often entangled with religious beliefs. They feature more medical specialties such as Anaesthesia & Intensive Care, issues including informed consent for surgery, organ donation, transplant, transfusion, end-of-life...