A5044477620- Pituitary Gland Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Photosynthetic Processes and Mechanisms
- Plant Stress Responses and Tolerance
- Ophthalmology and Eye Disorders
- CRISPR and Genetic Engineering
- Plant tissue culture and regeneration
- Adrenal and Paraganglionic Tumors
- Transgenic Plants and Applications
- Plant nutrient uptake and metabolism
- Diabetes Management and Research
- Diabetes Treatment and Management
- Infective Endocarditis Diagnosis and Management
- Plant Taxonomy and Phylogenetics
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Glioma Diagnosis and Treatment
- Plant Molecular Biology Research
- Growth Hormone and Insulin-like Growth Factors
- Glaucoma and retinal disorders
- Thyroid Disorders and Treatments
- Viral gastroenteritis research and epidemiology
- CNS Lymphoma Diagnosis and Treatment
- Microscopic Colitis
- Minimally Invasive Surgical Techniques
- BRCA gene mutations in cancer
Yonsei University
2014-2024
Yonsei University Health System
2024
CHA University
2023
Chonnam National University
2012-2022
National Health Insurance Service
2018-2021
National Health Insurance Service Ilsan Hospital
2018-2021
Andong National University
2021
Hallym University Kangnam Sacred Heart Hospital
2018
Korea University
2014
Sex and age are factors conferring resistance to medical treatment in patients with acromegaly. However, their impact on outcomes of transsphenoidal-selective adenomectomy (TSA) has not been evaluated. To analyze age- sex-related differences concerning surgical growth hormone (GH)-secreting pituitary adenomas. Retrospective. Single-center tertiary hospital. Patients acromegaly (n = 463) who underwent TSA between January 2000 July 2014. TSA. Tumor characteristics outcomes. existed the...
Abstract Understanding how comorbidities contribute to death in cancer patients is becoming an important topic. The present study assessed the role of overall mortality and causes with differentiated thyroid carcinoma (DTC). This retrospective cohort included 2070 who underwent thyroidectomy for DTC at a single institution between 2002 2005. Probabilities overall, DTC-specific other-cause were examined according number comorbidities, consideration competing events. estimated 15-year...
Ascorbate is an essential antioxidant substance for humans. Due to the lack of ascorbate biosynthetic enzyme, a human must intake from food source. Tomato one most widely consumed fruits, thus elevation content in tomato fruits will improve their nutritional value. Here we characterized Solanum lycopersicum ASCORBATE PEROXIDASE 4 (SlAPX4) as gene specifically induced during fruit ripening. In tomatoes, accumulates yellow stage then decreases later stages To investigate whether SlAPX involved...
Graves' disease (GD) is an autoimmune disorder that causes the overproduction of thyroid hormones and consequent cascade systemic metabolism dysfunction. Moreover, ophthalmopathy (GO) main extrathyroidal manifestation (GD). The goal study was to identify metabolic signatures in association with diagnostic biomarkers GD without GO GO, respectively. Ninety metabolites were profiled analyzed based on a non-targeted primary metabolite profiling from plasma samples 21 patients 26 subjects 32...
Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), produced by intestinal enteroendocrine L cells, are important gut hormones that coordinate gastrointestinal physiology, metabolism, appetite. We aimed to investigate the role of olfactory receptor (OR) OR51E1 in GLP-1 PYY secretion. analyzed expression marker protein (OMP), an indicator OR-mediated events nonolfactory systems, human cells. Furthermore, we OMP cell line NCI-H716. To whether odorant-activated OR signaling stimulates...
Abstract Background There are many non-cereal monocots of agronomic, horticultural, and biofuel importance. Successful transformation these species requires an understanding factors controlling expression their genes. Introns have been known to affect both the level tissue-specific genes in dicots cereal monocots, but there no studies on intron isolated from a monocot. This study characterizes levels GUS uidA mRNA that code for β-glucuronidase (GUS) leaves Gladiolus Arabidopsis using GUBQ1 ,...
Because of the development new classes antidiabetic drugs, hypoglycemic events were expected to decrease. We investigated trends and risk factors for severe hypoglycemia in subjects with type 2 diabetes Korea.We conducted repeated cross-sectional analyses using a Korean National Health Insurance Service-National Sample Cohort from 2006 2015. Severe was defined as hospitalization or visit an emergency department diagnosis ICD-10 codes.During study period, prevalence continuously increased....
Abscisic acid (ABA) is a key signaling molecule that mediates plant response to stress. Increasing evidence indicates ABA also regulates many aspects of development, such as seed germination, leaf and ripening. metabolism, including biosynthesis degradation, an essential aspect in plants. In this study, we identified four cytochrome P450 genes ( CaCYP707A1 , 2 3 4 ) mediate hydroxylation, which required for degradation Capsicum annuum . We observed CaCYP707A-mediated hydroxylation promotes...
