OBJECTIVE: To determine the immunologic effects of oropharyngeal colostrum administration in extremely premature infants. METHODS: We conducted a double-blind, randomized, placebo-controlled trial involving 48 preterm infants born before 28 weeks’ gestation. Subjects received 0.2 mL their mother’s or sterile water via route every 3 hours for days beginning at to 96 life. measure concentrations secretory immunoglobulin A, lactoferrin, and several immune substances, urine saliva were obtained...

<b><i>Background:</i></b> White matter injury (WMI) is the most common form of brain in preterm infants. It could be induced by a systemic inflammatory response <b><i>Objectives:</i></b> We hypothesized that surgical necrotizing enterocolitis (surgNEC) results more severe WMI than spontaneous intestinal perforation (SIP) on magnetic resonance imaging (MRI) at term-equivalent age (TEA). <b><i>Methods:</i></b> The medical...

<title>Abstract</title> We hypothesized that incorporating postnatal dynamic factors would enhance the prediction accuracy of bronchopulmonary dysplasia in preterm infants. This retrospective cohort study included neonates born before 32 weeks gestation at Seoul National University Hospital between 2013 and 2022. The primary outcome was moderate or severe dysplasia. assessed both static perinatal risk factors, such as respiratory support type, inspired oxygen concentration, blood gas...

For premature infants with advanced acute abdomen, creating a temporary enterostomy is believed to be an appropriate surgical management. However, there no consensus regarding the timing of reversal. The aim this study was determine optimal for closure (EC) by analyzing EC-related complications.This retrospective preterm who underwent suspected abdomens and subsequent closure.EC-related complications occurred in 35 54 (65%). A univariate analysis determined following risk factors...

To evaluate clinical applicability of noninvasive hemoglobin (Hb) measurement with a pulse CO-oximeter in neonates.Prospective comparison study.Neonatal ICU.Fifty-six preterm and term infants median age = 20 days (range 1-98 days) weight 1,440 g 530-4,230 g).Hb measurements by Pulse CO-Oximetry (Masimo Radical-7) were recorded immediately prior to venous samplings.The collected data compared the corresponding Hb level obtained laboratory testing, total 137 pairs analyzed. Noninvasive values...

Increased survival in the very preterm population results a higher risk of developing neurodevelopmental and behavioral disabilities among survivors. We examined outcomes infants parents after preventive intervention program four home visits by specialized nurse, 5 days, 2 weeks, 1 month discharge, respectively, at CA months, followed up to 12 times group sessions between 3 6 months. Our multicenter randomized controlled trial assessed 138 (gestational age ≤30 weeks or birth weight ≤1500 g)...

Although impaired neurodevelopment is strongly associated with severe brain injury, most preterm infants survive without injury. In this study, the association of and neonatal morbidities was assessed after excluding those This a retrospective study very low birthweight in single tertiary center. After population categorized as intraventricular hemorrhage (IVH) low-grade IVH. Neurodevelopmental outcomes at corrected age (CA) 18–24 months were evaluated using Bayley Scales Infant Toddler...

Spontaneous intestinal perforation (SIP) and surgical necrotizing enterocolitis (NEC) are conditions requiring intervention in preterm infants. We aimed to compare the head growth neurodevelopment of infants with SIP NEC. A retrospective single-center study was performed born at less than 32 weeks gestation who had undergone surgery for NEC or SIP. Data from Bayley Scales Infant Toddler Development 3rd Edition (Bayley-III) 24 months corrected age (CA) Korean Ages Stages Questionnaire (K-ASQ)...

Abstract Background Pulmonary hypertension (PH) is a life-threatening condition in newborns. We aimed to assess the clinical and echocardiographic responses of term preterm infants treprostinil. Methods This retrospective study included newborns diagnosed with PH treated treprostinil as additional therapy after inhaled nitric oxide administration neonatal intensive care unit tertiary center. Term were compared terms findings 4 weeks treatment. Results During period, 11 18 received There no...

Geiger-mode avalanche photodiode (GAPD) has been demonstrated to be a high performance PET sensor because of gain, fast response, low excess noise, bias voltage operation and magnetic field insensitivity. The purpose this study is develop for human brain imaging using 4 × array large size GAPD. detector modules were designed built prototype PET. consisted 72 arranged in ring with an inner diameter 330 mm. LYSO arrays 3 20 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...

