A5069580134- Thin-Film Transistor Technologies
- Nanowire Synthesis and Applications
- Silicon and Solar Cell Technologies
- ZnO doping and properties
- Semiconductor materials and devices
- Semiconductor materials and interfaces
- Ga2O3 and related materials
- Viral gastroenteritis research and epidemiology
- Silicon Nanostructures and Photoluminescence
- RNA modifications and cancer
- Immune Response and Inflammation
- Electrocatalysts for Energy Conversion
- RNA regulation and disease
- Transition Metal Oxide Nanomaterials
- Carbon Nanotubes in Composites
- Copper Interconnects and Reliability
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Cytomegalovirus and herpesvirus research
- Advanced Photocatalysis Techniques
- interferon and immune responses
- Muscle Physiology and Disorders
- SARS-CoV-2 and COVID-19 Research
- RNA Interference and Gene Delivery
- Effects of Radiation Exposure
Yonsei University
2025
Brown University
2021-2025
John Brown University
2024
Chung-Ang University
2020-2022
Seoul National University
1998-2022
Institute for Basic Science
2018-2022
Xi'an Jiaotong University
2022
Hanyang University
2013-2019
Ansan University
2015-2017
Government of the Republic of Korea
2017
A tale of not-so-pure tails The poly(A) tail mRNA has been thought to be a pure stretch adenosine nucleotides with little informational content except for length. Lim et al. identified enzymes that can decorate non-A nucleotides. noncanonical polymerases, TENT4A and TENT4B, incorporate intermittent residues (G, U, or C) preference guanosine, which results in heterogenous tail. Deadenylases trim initiate degradation but stall at the residues. In effect, stabilizes mRNAs by slowing down...
The long-term steady production of H2 is vital for p-Si photocathodes. However, the oxidation a Si photoelectrode substantially deteriorates its performance, over time. This study demonstrates that thin Al2O3 layer deposited can prevent and also reduce overpotential, via surface passivation effect.
The design of flexible and durable bifunctional oxygen electrocatalysts is indispensable for rechargeable metal–air batteries.
Plasma membrane rupture by Ninjurin-1 (NINJ1) executes programmed cell death, releasing large cellular damage-associated molecular patterns (DAMPs). However, the regulation and selectivity of NINJ1-mediated DAMP release remain unexplored. Here, we uncover that murine norovirus (MNoV) strategically co-opts NINJ1 to selectively intracellular viral protein NS1, while plasma simultaneously bulk-releases various DAMPs. Host caspase-3 cleaves precursor NS1/2, leading NS1 secretion via an...
Endotoxemia, a type of sepsis caused by gram-negative bacterial endotoxin [i.e., lipopolysaccharide (LPS)], is associated with manifestations such as cytokine storm; failure multiple organs, including the liver; and high mortality rate. We investigated effect mechanism action LGK974, Wnt signaling inhibitor, in mice LPS-induced endotoxemia, an animal model sepsis. LGK974 significantly dose-dependently increased survival rate reduced plasma levels endotoxemia. Transcriptome analysis liver...
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is mediated by the entry receptor angiotensin-converting enzyme (ACE2). Although attachment factors and coreceptors facilitating are extensively studied, cellular inhibiting viral largely unknown. Using a surface ome CRISPR activation screen, we identified human LRRC15 as an inhibitory factor for SARS-CoV-2 entry. directly binds to receptor-binding domain (RBD) of spike protein with moderate affinity inhibits...
Murine norovirus (MNoV) is a model for human and interrogating mechanisms of viral tropism persistence. We previously demonstrated that the persistent strain MNoVCR6 infects tuft cells, which are dispensable non-persistent MNoVCW3. now show diverse MNoV strains require cells chronic enteric infection. also demonstrate interferon-λ (IFN-λ) acts directly on to cure infection type I III IFNs signal together via STAT1 in restrict MNoVCW3 tropism. then develop an enteroid find similarly infect...
Identifying receptors for bat coronaviruses is critical spillover risk assessment, countermeasure development, and pandemic preparedness. While Middle East respiratory syndrome coronavirus (MERS-CoV) uses DPP4 entry, the of many MERS-related betacoronaviruses remain unknown. The merbecovirus HKU5 was previously shown to have an entry restriction in human cells. Using both pseudotyped full-length virus, we show that Pipistrellus abramus ACE2 but not or as a receptor. Cryo-electron microscopy...
