A5041927706- Circular RNAs in diseases
- Analytical Methods in Pharmaceuticals
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Rheumatoid Arthritis Research and Therapies
- Advanced Thermoelectric Materials and Devices
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Plant-based Medicinal Research
- RNA modifications and cancer
- Systemic Lupus Erythematosus Research
- Thermal properties of materials
- Analytical Chemistry and Chromatography
- Bone Tumor Diagnosis and Treatments
- Retinopathy of Prematurity Studies
- Osteoarthritis Treatment and Mechanisms
- Ginseng Biological Effects and Applications
- Histone Deacetylase Inhibitors Research
- Inflammatory mediators and NSAID effects
- Moyamoya disease diagnosis and treatment
- Neonatal Respiratory Health Research
- Total Knee Arthroplasty Outcomes
- Sarcoma Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Orthopedic Surgery and Rehabilitation
Kyungpook National University
2007-2025
Gachon University
2024
Inha University Hospital
2024
Inha University
2024
Chonnam National University
2019-2021
Chonnam National University Hwasun Hospital
2019-2020
Massachusetts General Hospital
1982-2018
Surugadai Nihon University Hospital
2018
Kyung Hee University
2007-2016
Nihon University
1997-2014
<h3>Objectives:</h3> A large-scale postmarketing surveillance (PMS) study was carried out to determine the safety profile of infliximab in Japanese patients with rheumatoid arthritis (RA). <h3>Methods:</h3> The PMS performed for all RA who were treated infliximab. They consecutively registered at initiation treatment and prospectively monitored adverse events noted a period 6 months. All case reports, which include safety-related events, collected monthly. <h3>Results:</h3> Adverse drug...
An interim analysis of an all-patient postmarketing surveillance programme in Japan to investigate the safety tocilizumab for treatment rheumatoid arthritis (RA) real world.This included 3881 patients. Patients received 8 mg/kg every 4 weeks, and were observed 28 weeks. Data on baseline characteristics adverse events (AE) collected.Total serious AE reported as 167 27 events/100 patient-years, respectively. The most frequent infections. Logistic regression identified following risk factors...
Exosomes are extracellular vesicles that can contain DNA, RNA, proteins, and metabolites. They secreted by cells play a regulatory role in various biological responses mediating cell-to-cell communication. Moreover, exosomes of interest developing therapies for retinal vascular disorders because they deliver substances to cellular targets. According recent research, be used as strategy managing diseases, being investigated therapeutic purposes eye conditions, including glaucoma, dry...
Heart failure is a leading cause of death and often accompanied by activation quiescent cardiac myofibroblasts, which results in fibrosis. In this study, we aimed to identify novel circular RNAs that regulate We applied transverse aortic constriction (TAC) for 1, 4, 8 weeks mice. RNA sequencing datasets were obtained from fibroblasts isolated use Langendorff apparatus then further processed selection criteria such as differential expression conservation species. CircSMAD4 was upregulated TAC...
Circular RNAs (circRNAs) are generally formed by back splicing and expressed in various cells. Vascular calcification (VC), a common complication of chronic kidney disease (CKD), is often associated with cardiovascular disease. The relationship between circRNAs VC has not yet been studied. Inorganic phosphate (Pi) was used to treat rat vascular smooth muscle cells induce VC. were identified analyzing RNA sequencing (RNA-seq) data, their expression change during validated. selected circRNAs,...
Vascular calcification, the ectopic deposition of calcium in blood vessels, develops association with various metabolic diseases and atherosclerosis is an independent predictor morbidity mortality associated these diseases. Herein, we report that reduction microRNA-27a-3p (miR-27a-3p) causes increase activating transcription factor 3 (ATF3), a novel osteogenic factor, vascular smooth muscle cells. Both microRNA (miRNA) mRNA microarrays were performed rat cells, reciprocally regulated pairs...
Individuals with latent tuberculosis infection (LTBI) are at risk of progressing to active (TB), which remains a significant cause death globally. Although various antiTB medications—rifampin and isoniazid—exist for treating both LTBI TB, pharmacovigilance studies evaluating their adverse effects especially scare LTBI. Given the continued status South Korea as having highest TB incidence among Organization Economic Cooperation Development countries, this study examines drug-related events...
