A5063693245- Bacteriophages and microbial interactions
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Viral Infections and Outbreaks Research
- Plant Virus Research Studies
- Bat Biology and Ecology Studies
- Viral Infections and Vectors
- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Microbial Natural Products and Biosynthesis
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Virology and Viral Diseases
- COVID-19 epidemiological studies
- Plant Pathogens and Fungal Diseases
- Microbial Community Ecology and Physiology
- Plant and Fungal Interactions Research
- Bacterial Infections and Vaccines
University of Pennsylvania
2021-2024
Yale University
2024
Children's Hospital of Philadelphia
2021
Woods Hole Oceanographic Institution
2021
Identifying receptors for bat coronaviruses is critical spillover risk assessment, countermeasure development, and pandemic preparedness. While Middle East respiratory syndrome coronavirus (MERS-CoV) uses DPP4 entry, the of many MERS-related betacoronaviruses remain unknown. The merbecovirus HKU5 was previously shown to have an entry restriction in human cells. Using both pseudotyped full-length virus, we show that Pipistrellus abramus ACE2 but not or as a receptor. Cryo-electron microscopy...
In the course of studying virome protozoan parasites, we identified small circular genomes resembling viruses, which turned out to be contaminants from an RNA purification kit. We report their sequences here so others can detect possible contamination in samples by aligning them these targets.
ABSTRACT Relatively little is known about the diversity of fungi in deep-sea, hydrothermal sediments. Less thoroughly explored environments are likely untapped reservoirs unique biodiversity with potential to augment our current arsenal microbial compounds biomedical and/or industrial applications. In this study, we applied traditional culture-based methods examine a subset morphological and phylogenetic filamentous yeasts present 11 hydrothermally influenced sediment samples collected from...
We report the genome of a circular Rep-encoding segmented or satellite virus, which we have provisionally named rengasvirus. In metagenomic studies virus-enriched fractions, rengasvirus was detected widely, including in reagent-negative controls. thus this to help others recognize probable contaminating sequence.
Sarcoidosis is a multisystem granulomatous inflammatory disease of unclear etiology that involves the lung, skin and other organs, with an unknown antigenic trigger. Recently, evidence has been found in both immune deficient competent patients for rubella virus cutaneous granulomas. These lesions share overlapping features sarcoidosis, raising question sarcoidosis.To investigate presence sarcoidosis lung samples.We employed metagenomic sequencing to interrogate extracellular virome...
Abstract Background Amoxicillin 90 mg/kg/day divided twice daily is recommended for children with mild community acquired pneumonia (CAP). While adequate fully susceptible Streptococcus pneumoniae isolates, three times dosing allows achievement of greater amoxicillin exposure, which may be necessary isolates penicillin minimum inhibitory concentrations (MIC) ≥ 2 μg/mL. We evaluated our current strategy by characterizing 1) the MIC distribution among S. and 2) frequency clinical treatment...