A5015861319- Multiple Sclerosis Research Studies
- Advanced MRI Techniques and Applications
- Sarcoidosis and Beryllium Toxicity Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Advanced Neuroimaging Techniques and Applications
- Polyomavirus and related diseases
- Lanthanide and Transition Metal Complexes
- Peripheral Neuropathies and Disorders
- Autoimmune Neurological Disorders and Treatments
- Infectious Diseases and Tuberculosis
- Electron Spin Resonance Studies
- RNA regulation and disease
- Ultrasound and Hyperthermia Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Amyloidosis: Diagnosis, Treatment, Outcomes
- MRI in cancer diagnosis
- Systemic Lupus Erythematosus Research
- Cerebrovascular and genetic disorders
- CNS Lymphoma Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ultrasound Imaging and Elastography
- IgG4-Related and Inflammatory Diseases
- Alzheimer's disease research and treatments
Vanderbilt University Medical Center
2013-2025
University of California, San Francisco
2019-2024
Virginia Commonwealth University
2024
Billings Clinic
2021
University of Washington
2018-2021
Pulmonary and Critical Care Associates
2021
Brigham and Women's Hospital
2019
NYU Langone Health
2019
Massachusetts General Hospital
2017-2019
Harvard University
2019
Abstract Astrocytes and microglia, the two immune‐regulatory cells of central nervous system (CNS), are activated by a variety pathogens cytokines to elicit rapid transcriptional responses. This program activation is initiated set intracellular signaling cascades that includes mitogen‐activated protein kinase (MAPK), nuclear factor (NF) κB, Janus kinase/signal transducers activators transcription (JAK/STAT) pathways. study defines critical role NADPH oxidase(Phox)‐derived reactive oxygen...
Objective: To report on the clinical presentations, laboratory abnormalities, treatment and outcomes in 54 patients with neurosarcoidosis (NS).
The Neurosarcoidosis Consortium Consensus Group, an expert panel of physicians experienced in the management patients with sarcoidosis and neurosarcoidosis, engaged iterative process to define neurosarcoidosis develop a practical diagnostic approach suspected neurosarcoidosis. This aimed consensus clinical definition enhance care encourage standardization research initiatives that address this disease.The work collaboration included review manifestations establishment diagnosis disorder....
To describe clinical and imaging responses in neurosarcoidosis to infliximab, a monoclonal antibody against tumor necrosis factor-α.Investigators at 6 US centers retrospectively identified patients with CNS sarcoidosis treated including only definite or probable following rigorous exclusion of other causes.Of 66 (27 definite, 39 probable) infliximab for median 1.5 years, the mean age was 47.5 years initiation (SD 11.7, range 24-71 years); 56.1% were female; 62.1% white, 37.0% African...
<h3>Background</h3> Natalizumab (NTZ), a monoclonal antibody to human α<sub>4</sub>β<sub>1</sub>/β<sub>7</sub> integrin, is an effective therapy for multiple sclerosis (MS), albeit associated with progressive multifocal leukoencephalopathy (PML). Clinicians have been extending the dose of infusions hypothesis reducing PML risk. The aim study evaluate clinical consequences NTZ frequency infusion up 8 weeks 5 days. <h3>Methods</h3> A retrospective chart review in 9 MS centres was performed...
Abstract Chemical exchange saturation transfer (CEST) MRI is a molecular imaging method that has previously been successful at reporting variations in tissue protein and glycogen contents pH. We have implemented amide proton (APT), specific form of chemical imaging, high field (7T) used it to study healthy human subjects patients with multiple sclerosis. The effects static inhomogeneities were mitigated using water shift referencing center each z‐spectrum on voxel‐by‐voxel basis. Contrary...
Neurosarcoidosis is a rare granulomatous disease that can result in cranial neuropathy, chronic meningitis, and intracranial granuloma formation. Meningeal involvement may cause focal nodular enhancement simulate common base tumors. The objective of the current study to further define clinical features neurosarcoidosis large cohort patients, focusing on characteristics relevant skull surgeon.Retrospective series.Two tertiary academic referral centers.Consecutive patients diagnosed with...
The enthusiasm for natalizumab, a highly efficacious agent in the treatment of multiple sclerosis (MS), has been tempered by risks progressive multifocal leukoencephalopathy associated with its use, and strategies to minimize those are great interest. Extended interval dosing (EID) proposed as way maintain efficacy natalizumab while reducing exposure it. We reviewed cohort patients who received at 6-8-week intervals instead typical infusions every 4 weeks goal assess if on EID had an...