To evaluate the pharmacokinetics of compound K after oral administration HYFRG and RG in humans, an open‐label, randomized, single‐dose, fasting, one‐period pharmacokinetic study was conducted. After a single 3 g dose to 24 healthy Korean males, mean (±SD) AUC 0– t C max from were 1466.83 ± 295.89 ng·h/mL 254.45 51.20 ng/mL, being 115.2‐ 80‐fold higher than those for (12.73 7.83 3.18 1.70 ng/mL), respectively; case Sprague Dawley rats 58.03 32.53 15.19 10.69 6.3‐ 6.0‐fold (9.21 7.52 2.55...
Abstract Vascular calcification is characterized by the accumulation of hydroxyapatite crystals, which a result aberrant mineral metabolism. Although many clinical studies have reported its adverse effects on cardiovascular morbidity, molecular mechanism vascular calcification, especially involvement long noncoding RNAs (lncRNAs), not yet reported. From transcriptomic analysis, we discovered hundreds lncRNAs differentially expressed in rat smooth muscle cells (VSMCs) treated with inorganic...
Vascular calcification (VC), or calcium deposition inside the blood vessels, is common in patients with atherosclerosis, cardiovascular disease, and chronic kidney disease. Although several treatments are available to reduce calcification, incidence of VC continues rise. Recently, there have been reports describing regulation circular RNAs (circRNAs) various diseases. However, role circRNAs has not yet fully explored. Here, we investigated function circSmoc1-2, one generated from Smoc1 gene,...
The cases histories of 51 rheumatoid arthritis patients (58 hands) were examined retrospectively with respect to the incidence tendon rupture. Factors that associated rupture such as X-ray changes in wrist joint and clinical findings hand preceding statistically analysed. In a separate study, prophylactic tenosynovectomy synovectomy performed on 42 joints 35 who had two or more risk factors. This group was then analysed for subsequent recurrent synovitis. factors extensor dorsal found be:...
The function of Epstein–Barr virus (EBV)-specific cytotoxic T cells is disturbed in rheumatoid arthritis (RA) patients but the mechanism for this disturbance has remained unknown. In a recent study searching causative gene X-linked lymphoproliferative syndrome, possibly linked to EBV-specific or NK cell-mediated activity EBV-infected was discovered, and its product now referred as signaling lymphocytic-activation molecule-associated protein (SAP) Src homology 2 domain-containing (SH2D1A)....
Long noncoding RNAs (lncRNAs) have recently been implicated in many pathophysiological cardiovascular processes, including vascular remodeling and atherosclerosis. However, the functional role of lncRNAs differentiation, proliferation, apoptosis smooth muscle cells (VSMCs) is largely unknown. In this study, differentially expressed synthetic contractile human VSMCs were screened using RNA sequencing. Among seven selected lncRNAs, expression MSC-AS1, MBNL1-AS1, GAS6-AS2 was upregulated,...
In order to improve the performance of thermoelectric materials, nanoinclusions are often used enhance phonon scattering. this study, activated carbon, which is porous and thus has a large surface area, was incorporated in GeTe-based materials cause increased boundary Carbon dispersed grain boundaries resulted improved thermal properties without significant deterioration electrical properties. Due extrinsic addition lattice conductivity decreased by 13.8% on average. A maximum dimensionless...
Abstract Metabolic syndromes, including obesity, cause neuropathophysiological changes in the brain, resulting cognitive deficits. Only a few studies explored contribution of non-coding genes these pathophysiologies. Recently, we identified obesity-linked circular RNAs (circRNA) by analyzing brain cortices high-fat-fed obese mice. In this study, scrutinized conserved and neuron-specific circRNA, circTshz2-2, which affects neuronal cell cycle spatial memory brain. Transcriptomic cellular...
Purpose. Giant cell tumour of bone with pulmonary metastases is rare. However, some patients die metastases, and histological examination cannot distinguish between benign malignant metastases. In this study, we present clinical immunohistochemical findings associated giant Methods. Five (one man 4 women) were studied. Patients' ages ranged 20 23 years (mean age, 21.8 years). Tumours in the distal femur 2 cases, proximal tibia, lumbar spine one case each. The tissue specimens from primary...
EphA3 is a component of the Eph/ephrin tyrosine kinase system, which participates in vasculature development. This receptor/ligand system associated with various signaling pathways related to cell growth and viability, cytoskeletal organization, migration, anti-apoptosis. Accumulated evidence suggests that aberrant regulation its genetic alterations are implicated development progression cancers. However, despite high incidence over-expression, no such investigation has been performed...