A5110681667- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Reproductive tract infections research
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Urinary Tract Infections Management
- Protein Degradation and Inhibitors
- Antimicrobial Resistance in Staphylococcus
- Cancer Treatment and Pharmacology
- Acute Lymphoblastic Leukemia research
- Eosinophilic Disorders and Syndromes
- Bee Products Chemical Analysis
- Peptidase Inhibition and Analysis
- Immune Response and Inflammation
- Contact Dermatitis and Allergies
- Family and Disability Support Research
- Burn Injury Management and Outcomes
- Oral Health Pathology and Treatment
- Blood Pressure and Hypertension Studies
- HER2/EGFR in Cancer Research
- Streptococcal Infections and Treatments
- Dermatology and Skin Diseases
- Breast Lesions and Carcinomas
- Planetary Science and Exploration
Johnson University
2025
Rutgers, The State University of New Jersey
2025
Bristol-Myers Squibb (United States)
2014-2024
Creighton University
2014-2024
Drexel University
2020
Procter & Gamble (United States)
2005-2018
Bristol-Myers Squibb (Germany)
2003-2014
Health Economics and Outcomes Research (United Kingdom)
2011
Tufts Medical Center
2008-2011
Wilmington University
2011
Studies of the human microbiome have revealed that even healthy individuals differ remarkably in microbes occupy habitats such as gut, skin and vagina. Much this diversity remains unexplained, although diet, environment, host genetics early microbial exposure all been implicated. Accordingly, to characterize ecology human-associated communities, Human Microbiome Project has analysed largest cohort set distinct, clinically relevant body so far. We found abundance each habitat's signature vary...
The means by which vaginal microbiomes help prevent urogenital diseases in women and maintain health are poorly understood. To gain insight into this, the bacterial communities of 396 asymptomatic North American who represented four ethnic groups (white, black, Hispanic, Asian) were sampled species composition characterized pyrosequencing barcoded 16S rRNA genes. clustered five groups: dominated Lactobacillus iners, L. crispatus, gasseri , or jensenii whereas fifth had lower proportions...
A variety of microbial communities and their genes (the microbiome) exist throughout the human body, with fundamental roles in health disease. The National Institutes Health (NIH)-funded Human Microbiome Project Consortium has established a population-scale framework to develop metagenomic protocols, resulting broad range quality-controlled resources data including standardized methods for creating, processing interpreting distinct types high-throughput available scientific community. Here...
The normal microbial flora of the vagina plays an important role in preventing genital and urinary tract infections women. Thus accurate understanding composition ecology ecosystem is to aetiology these diseases. Common wisdom that lactobacilli dominate vaginal microflora post-pubertal However, this conclusion based on methods require cultivation populations; approach known yield a biased incomplete assessment community structure. In study cultivation-independent were used analyse samples...
To determine whether different racial groups shared common types of vaginal microbiota, we characterized the composition and structure bacterial communities in asymptomatic apparently healthy Japanese women Tokyo, Japan, compared them with those White Black from North America. The was based on community profiles terminal restriction fragments 16S rRNA genes phylogenetic analysis cloned gene sequences numerically dominant populations. found were similar to women. As women, most dominated by...
Abstract Background Microbial communities inhabiting human mouth are associated with oral health and disease. Previous studies have indicated the general prevalence of adult gingivitis in China to be high. The aim this study was characterize depth microbiota Chinese adults or without gingivitis, by defining microbial phylogenetic diversity community-structure using highly paralleled pyrosequencing. Methods Six non-smoking Chinese, three (age range 21-39 years, 4 females 2 males) were...
To our knowledge, no data are available on whether the microbial species composition and abundance sampled with self-collected vaginal swabs comparable to those of collected by clinicians. Twenty healthy women were recruited study during a routine gynecological visit. Eligible between 18 40 years old regular menstrual cycles. Participants swab using standardized protocol then examined physician, who an additional five from lateral wall mid-vagina. In this study, three physician-obtained...
Despite knowledge of the effects toxic shock syndrome (TSS) toxin 1 (TSST-1) on adaptive immune system, little is known about stimulation innate particularly epithelial cells. This study investigated interactions TSS Staphylococcus aureus and TSST-1 with human vaginal cells (HVECs) porcine mucosal surfaces. When cocultured HVECs for 6 h, S. MN8 proliferated, formed aggregates HVEC surfaces, produced exotoxins. Receptor binding studies showed that 35S-TSST-1 bound to 5 x 10(4) receptors per...