T2*-weighted multi-echo gradient-echo magnetic resonance imaging and its reciprocal R2* are used in brain due to their sensitivity iron content. In patients with multiple sclerosis who display pathological alterations myelin contents, the use of may offer a unique way untangle mechanisms disease. Coronal slices from 8 brains deceased were imaged using whole-body 7.0 Tesla MRI scanner. The scanning protocol included three-dimensional (3D) T2*-w 2D T2-w turbo spin echo (TSE) sequences....
Background: The clinical course of multiple sclerosis (MS) is mainly attributable to cervical and upper thoracic spinal cord dysfunction. High-resolution, 7T anatomical imaging the presented. Image contrast between gray/white matter lesions surpasses conventional, T 1 - 2 -weighted sequences at lower field strengths. Objective: To study healthy controls patients with MS using magnetic resonance 7T. Methods: Axial (C2–C5) *-weighted sagittal *-/spin-density-weighted images were acquired in 13...
Patients with multiple sclerosis present focal lesions throughout the spinal cord. There is a clinical need for non-invasive measurements of cord activity and functional organization in sclerosis, given cord's critical role disease. Recent reports spontaneous blood oxygenation level-dependent fluctuations using MRI suggest that, like brain, at rest organized into distinct, synchronized networks among grey matter regions, likely related to motor sensory systems. Previous studies looking...
The ability to evaluate pathological changes in the spinal cord multiple sclerosis (MS) is limited because T1 - and T2 -w MRI imaging are not sensitive biochemical vivo. Amide proton transfer (APT) chemical exchange saturation (CEST) can indirectly detect amide protons associated with proteins peptides, potentially providing more specificity. Here, we implement APT CEST cervical of healthy MS cohorts at 3T.APT was obtained a cohort 10 controls patients using novel respiratory correction...
Neurosarcoidosis poses a diagnostic and management challenge due to its rarity, phenotypic variability, lack of randomized controlled studies guide treatment selection. Recommendations for based on expert opinion are useful in clinical practice provide framework designing prospective studies. In this Delphi survey study, specialists with experience managing patients neurosarcoidosis were invited anonymously complete 2 surveys about key elements evaluation, diagnosis, treatment, monitoring,...
The mitogen-activated protein kinases (MAPKs) play a central role in mediating the activation and transcriptional responses of diverse cells, including glia. c-Jun N-terminal kinase (JNK), member MAPK family, is activated by variety stress proinflammatory signals turn phosphorylates its downstream substrates nuclear factors, leading to target genes. There are at least three subtypes JNK (i.e., JNKs 1–3) that may isoform-specific roles. This study examined isoforms induction inducible nitric...
High‐magnetic‐field (7 T) chemical exchange saturation transfer (CEST) MRI provides information on the tissue biochemical environment. Multiple sclerosis (MS) affects entire central nervous system, including spinal cord. Optimal CEST parameters found via simulation were implemented for in 10 healthy controls and patients with MS, results examined using traditional asymmetry analysis a Lorentzian fitting method. In addition, T 1 ‐ 2 *‐weighted images acquired lesion localization transmitted B...
Background: Cognitive impairment (CI) profoundly impacts quality of life for patients with multiple sclerosis (MS). Dysfunctional regulation glutamate in gray matter (GM) has been implicated the pathogenesis MS by post-mortem pathological studies and CI vivo magnetic resonance spectroscopy, yet GM pathology is subtle difficult to detect using conventional T 1 - 2 -weighted imaging (MRI). There a need high-resolution, clinically accessible techniques that probe molecular changes GM....
ABSTRACT BACKGROUND AND PURPOSE An imaging biomarker of myelin integrity is an unmet need in multiple sclerosis (MS). Selective inversion recovery (SIR) quantitative magnetization transfer (qMT) provides assays content the human brain. We previously translated SIR method to 7T and incorporated a rapid turbo field echo (TFE) readout for whole‐brain within clinically acceptable scan times. herein provide histological validation test vivo feasibility applicability SIR‐TFE protocol MS. METHODS...
Encephalitis is a significant cause of morbidity and mortality, yet causative factor identified in <50% cases.1 The most common causes are infectious (particularly herpes simplex virus [HSV]) autoimmune.2 Diagnosis the latter potentially treatable aided by detection serum or CSF an informative profile autoantibodies against neuronal intracellular proteins plasma membrane (e.g., voltage-gated potassium channel [VGKC] complex calcium channels [VGCC, P/Q-type N-type] growing list glutamate...
Interplay between susceptibility genes and environmental factors is considered important player in the genesis of multiple sclerosis (MS). Among factors, a role for an infectious pathogen has long been central to disease process. This opinion support both from epidemiological data findings immunological abnormalities spinal fluid that reflect immune response as yet undetermined antigen, possibly pathogen, cerebrospinal fluid. Our review will outline current understanding infection causation...