Purpose: This study aimed to investigate the influence of routine probiotic supple mentation on causes neonatal morbidity and mortality, such as necrotizing en terocolitis (NEC) late onset sepsis.Methods: All neonates born at <32 weeks gestation weighing <1,500 g admitt ed intensive care unit during period were included.The was divided into preprobiotic period, between January 2009 February 2011, November 2012 Decem ber 2014.The given a mixture Lactobacillus plantarum, L. rhamno sus,...

Purpose:The survival rate of infants weighing less than 1,000 g at birth(extremely low birth weight infants, ELBWI) has increased due to recent advances in perinatal and neonatal intensive care. The purpose this study was evaluate the rates ELBWI born Seoul National University Hospital during last six years. Methods:A total 99 were divided into three groups(period Ⅰ:2000 2001, period Ⅱ: 2002 2003, Ⅲ:2004 2005) based on date birth. We compared over periods, using CRIB Ⅱ score for adjustment...

The purpose of this study is cross-compatibility PET and MRI was characterized to explore the optimal method overcoming possible interferences between them. MR phantom images were acquired by placing components inside outside RF-coil in 7-T examine effect relative position detector on MRI. Theoretical evaluation shielding effectiveness (SE) plate mesh Cu calculated characterize criteria for reducing mutual interference Experimental studies performed that image quality as a function area...

The aim of this study is to develop a MR compatible PET that insertable MRI and allows simultaneous imaging human brain. brain having 72 detector modules arranged in ring 330 mm diameter was designed. Each module composed 4 ? matrix 3 20 LYSO crystals coupled tileable array Geigermode avalanche photodiode (GAPD) designed locate between RF gradient coils. Signals the each were transferred preamplifiers using flexible flat cable m long, then sent position decoder circuit (PDC), which outputs...

BackgroundThe study aimed to identify factors associated with compliance follow-up (FU) appointments among infants following their discharge from the neonatal intensive care unit (NICU).MethodsThis retrospective cohort reviewed 657 (birth weight <1500 g or gestational age [GA] <32 weeks), born between 2011 and 2015. A total of 525 eligible were classified into two groups: compliant group (n = 360), who attended clinics 18 24 months, non-compliant 165), lost FU before months.ResultsThe was...

A Geiger-mode avalanche photodiode (GAPD) array-based MRI compatible PET is being developed in our laboratory. The purpose of this study to develop filtering methods for event signals contaminated by RF pulses simultaneous PET-MR imaging. detector the was composed LYSO scintillators coupled with GAPD arrays. signal acquisition implemented a FPGA-based data (DAQ) system. noise caused field has large effect on when detectors are placed inside MRI. In study, software, hardware and hybrid were...

A simple and improved digital timing method has been developed for positron emission tomography (PET). The so-called initial rise interpolation is based on an important characteristic of gamma signal: a properly pre-amplified sampled signal pulse can be characterized to arrive with from baseline then go up maximum rise. Pulse arrival time obtained by calculating the intersection line each pulse. In this study, FPGA-based data acquisition (DAQ) card was used processing. We measured...

Our prior findings showed that BCL2A1 in neutrophils is highly expressed the extra-placental membranes (EPMs) of both human spontaneous preterm-birth (PTB) (i.e., PTL or preterm PROM) and nonhuman-primate PTB model. However, no data exist on whether intensity expression quantitatively increases according to stage progression acute histologic chorioamnionitis (acute HCA) EPM. The objective investigate HCA EPM among cases, as measured using QuPath. study population included 121 singleton PTBs...

We evaluated frequency and risk factors of delayed TSH elevation (dTSH) investigated follow-up outcomes in the dTSH group with venous (v-TSH) levels 6-20 mU/L according to whether late preterm infants born at gestational age (GA) 35-36 weeks had factors.The medical records 810 neonates (414 boys) Seoul National University Hospital who a normal neonatal screening test (NST) underwent first repeat blood 10-21 days post birth were reviewed.Seventy-three (9.0%) showed dTSH, defined as v-TSH...

In this study, we were the development and calibration of new complex sensor which is similar to tactile sensing human due can be measured normal shear force by using newly developed synthetic elastomer conductive silicone. The sense pressing capacitance changes as thickness applied in surface. And change an electrode area when force. CDC(capacitance digital converter integrated circuits) data transmitted user interface a Host PC though microcontroller system constructed for signal...

Probiotics are living micro-organisms that beneficially affect the composition of host intestinal microflora.In very preterm infants, probiotics reportedly help reduce necrotizing enterocolitis (NEC), invasive fugal colonization and sepsis, enable establishment complete enteral feeding at an earlier stage.However, emerging evidence has indicated risk potential side effects probiotic use, such as gut organism translocation, including organisms, in infants more premature.In present report, we...