To examine components of family-centered care in families' stories about treatment decision making for their child with ADHD.Twenty-eight families participated qualitative interviews that addressed perspectives on (a) the decision-making process, (b) cause and impact child's symptoms, (c) goals preferences.The majority preferred to be primary or shared makers regarding decisions. Families' symptoms varied often were not consistent a biomedical framework. Families described multiple areas...
Culturing has detected vaginal Staphylococcus aureus in 10%-20% of women. Because growth mode can affect virulence expression, this study examined S. aureus-biofilm occurrence 44 paired-tampon and vaginal-wash-specimens from 18 prescreened women, using fluorescent situ hybridization (FISH). All specimens were also analyzed for by standard culturing on mannitol salt agar, which produced positive results 15 the specimens. FISH cells all specimens, biofilm was observed 37 Independent...
Abstract Background The availability of the tyrosine-kinase inhibitor (TKI), imatinib, and later introduction second generation TKIs, dasatinib nilotinib, have not only improved clinical outcomes patients with chronic myeloid leukemia (CML), but also provide multiple therapeutic options for CML patients. Despite widespread use these oral therapies, little is known about impact different treatment regimens on patient-reported (PROs) among objective this study was to assess restrictions...
Previous in vitro and vivo animal studies showed that O(2) CO(2) concentrations can affect virulence of pathogenic bacteria such as Staphylococcus aureus. The objective this work was to measure levels the vaginal environment during tampon wear using newly available sensor technology. Measurements by two sensors a decrease after insertion. These decreases were independent type tampons used time measurement (mid-cycle or menstruation). results are not agreement with previous study concluded...
ABSTRACT To define and monitor the structure of microbial communities found in human vagina, a cultivation-independent approach based on analyses terminal restriction fragment length polymorphisms (T-RFLP) 16S rRNA genes was developed validated. Sixteen bacterial strains commonly vagina were used to construct model that subsequently develop efficient means for isolation genomic DNA an optimal strategy T-RFLP analyses. The various genera community could best be resolved by digesting amplicons...
The objective of this study was to perform a preliminary characterization the microbial populations normal human vulva. Genomic DNA isolated from samples labia majora and minora four healthy women, sequences bacterial 16S rRNA genes in each were determined. compared with those known species classify numerically abundant these communities. Even among limited number individuals, microbiota vulva found be quite diverse. Each woman had distinctive no single common all women. differed, although...
Prior studies suggest Staphylococcus aureus exotoxins are not produced when the organism is cultured in human blood. Human blood was fractionated into plasma and water-lysed red cells, it demonstrated that mixtures of α β globins hemoglobin (as low as 1 μg/mL) inhibited S. exotoxin production while increasing protein A affecting bacterial growth. Pepsin but trypsin digestion destroyed ability globin to inhibit production. Exotoxin by both methicillin-resistant methicillin-susceptible...
Many cases of neonatal toxic shock syndrome (TSS)-like exanthematous disease but few menstrual TSS (mTSS) have been reported in Japan. We determined the prevalence mucosal colonization with Staphylococcus aureus and positive antibodies to toxin 1 (TSST-1) among 209 healthy Japanese women Tokyo. S. isolates from sites were characterized respect TSST-1 production resistance genotype. Antibody titers for test subjects 133 137 Caucasian control living United States. was isolated at least one...
Background: Composite outcome measures aim to provide a more holistic view when determining the effectiveness and safety of surgical interventions. Recently, ‘Ideal Outcome’ (IO) harmonized European American composite pancreatic surgery. The rate IO after pancreatoduodenectomy was 54% but is unknown left pancreatectomy(LP). Methods: This transatlantic analysis included patients LP from audits in North America (NSQIP), Germany (StuDoQ), Netherlands (DPCA), Sweden (SNPPCR) (2014 – 2020)....
Patient knowledge and awareness of hypertension are important factors in achieving blood pressure control. To examine hypertensive patients' their condition, the authors randomly surveyed 2500 patients from a large health maintenance organization; questionnaires were supplemented with clinic measurements. Approximately 72% subjects completed surveys. Of uncontrolled (systolic [SBP] 140 mm Hg and/or diastolic [DBP] 90 Hg), only 20.2% labeled as “high” 38.4% “borderline high.” Forty percent...