A5074052443- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Tissue Engineering and Regenerative Medicine
- Cardiac Valve Diseases and Treatments
- Receptor Mechanisms and Signaling
- Advanced X-ray and CT Imaging
- Cardiac Fibrosis and Remodeling
- Electrospun Nanofibers in Biomedical Applications
- Cardiovascular Disease and Adiposity
- Cardiac Structural Anomalies and Repair
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Ischemia and Reperfusion
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Mesenchymal stem cell research
- Phosphodiesterase function and regulation
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Radiopharmaceutical Chemistry and Applications
- Pulmonary Hypertension Research and Treatments
- Muscle Physiology and Disorders
- Peptidase Inhibition and Analysis
- Cardiovascular and Diving-Related Complications
Yale University
2016-2025
Imaging Center
2015-2024
Soochow University
2023
Intermountain Healthcare
2023
University of Michigan–Ann Arbor
2023
Dana (United States)
2022
University of New Haven
2015-2019
University of Ottawa
2009-2018
Technical University of Denmark
2018
St. Paul's Hospital
2009
Abstract Diseases of ectopic calcification the vascular wall range from lethal orphan diseases such as generalized arterial infancy (GACI), to common hardening arteries associated with aging and calciphylaxis chronic kidney disease (CKD). GACI is a in which infants calcify internal elastic lamina their medium large expire cardiac failure neonates, while CKD ubiquitous patients renal failure. Both disorders are characterized by Mönckeburg’s sclerosis accompanied decreased concentrations...
Glutaredoxin-2 (Grx2) modulates the activity of several mitochondrial proteins in cardiac tissue by catalyzing deglutathionylation reactions. However, it remains uncertain whether Grx2 is required to control ATP output heart. Here, we report that plays a vital role modulating energetics and heart physiology mediating proteins. Deletion (Grx2(-/-)) decreased production complex I-linked substrates half wild type (WT) mitochondria. Decreased respiration was associated with increased I...
Characterizing left ventricular deformation and strain using 3D+time echocardiography provides useful insights into cardiac function can be used to detect localize myocardial injury. To achieve this, it is imperative obtain accurate motion estimates of the ventricle. In many analysis pipelines, this step often accompanied by a separate segmentation step; however, recent works have shown both tasks highly related complementary when optimized jointly. work, we present multi-task learning...
Abstract Angiotensin receptor blocker-neprilysin inhibitor (ARNi) therapy improves the prognosis of heart failure patients. However, mechanisms remain unclear. This study investigated biological effects ARNi with neprilysin sacubitril and angiotensin blocker valsartan on myocardial remodeling cardiac perfusion in experimental (HF) after infarction (MI). Male Lewis rats (10-weeks old) confirmed HF were randomized one-week post-MI to treatment vehicle (water), sacubitril/valsartan or...
Metabolic stress is an important cause of pathological atrial remodeling and fibrillation. AMPK a ubiquitous master metabolic regulator, yet its biological function in the atria poorly understood both health disease. We investigated impact atrium-selective cardiac deletion on electrophysiological structural mice. Loss expression caused changes properties ectopic activity prior to onset spontaneous Concomitant transcriptional downregulation connexins ion channel subunits manifested with...
Background— Collagen delivery matrices have been reported to improve the results of cell therapy, but knowledge their mechanisms action is limited. To evaluate whether a collagen matrix improves early engraftment posttransplantation, 2-[ 18 F]fluoro-2-deoxy- d -glucose ( F-FDG) was used label transplanted circulating progenitor cells (CPCs) and track them in vivo with positron-emission tomography. Methods Results— Efficiency F-FDG labeling CPC-concentration dependent r =0.61, P <0.001)...
A noninvasive and repeatable method for assessing mouse myocardial glucose uptake with <sup>18</sup>F-FDG PET Patlak kinetic analysis was systematically assessed using the vena cava image–derived blood input function (IDIF). <b>Methods:</b> Contrast CT computer modeling used to determine recovery coefficient. Vena IDIF (<i>n</i> = 7) compared left ventricular cavity IDIF, liver activity measured ex vivo at 60 min. The test–retest repeatability 9) of influx constant K<sub>i</sub> 10–40 min...
A commonly used treatment for open wounds, negative pressure wound therapy (NPWT) has recently been to optimize healing in the setting of surgically closed wounds; however, specific mechanisms action by which NPWT may benefit patients after surgery remain unknown. Using a swine model, current study investigates angiogenesis as candidate mechanism.Multiple excisional wounds were created on dorsa 10 male Yorkshire pigs and primary suture. The underwent with either dressing or control dressings...
The LabPET <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM</sup> is a fully digital avalanche photodiode (APD) based PET scanner designed for state-of-the- art molecular and genomic imaging of small animals. Two versions the were evaluated, having 3.75 (LabPET4) 7.5 cm axial FOV (LabPET8). detectors are made 2x2x10/12 mm xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> LYSO LGSO crystals assembled in phoswich pairs read out by an APD. After...
The energy spectrum for a cadmium zinc telluride (CZT) detector has low tail due to incomplete charge collection and intercrystal scattering. Due these solid-state effects, scatter would be overestimated if the conventional triple-energy window (TEW) method is used crosstalk corrections in CZT-based imaging systems. objective of this work develop correction (99m)Tc/(123)I dual-radionuclide dedicated cardiac SPECT system with pinhole collimators (GE Discovery NM 530c/570c).A tailing model was...
Injectable hydrogels are being widely explored for treatment after myocardial infarction (MI) through mechanical bulking or the delivery of therapeutics. Despite this interest, there have been few approaches to image upon injection identify their location, volume, and pattern delivery, features that important understand toward clinical translation. Using a hyaluronic acid (HA) hydrogel as an example, aim study is introduce radiopacity by encapsulating clinically used contrast agent...
Humans with an R302Q mutation in AMPKgamma(2) (the PRKAG2 gene) develop a glycogen storage cardiomyopathy characterized by familial form of Wolff-Parkinson-White syndrome and cardiac hypertrophy. This phenotype is recapitulated transgenic mice cardiomyocyte-restricted expression AMPKgamma(2)R302Q. Although considerable information known regarding the consequences harboring gamma(2)R302Q mutation, little about early signaling events that contribute to development this cardiomyopathy.To...
Cell therapy is expected to restore perfusion and improve function in the ischemic/infarcted myocardium; however, biological mechanisms local effects of transplanted cells remain unclear. To assess cell fate vivo, hexadecyl-4-[(18)F]fluorobenzoate ((18)F-HFB) labeling was evaluated for tracking human circulating progenitor (CPCs) with positron emission tomography (PET) compared commonly used 2-[(18)F]fluoro-2-deoxy-d-glucose ((18)F-FDG) method a rat myocardial infarction model. CPCs were...