Metabolic impairment is the common cause for mortality in acromegalic patients. In this study, long-term improvements of metabolic parameters were evaluated according to 2 different remission criteria.This was an observational cohort study before and up 1 year after transsphenoidal adenomectomy (TSA). Participants 187 patients with acromegaly. At 6 months TSA, remitted age- sex-matched normalized IGF-1 divided into groups: (R1), nadir growth hormone (GH) below 0.4 ng/mL; (R2), GH between 1.0...
We report a method to precisely quantify dielectrophoretic (DEP) forces and cutoff frequencies (fc) of viable nonviable yeast cells. The consists two-step process in which generated DEP act upon cell through micro-electrode device, followed by direct measurement using optical tweezers. behaviors cells are monitored as function AC frequency. believe that the proposed can be used powerful platform for cell-based assays characterize behavior various types including cancer normal
Hyperglycemia is associated with increased mortality and morbidity in patients type 2 diabetes mellitus (T2DM) who are undergoing dialysis. Although dipeptidyl peptidase-4 (DPP-4) inhibitors have been widely used end-stage renal disease (ESRD) T2DM, there few studies on their efficacy this population. We studied the effect of 3 different DPP-4 metabolic parameters ESRD T2DM. Two hundred T2DM were treated (sitagliptin, vildagliptin, or linagliptin) enrolled analyzed retrospectively. The...
Abstract Background Diffuse lymphocytic infiltration (DLI) is frequently found with papillary thyroid cancer (PTC), so there has been long interest in how it affects the characteristics of PTC. This purpose this study was to define association between DLI and PTC aggressiveness according thyroperoxidase antibody (TPOAb) B‐type Raf (BRAF) V600E mutation positivity. Methods There were 1879 patients who underwent surgery enrolled study. Clinicopathologic compared groups presence TPOAb. Multiple...
Background: Hyperglycemic crisis is a metabolic emergency associated with diabetes mellitus.However, accurate epidemiologic information on cases of hyperglycemic in Korea remains scarce.We evaluated trends hospitalizations and in-and out-of-hospital mortality Korea.We also predicted future trends.Methods: We extracted claims data as the principal diagnosis from National Health Insurance Service database January 2004 to December 2013.We investigated numbers identified based those data.We by...
Abstract The production of pharmacological vaccines in plants has been an important goal the field plant biotechnology. GA733-2, protein that is also known as colorectal carcinoma (CRC)-associated antigen, a strong candidate to produce cancer vaccine. Tomato one major targets for edible vaccine, tomato fruit consumed fresh form. It contains high content vitamins aid activation immune response. In order develop transgene rGA733-Fc encodes fusion fragment crystallizable (Fc) domain, and ER...
Systemic vascular dysfunction has been suggested to contribute glaucomatous damage. Albuminuria is a surrogate marker of endothelial injury, including vessels. However, their relationship not well understood. This study aimed investigate the association between albuminuria and prevalence open-angle glaucoma (OAG) in nondiabetic subjects.We conducted cross-sectional 4186 participants aged 19 years or older from 2011-2012 Korea National Health Nutrition Examination Survey. OAG was defined...
GA733-2, an epithelial cell adhesion molecule highly expressed at the human colorectal carcinoma surface, is a candidate protein for development of cancer preventive vaccine. In this study, signal peptide and c-terminal transmembrane domain truncated GA733-2 was fused to His-tag, recombinant (rGA733-2) in Escherichia coli Rosetta (DE3) pLysS. rGA733-2 form inclusion bodies, purified using either serial dialyzed urea refolding method or metal ion exchange column after 8 M solubilization. The...
The incidence of Clostridium difficile infection is increasing worldwide, and its severity resulting mortality are also on the rise. Metronidazole oral vancomycin remain treatments choice, but there concerns about treatment failure appearance resistant strains. Furthermore, antibiotic therapy results in recurrence rates at least 20%. Fecal transplantation may be a feasible option for recurrent C. infection; moreover, it an early severe infection. We report case treated with fecal using...
Radioactive iodine (RAI) therapy is an effective treatment option for Graves’ disease. However, predicting failures after RAI remains controversial. The objective of this study was to investigate the factors associated with success rate hyperthyroidism. Thyroid functional outcome, pre-RAI ultrasonographic features, and clinical parameters were evaluated retrospectively in 98 patients followed up at least 12 months (mean dose 11.7 ± 1.8 mCi). Hypothyroidism achieved 59 (60.2%), euthyroidism...