A5023459116- IL-33, ST2, and ILC Pathways
- Gut microbiota and health
- Immune Response and Inflammation
- Spondyloarthritis Studies and Treatments
- Inflammatory Bowel Disease
- Pregnancy and Medication Impact
- Microbial Natural Products and Biosynthesis
- Immune responses and vaccinations
- Antibiotic Resistance in Bacteria
- Antimicrobial Resistance in Staphylococcus
- Bacterial Genetics and Biotechnology
- Cancer Immunotherapy and Biomarkers
- Vibrio bacteria research studies
- Inflammasome and immune disorders
- Vaccine Coverage and Hesitancy
- Clostridium difficile and Clostridium perfringens research
- Bacterial biofilms and quorum sensing
- Colorectal Cancer Treatments and Studies
- Pneumonia and Respiratory Infections
- Immune cells in cancer
- Complementary and Alternative Medicine Studies
- Antimicrobial Peptides and Activities
- Escherichia coli research studies
- Cardiac Health and Mental Health
- Plant Disease Resistance and Genetics
Weill Cornell Medicine
2021-2024
Rutgers, The State University of New Jersey
2018-2024
Rutgers New Jersey Medical School
2018-2024
Cornell University
2021-2024
New York Hospital Queens
2021-2024
Presbyterian Hospital
2024
NewYork–Presbyterian Hospital
2021-2024
Universidade do Porto
2011-2020
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2015-2020
Columbia University
2018-2019
Sulfasalazine is a prodrug known to be effective for the treatment of inflammatory bowel disease (IBD)-associated peripheral spondyloarthritis (pSpA), but mechanistic role gut microbiome in regulating its clinical efficacy not well understood. Here, 22 IBD-pSpA subjects with sulfasalazine identifies responders enriched Faecalibacterium prausnitzii and capacity butyrate production. Sulfapyridine promotes production transcription synthesis gene F. vitro, which suppressed by excess folate....
Maintaining balanced levels of IL-1β is extremely important to avoid host tissue damage during infection. Our goal was understand the mechanisms behind reduced pathology and decreased bacterial burdens in Ifnlr1-/- mice lung infection with Staphylococcus aureus. Intranasal S. aureus led significantly improved clearance, survival decrease proinflammatory cytokines airway including IL-1β. treated recombinant displayed increased lung. neutrophils from infected lungs were when compared WT mice....
<i>Acinetobacter baumannii</i> is an opportunistic pathogen that has recently emerged as a global threat associated with high morbidity, mortality, and antibiotic resistance. We determined the role of type I interferon (IFN) signaling in <i>A. infection. report can induce IFN response dependent upon TLR4-TRIF-IRF3 phagocytosis bacterium. Phase variants have reduced capsule, lead to enhanced TLR4-dependent induction. This was also observed capsule-deficient strain. However,...
Streptomyces secondary metabolism is strongly affected by oxygen availability. The increased culture aeration enhances pimaricin production in S. natalensis, however the excess of O2 consumption can lead to an intracellular ROS imbalance that harmful cell. adaptive physiological response natalensis upon addition exogenous H2O2 suggested modulation levels, through activation inducible catalase during late exponential growth phase, alter pimaricin. With construction defective mutants on...
Acinetobacter baumannii (A. baumannii) is an extremely versatile multidrug-resistant pathogen with a very high mortality rate; therefore, it has become crucial to understand the host response during its infection. Given importance of mice for modeling infection and their role in preclinical drug development, equal emphasis should be placed on use both sexes. Through our studies using murine model acute pneumonia A. baumannii, we observed that female were more susceptible Likewise, treatment...
Abstract Streptomyces are aerobic Gram-positive bacteria characterized by a complex life cycle that includes hyphae differentiation and spore formation. Morphological is triggered stressful conditions takes place in pro-oxidant environment, which sets the basis for an involvement of oxidative stress response this cellular process. Characterization phenotypic traits natalensis Δ katA1 (mono-functional catalase) catR (Fur-like repressor expression) strains solid medium revealed both mutants...
Environmental airborne antigens are central to the development of allergic asthma, but cellular processes that trigger disease remain incompletely understood. In this report, Schmitt et al. (https://doi.org/10.1084/jem.20231236) identify TNF-like protein 1A (TL1A) as an epithelial alarmin constitutively expressed by a subset lung cells, which is released in response microbial challenge and synergizes with IL-33 drive disease.
