A5070275005- Nerve Injury and Rehabilitation
- Nerve injury and regeneration
- Peripheral Nerve Disorders
- Orthopedic Surgery and Rehabilitation
- Spinal Cord Injury Research
- COVID-19 Clinical Research Studies
- Elbow and Forearm Trauma Treatment
- Cardiac Structural Anomalies and Repair
- Stroke Rehabilitation and Recovery
- Peptidase Inhibition and Analysis
- Prosthetics and Rehabilitation Robotics
- Botulinum Toxin and Related Neurological Disorders
- Hereditary Neurological Disorders
- Muscle activation and electromyography studies
- Long-Term Effects of COVID-19
- Cardiac Health and Mental Health
- Cerebral Palsy and Movement Disorders
- Neurogenesis and neuroplasticity mechanisms
- Cardiovascular and exercise physiology
- Antifungal resistance and susceptibility
- Musculoskeletal pain and rehabilitation
- Orthopedic Infections and Treatments
- Signaling Pathways in Disease
- Cardiac pacing and defibrillation studies
- Cardiac tumors and thrombi
Sparrow Hospital
2021-2024
Michigan State University
2021-2024
MemorialCare Health System
2024
Bronx Psychiatric Center
2024
University College London
2016-2023
Royal National Orthopaedic Hospital
2016-2023
Nerve Centre
2019-2023
Sparrow Health System
2020-2023
Stanmore College
2020
University of Strathclyde
2018
To counter the many disadvantages of prolonged wheelchair use, patients with spinal cord injuries (SCI) are beginning to turn towards robotic exoskeletons. However, we currently unaware magnitude and distribution forces acting between user exoskeleton. This is a critical issue, as SCI have an increased susceptibility skin lesions pressure ulcer development. Therefore, developed real-time force measuring apparatus, which was placed at physical human-robot interface (pHRI) lower limb...
Abstract Nerve regeneration is a key biological process in those recovering from neural trauma. From animal models it known that the regenerative capacity of peripheral nervous system (PNS) relies heavily on remarkable ability Schwann cells to undergo phenotypic shift myelinating phenotype one supportive regeneration. In rodents, great deal about molecules control this process, such as transcription factors c-Jun and early growth response protein 2 (EGR2/KROX20), or mark cellular changes...
Spinal cord injury (SCI) typically manifests with a loss of sensorimotor control the lower limbs. In order to overcome some disadvantages chronic wheelchair use by such patients, robotic exoskeletons are an emerging technology that has potential transform lives patients. However, there number points contact between robot and user, which lead interaction forces. recent study, authors have shown peak forces particularly prominent at anterior aspect right leg. This study uses similar...
Improvements in the evaluation of outcomes following peripheral nerve injury are needed. Recent studies have identified muscle fatigue as an inevitable consequence reinnervation. This study aimed to quantify and characterize within a standardized surgical model reinnervation.This retrospective cohort included 12 patients who underwent Oberlin transfer attempt restore flexion elbow brachial plexus injury. There were ten men two women with mean age 45.5 years (27 69). The follow-up was 58...
This case report explores the complexities involved in diagnosis and management of asymptomatic mitral regurgitation (MR) a 64-year-old male presenting with an incidental systolic murmur. Torrential MR flail valve (MV) segments was identified through comprehensive imaging clinical evaluation, including echocardiography catheterization. The discussion highlights nuances surgical timing, emphasizing importance tailored approaches based on left ventricular (LV) function dilation. sheds light...
Optimal functional recovery following peripheral nerve injuries (PNIs) is dependent upon early recognition and prompt referral to specialist centres for appropriate surgical intervention. Technologies which facilitate the detection of PNI would allow faster rates encourage improvements in patient outcomes. Serum Neurofilament light chain (NfL) measurements are cheaper perform, easier access interpret than many conventional methods used injury diagnosis, such as electromyography and/or...
Qualitative studies following Brachial Plexus Injury (BPI) suggest that return to employment has a major influence on life satisfaction and psychological well-being. However, few have focused work BPI. The physical strain intensity of an occupation may the ability individual employment. This study aimed provide information about impact workload status
Peripheral Nerve Injury (PNI) is common following blunt or penetrating trauma with an estimated prevalence of 2% among the population. The resulting economic and societal impacts are significant. regeneration a key biological process in those recovering from neural trauma. Real Time-quantitative Polymerase Chain Reaction (RT-qPCR) RNA sequencing (RNA seq) investigative methods that often deployed by researchers to characterize cellular molecular mechanisms underpin this process. However,...
Abstract The development of outcome measures that can track the recovery reinnervated muscle would benefit clinical investigation new therapies which hope to enhance peripheral nerve repair. primary objective this study was assess validity volumetric Magnetic Resonance Imaging (MRI) as an measure reinnervation by testing its reproducibility, responsiveness and relationship with indices muscular function. Over a 3-year period 25 patients who underwent transfer reinnervate elbow flexor muscles...
A coronary artery aneurysm (CAA) denotes a localized dilation of the artery, while fistula signifies an aberrant connection between and cardiac chamber or adjacent vessel. Here, we present case study 68-year-old female with previously diagnosed right artery-to-right atrial concomitant multiple aneurysms. Initially asymptomatic, patient subsequently manifested fibrillation. Management involved augmenting patient's home regimen metoprolol tartrate, followed by successful cardioversion...
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, yet they come with a spectrum of immune-related adverse events, including cardiac complications. We present the case 72-year-old male metastatic renal cell carcinoma who developed complete heart block and ventricular arrhythmias following pembrolizumab therapy. Despite no evidence myocarditis, patient's condition rapidly deteriorated, ultimately resulting in his demise. This underscores critical need for vigilance...
A male patient in his 60s, with a history of tobacco use, presented fever, weight loss, and cough, was ultimately diagnosed histoplasmosis. Initial treatment itraconazole (ITZ) led to symptom improvement. However, two months later, he returned lower extremity swelling dyspnea. Imaging showed pleural effusions reduced ejection fraction, suggesting itraconazole-induced cardiac toxicity. Transition voriconazole initiation guideline-directed medical therapy improved symptoms. This case report...
Abstract Introduction Improved outcome measures of muscle reinnervation would facilitate clinical translation new therapies which hope to enhance human peripheral nerve repair. Valid should be receptive the biological process and correlate with assessments muscular function. This study investigated responsiveness volumetric MRI its relationship indices Method Twenty-five patients who underwent transfer reinnervate elbow flexor muscles were followed-up at a median time 258 days (-86 1698...