A5039894397- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Tracheal and airway disorders
- Aortic aneurysm repair treatments
- Mechanical Circulatory Support Devices
- Infective Endocarditis Diagnosis and Management
- Organ Transplantation Techniques and Outcomes
- Pulmonary Hypertension Research and Treatments
- Congenital Diaphragmatic Hernia Studies
- Renal Transplantation Outcomes and Treatments
- Drug Transport and Resistance Mechanisms
- Nitric Oxide and Endothelin Effects
- Helicobacter pylori-related gastroenterology studies
- Cardiac, Anesthesia and Surgical Outcomes
- Statistical Methods and Bayesian Inference
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Statistical Methods and Inference
- Heart Failure Treatment and Management
- Advanced Causal Inference Techniques
- Vascular Anomalies and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
Boston Children's Hospital
2021-2025
Pamela Youde Nethersole Eastern Hospital
2025
Harvard University
2021-2024
Boston Children's Museum
2021-2023
Stanford University
2015-2022
Vertex Pharmaceuticals (United Kingdom)
2019
Vertex Pharmaceuticals (United States)
2019
Maastricht University
2017
Cardiovascular Institute of the South
2017
Otto-von-Guericke University Magdeburg
2017
In patients undergoing aortic-valve or mitral-valve replacement, either a mechanical biologic prosthesis is used. Biologic prostheses have been increasingly favored despite limited evidence supporting this practice.We compared long-term mortality and rates of reoperation, stroke, bleeding between inverse-probability-weighted cohorts who underwent primary replacement with in California the period from 1996 through 2013. Patients were stratified into different age groups on basis valve...
In patients with end-stage heart failure (ESHF) who are candidates for isolated transplant (HRT), dialysis dependence (DD) is considered an indication combined heart-kidney transplantation (HKT). HKT remains controversial in ESHF nondialysis-dependent renal insufficiency (NDDRI). Using United Network Organ Sharing data, we examined the cumulative incidences of and mortality DD NDDRI waitlisted or HRT. all groups, 3-month waitlist was dismal: 31% 21% HRT- HKT-listed 12% 7% NDDRI. Five-year...
Background— Medical treatment of initially uncomplicated acute Stanford type-B aortic dissection is associated with a high rate late adverse events. Identification individuals who potentially benefit from preventive endografting highly desirable. Methods and Results— The association computed tomography imaging features events was retrospectively assessed in 83 patients dissection, followed over median 850 (interquartile range 247–1824) days. Adverse were defined as fatal or nonfatal rupture,...
The feasibility and effectiveness of delaying surgery to transfer patients with acute type A aortic dissection-a catastrophic disease that requires prompt intervention-to higher-volume hospitals is unknown. We investigated the hypothesis regionalizing care at high-volume for dissections will lower mortality. further decomposed this into subparts, investigating isolated effect receiving a versus low-volume facility.
Whether a second arterial conduit improves outcomes after multivessel coronary artery bypass grafting remains unclear. Consequently, conduits other than the left internal thoracic are seldom used in United States.Using state-maintained clinical registry including all 126 nonfederal hospitals California, we compared all-cause mortality and rates of stroke, myocardial infarction, repeat revascularization, sternal wound infection between propensity score-matched cohorts who underwent primary,...
To evaluate the effect of visceral, renal, or peripheral malperfusion on outcome acute type A aortic dissection.We performed a retrospective review dissection experience at Stanford Hospital between January 2005 and December 2015. Inverse probability weighting was used to account for differences patients who experienced syndromes those did not. Weighted logistic regression in-hospital mortality, midterm survival assessed with restricted mean time weighted Cox regression. Reintervention death...
Management of the aortic root is a challenge for surgeons treating acute type A dissection.We performed retrospective review dissection experience at Stanford Hospital between 2005 and 2015 identified patients who underwent either limited repair or replacement. Differences in baseline characteristics were balanced with inverse probability weighting to estimate average treatment effect on controls. Weighted logistic regression was used evaluate in-hospital mortality. Cox proportional hazards...
Although controlled donation after circulatory determination of death (cDCDD) could increase the supply donor lungs within United States, yield from cDCDD donors remains low compared with neurologic (DNDD). To explore reason for lung donors, Scientific Registry Transplant Recipient data were used to assess impact quality on utilization by fitting a logistic regression model. The relationship between center volume and use was assessed, distance hospital calculated status. survival using...
Despite its heterogeneity, there is currently limited data in pleural infection phenotyping. Using fluid characteristics, can be classified into microbiological-positive (MPPI) and microbiological-negative (MNPI). This study aimed to evaluate the prognostic significance of microbiological positivity infection, performance RAPID (renal, age, purulence, source, dietary factor) score these subgroups. Consecutive patients hospitalized for over a 10-year period two acute-care hospitals Hong Kong...
The optimal conduit for valve-sparing aortic root replacement is still debated, with several variations available, ranging from straight tubular grafts to Valsalva grafts. Benefits of neosinus reconstruction include enhanced flow profiles and improved hemodynamics. Curiously, however, some clinical data suggest that may have greater long-term durability. In this study, we hypothesized help maintain the native cylindrical position valve commissures radially, resulting in preserved leaflet...
Phorbol esters activate protein kinase C and induce contraction in vascular smooth muscle. The role of Ca the sensitivity this response to nitrovasodilators were evaluated rabbit aortic rings. dibutyrate (PDB) (0.01-10 microM) elicited a concentration-dependent Responses PDB salt solution (SS) containing 2.54 mM CaCl2 not significantly different from those SS 0 2 ethylene glycol bis(beta-aminoethyl ether)-N,N'-tetraacetic acid. Contractions (1 zero reduced by depletion...
SCH 28080 (2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile) is a novel antiulcer agent which has both antisecretory and cytoprotective activities. The ED50 values in the pylorus-ligated rat were 3.7 mg/kg p.o. 2.8 i.p., being 7 10 times more potent than cimetidine, respectively. In dogs, was effective inhibiting acid secretion stimulated by histamine (ED50 of 0.09 i.v. 4.4 p.o.), dimaprit, pentagastrin, insulin feeding. activity demonstrated inhibition ethanol-induced gastric...
Platelets have been implicated in the pathophysiology of ischemia-reperfusion injury. In this study, antiplatelet effects cyclic GMP (cGMP)- and AMP (cAMP)-mediated agents were evaluated renal ischemia pentobarbital-anesthetized rats. Renal was induced by unilateral occlusion left artery (40 min) followed reperfusion (30 with contralateral kidney serving as control. 111Indium-labeled platelets, drugs or vehicle administered 30 min before induction ischemia. Occlusion for 20, 40 60 resulted a...
The effect of furosemide on gentamicin excretion and tissue accumulation was studied with clearance techniques in anesthetized rats, at two different infusion rates saline or Ringer solution. Gentamicin (∼20 mg/kg) administered by constant intravenous over a period 3 h. With the low fluid rate, (25 mg/kg intravenously) caused severe reduction glomerular filtration rate diminished urinary output gentamicin. Serum renal levels antibiotic were significantly elevated. High prevented decline near...