ABSTRACT Type III interferon signaling contributes to the pathogenesis of important human pathogen Staphylococcus aureus in airway. Little is known cellular factors this response. Using Ifnl2 -green fluorescent protein reporter mice combined with flow cytometry and depletion strategies, we demonstrate that alveolar macrophage primary producer lambda (IFN-λ) response S. Bone marrow chimeras showed reduced bacterial burden IFN-λ receptor (IFNLR1)-deficient recipient mice, indicative...
Staphylococcus aureus is a major cause of both community- and healthcare-acquired pneumonias. Inducible costimulator (ICOS) part the CD28 family proteins target for immune checkpoint therapy. We found ICOS highly expressed on activated CD4 cells in response to S. aureus. In absence ICOS, mice had improved survival pneumonia model with methicillin-resistant (MRSA) strain USA300 significant reductions bacterial burden nonlethal acute model. Infected Icos-/- several proinflammatory cytokines,...
The oxidative stress response is a key mechanism that microorganisms have to adapt changeling environmental conditions. Adaptation achieved by fine-tuned molecular extends its influence primary and secondary metabolism. In the past, role of intracellular redox status in biosynthesis tacrolimus Streptomyces tsukubaensis has been briefly acknowledged. Here, we investigate impact on S. tsukubaensis. Physiological characterization showed onset coincided with induction catalase activity....
Abstract Extracytoplasmic function (ECF) sigma factors are key transcriptional regulators that prokaryotes have evolved to respond environmental challenges. Streptomyces tsukubaensis harbours 42 ECFs reprogram stress-responsive gene expression. Among them, SigG1 features a minimal conserved ECF σ 2 –σ 4 architecture and an additional C-terminal extension encodes SnoaL_2 domain, which is characteristic for of group ECF56. Although proteins with such domain organisation widely found among...
Abstract Inflammatory changes play an important role in tumorigenesis, and patients with chronic inflammatory bowel disease (IBD) are at increased risk of developing colitis-associated cancer (CAC). Variants TNFSF15, the gene that encodes TL1A, associated more aggressive IBD advanced CRC. Here, we show TL1A signaling is required for tumorigenesis sufficient to promote CRC mouse models. group 3 innate lymphoid cells (ILC3) promotes GM-CSF dependent activation colonic neutrophils tumors...
Abstract A central feature of intestinal mucosal immune system is the ability enable antigen specific tolerance to gut bacteria. Genetic variants in TNFSF15 (which encodes protein TL1A) are linked inflammatory bowel disease and have implicated roles for TL1A regulating both T cell innate lymphoid cells (ILC), but how these cellular pathways coordinate a response limit inflammation not completely understood. Deletion receptor Tnfrsf25 (also called DR3), we demonstrate that signaling required...
Abstract Joint inflammation, or spondyloarthritis (SpA), is the most common extra-intestinal manifestation of inflammatory bowel disease (IBD), but specific role for therapies targeting SpA not well defined. One earliest medications used treatment IBD sulfasalazine (SAS). SAS a prodrug composed two chemical moieties, anti-inflammatory 5-aminosalicilate and antibiotic sulfapyridine. The efficacy in peripheral arthritis thought to depend on its “antibacterial” properties, however impact...
O propósito deste estudo foi verificar o efeito de 12 semanas treino multicomponente e destreino 10 na força máxima potência muscular dos membros inferiores idosos. Métodos: 22 idosos voluntários, praticantes hidroginástica (68,5 ± 5,1 anos) foram divididos em dois grupos: GE (n=14) GC (n=8). GE, para além das aulas hidroginástica, submetido a um semanal progressivo, com intensidades 50% - 85% 1RM 2 séries 6-18 reps. A aptidão avaliada através testes 20%, 40% 60% 1RM. Os mesmos realizados...
Abstract Intestinal inflammation associated with chronic inflammatory bowel disease (IBD) increases the risk of developing colitis-associated cancer (CAC), but cellular mechanisms driving CAC are not well defined. Polymorphisms in TNFSF15 (called TNF-like cytokine 1a or TL1A) highly IBD and aim this work is to evaluate a potential mechanistic role TL1A regulating CAC. Data from human atlas protein database revealed that present 50% colorectal tissue samples high expression correlated reduced...