ZnO nanoparticles were grown on single-walled carbon nanotubes (SWNTs) by atomic layer deposition using diethylzinc (DEZ) and water. The athors discuss that, because of chemical inertness to DEZ water molecules, such are not likely grow the wall clean perfect nanotubes. Rather, growth should be attributed imperfection nanotubes, as defects carbonaceous impurities. Lifetime field emission from SWNTs with is 2.5 times longer than that as-grown It thought protection or impurities mainly...
The electronic structure of amorphous ZnO film (a-ZnO) was examined by O K- and Zn L3-edge x-ray absorption spectroscopy valence band photoemission spectroscopy. Comparative studies a-ZnO a wurtzite (w-ZnO) revealed decrease in 4s-O 2p hybridization strength the localization 4s as consequence local structural disorder, indicating limited electron hopping interactions a-ZnO. 0.1 eV higher Fermi-level compared to w-ZnO suggests that electrical properties are different from those due even...
Hybrid organic-inorganic photovoltaic devices consisting of poly(3,4-etyhlenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) and n-type silicon have recently been investigated for their cost-efficiency ease fabrication. We demonstrate that the insertion an ultrathin Al2O3 layer between n-Si PEDOT:PSS significantly improves performance in comparison to conventional interfacial oxide employing SiO2. A power-conversion efficiency 11.46% was recorded at optimal thickness 2.3 nm. This result...
Abstract Small, compact genomes confer a selective advantage to viruses, yet human cytomegalovirus (HCMV) expresses the long non-coding RNAs (lncRNAs); RNA1.2, RNA2.7, RNA4.9, and RNA5.0. Little is known about function of these lncRNAs in virus life cycle. Here, we dissected functional molecular landscape HCMV lncRNAs. We found that occupy ~ 30% 50–60% total poly(A)+viral transcriptome, respectively, throughout three abundantly expressed lncRNAs, appear be essential all infection states....
This study examined the influence of postdeposition annealing on composition and local structures amorphous In–Ga–Zn–O (IGZO) thin films using X-ray photoemission/absorption spectroscopy diffraction. Upon at high temperatures in an environment, Zn content a-IGZO decreased significantly, suggesting ZnO volatilization. The resultant crystallization IGZO was also observed. However, bipyramidal Ga ions were still preserved, even after , indicating replacement with without altering hexagonal...
Herein, we present a facile and simple strategy for in situ synthesis of functionalized carbon nanoparticles (CNPs) via direct pyrolysis ethylenediaminetetraacetic acid (EDTA) on silicon surface. The CNPs were incorporated hybrid planar n-Si poly(3,4-etyhlenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) solar cells to improve device performance. We demonstrate that the CNPs-incorporated devices showed increased electrical conductivity (reduced series resistance) minority carrier...
RNA represents a pivotal component of host–pathogen interactions. Human cytomegalovirus (HCMV) infection causes extensive alteration in host metabolism, but the functional relationship between virus and cellular processing remains largely unknown. Through loss-of-function screening, we show that HCMV requires multiple RNA-processing machineries for efficient viral lytic production. In particular, RNA-binding protein Roquin, whose expression is actively stimulated by HCMV, plays an essential...
We demonstrated surface passivation of a black Si-based solar cell using an (NH4)2S solution to mitigate recombination velocity. Incorporated S at the interface between atomic-layer-deposited Al2O3 and Si by treatment boosted density negative fixed charges, S-enhanced field-effect passivation. Furthermore, NH4OH generated during removed defective phase surface, cleaning effect. The optimized significantly enhanced internal quantum efficiency up ∼17.2% in short wavelength region, suggesting...
The degradation mechanism of Al2O3 passivation on nanostructured Si is resolved by separate considerations interface state density and fixed charge at the Al2O3/Si. Using analysis surface potentials, it reported for first time that positive charges seriously deteriorate field-effect a surface.
ABSTRACT SARS-CoV-2 infection is mediated by the entry receptor ACE2. Although attachment factors and co-receptors facilitating are extensively studied, cellular inhibiting viral largely unknown. Using a surface ome CRISPR activation screen, we identified human LRRC15 as an inhibitory for entry. directly binds to receptor-binding domain (RBD) of spike protein with moderate affinity inhibits spike-mediated Analysis lung single cell RNA sequencing dataset reveals that expression primarily...