A5078533992- Cardiac Arrest and Resuscitation
- Extracellular vesicles in disease
- Traumatic Brain Injury and Neurovascular Disturbances
- Pharmacological Effects and Toxicity Studies
- Intestinal and Peritoneal Adhesions
- Gallbladder and Bile Duct Disorders
- Epilepsy research and treatment
- Intestinal Malrotation and Obstruction Disorders
- Infection Control and Ventilation
- Cardiac Valve Diseases and Treatments
- Advanced MRI Techniques and Applications
- Esophageal and GI Pathology
- Mental Health and Patient Involvement
- Abdominal Trauma and Injuries
- Cardiovascular Function and Risk Factors
- Gastrointestinal disorders and treatments
- Cardiac Structural Anomalies and Repair
- Academic Publishing and Open Access
- Climate Change and Health Impacts
- Signaling Pathways in Disease
- Medical Imaging Techniques and Applications
- Appendicitis Diagnosis and Management
- Boron Compounds in Chemistry
- Biliary and Gastrointestinal Fistulas
- Mesenchymal stem cell research
Yale University
2022-2024
University of Michigan
2019-2021
Michigan Medicine
2020-2021
Healthcare systems have postponed medical volunteering services in response to the COVID-19 pandemic. However, much of aid provided by these volunteers is crucial patient care and hospital functioning American healthcare system. The adoption online video conferencing platforms healthcare-telehealth-offers a novel solution for during this Virtual can alleviate pressures on workers, enhance experiences, reduce risk viral infection provide sense normalcy patients families. Although further...
BACKGROUND Early single-dose treatment with human mesenchymal stem cell–derived exosomes promotes neuroprotection and blood-brain barrier integrity in models of traumatic brain injury (TBI) hemorrhagic shock (HS) swine. The impact an early single dose on late survival (7 days), however, remains unknown. We sought to evaluate the exosome neurologic outcomes, lesion size, inflammatory cytokines, apoptotic markers, mediators neural plasticity a 7-day model. METHODS Yorkshire swine were...
Cell-based therapies using mesenchymal stem cell derived extracellular vesicles (EVs) improve neurologic outcomes in animal models of traumatic brain injury (TBI), stroke, and hemorrhage. Using a porcine 7-day survival model TBI hemorrhagic shock (HS), we previously demonstrated that EV-treatment was associated with reduced lesion size, severity score, cerebral inflammation. However, the underlying cellular genomic mechanisms remain poorly defined. We hypothesize EV treatment modulates...
Bowel obstructions can have a variety of causes, including impacted feces, adhesions, volvulus, non-internal hernias, and in rare cases internal hernias.We report 63-year-old woman who presented to the emergency department with severe abdominal pain, nausea, vomiting, obstructive symptoms that had started 12 hours earlier.A computed tomographic scan abdomen pelvis showed right hernia cecal bascule traversing through foramen Winslow, concerning for closed-loop obstruction.The patient...
Acute hemorrhagic cholecystitis is a rare, life-threatening condition that can be further complicated by perforation of the gallbladder.We describe patient with clinical and radiologic findings acute gallbladder rupture massive intra-abdominal bleeding.Our 67-year-old male who presented an ischemic stroke was treated early tissue plasminogen activator.His hospital course fall requiring posterior spinal fusion surgery.He recovered well, but several days later developed subxiphoid right upper...
Abstract Background Accurate conflict of interest (COI) information is essential for promoting transparency and trust in research. We aim to assess COI disclosure patterns monoclonal antibodies (MABs) research chronic rhinosinusitis with nasal polyposis (CRSwNP) using the Open Payments Database (OPD). Methods Studies on FDA‐approved MABs CRSwNP (dupilumab, omalizumab, mepolizumab) published between 2019 2021 at least one US author were identified through PubMed. Industry‐reported payments...
High-dose valproic acid (VPA) improves the survival and neurologic outcomes after asphyxial cardiac arrest (CA) in rats. We characterized pharmacokinetics, pharmacodynamics, safety of high-dose VPA a swine CA model to advance clinical translation.After 8 min untreated ventricular fibrillation CA, 20 male Yorkshire were resuscitated until return spontaneous circulation (ROSC). They block randomized receive placebo, 75 mg/kg, 150 or 300 mg/kg as 90-min intravenous infusion (n = 5/group)...
Myocardial infarction (MI) is often complicated by left ventricular (LV) remodeling and heart failure. We evaluated the feasibility of a multimodality imaging approach to guide delivery an imageable hydrogel assessed LV functional changes with therapy. Yorkshire pigs underwent surgical occlusions branches anterior descending and/or circumflex artery create anterolateral MI. hemodynamic mechanical effects intramyocardial in central infarct area (Hydrogel group,
Introduction: High-dose valproic acid (VPA) has been shown to improve the survival and neurologic outcomes in preclinical brain injury models including asphyxial cardiac arrest (CA) rats. However, its pharmacokinetics, pharmacodynamics, safety profiles large animal CA are unknown. Hypothesis: VPA can be safely administered after return of spontaneous circulation (ROSC) cross blood-brain barrier dose-dependently a swine model. Methods: After 8 minutes untreated ventricular fibrillation CA,...
Introduction: Respiratory infections can occur through the transmission of virus-containing aerosols from infected individuals. It remains unclear whether cardiac arrest (CA) resuscitation generates that have potential to transmit diseases including COVID-19. Hypothesis: In a swine CA model, chest compression and defibrillation generate (≤10 μm) could contain respiratory viruses. Methods: To simulate witnessed with bystander-initiated CPR, 3 female non-intubated underwent 4 minutes untreated...