Valentina Serra
A5080987293- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Tryptophan and brain disorders
- Reproductive System and Pregnancy
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Biochemical effects in animals
- SARS-CoV-2 and COVID-19 Research
- Advanced Breast Cancer Therapies
- Neurotransmitter Receptor Influence on Behavior
- Renal Transplantation Outcomes and Treatments
- Ovarian cancer diagnosis and treatment
- Lung Cancer Research Studies
- Pregnancy and Medication Impact
- Transplantation: Methods and Outcomes
- Adolescent and Pediatric Healthcare
- Cardiovascular Disease and Adiposity
- Autoimmune and Inflammatory Disorders Research
- Multiple Sclerosis Research Studies
- Diabetes and associated disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Systemic Sclerosis and Related Diseases
- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
Institute of Genetic and Biomedical Research
2013-2025
National Research Council
2019-2025
University of Sassari
2013
Genomewide association studies of autoimmune diseases have mapped hundreds susceptibility regions in the genome. However, only for a few signals has causal gene been identified, and even fewer variant underlying mechanism defined. Coincident associations DNA variants affecting both risk disease quantitative immune variables provide an informative route to explore mechanisms drug-targetable pathways.Using case-control samples from Sardinia, Italy, we performed genomewide study multiple...
ABSTRACT The TYK2 :p.Pro1104Ala (rs34536443) hypomorph variant has been associated with protection against numerous autoimmune disorders. Thus, its mechanism of action becomes great interest. Here, consistent the participation activated immune cells in autoimmunity, we show that regulates levels at a human, general population level and is particularly higher T B lymphocytes, especially naïve (non‐activated) compartment. Also, protective function regulatory CD4+ was increased. this decreases...
Abstract In mice, the ability of naive T (TN) cells to mount an effector response correlates with TCR sensitivity for self-derived Ags, which can be quantified indirectly by measuring surface expression levels CD5. Equivalent findings have not been reported previously in humans. We identified two discrete subsets human CD8+ TN cells, defined absence or presence chemokine receptor CXCR3. The more abundant CXCR3+ cell subset displayed effector-like transcriptional profile and expressed TCRs...
Defective alleles within the PRF1 gene, encoding pore-forming protein perforin, in combination with environmental factors, cause familial type 2 hemophagocytic lymphohistiocytosis (FHL2), a rare, severe autosomal recessive childhood disorder characterized by massive release of cytokines-cytokine storm.The aim this study was to determine function hypomorph PRF1:p.A91V g.72360387 G > A on multiple sclerosis (MS) and 1 diabetes (T1D).We cross-compare association data for mutation derived from...
Fresh blood immunophenotyping by flow cytometry, based on the reliable simultaneous detection of several markers in a cell, is method choice to study circulating human immune system. Especially large and multicenter studies, high sample quality difficult achieve, adequate collection storage samples with fine-tuned whole cryopreservation mandatory. Here, we compared immunophenotypic data obtained from fresh those after five methods quantifying levels 41 cell populations. They comprised B T...
Disease-modifying therapies (DMTs) have been shown to improve disease outcomes in multiple sclerosis (MS) patients. They may also impair the immune response vaccines, including SARS-CoV-2 vaccine. However, available data on both intrinsic effects of DMTs and their influence cellular vaccine are still incomplete.
Abstract Rationale The use of synthetic cannabinoid receptor agonists (SCRAs) is growing among adolescents, posing major medical and psychiatric risks. JWH-018 represents the reference compound SCRA-containing products. Objectives This study was performed to evaluate enduring consequences adolescent voluntary consumption JWH-018. Methods reinforcing properties were characterized in male CD1 mice by intravenous self-administration (IVSA). Afterwards, behavioral, neurochemical, molecular...
The use of cryopreserved peripheral blood mononuclear cells is common in biological research. It widely accepted that primary are rendered unusable by several freezing cycles, although this practice might be very helpful when the material valuable and its re-collection impractical. To determine extent to which undergoing repeated cycles comparable one another fresh samples, we evaluated overall lymphocyte viability, their proliferation cytokine production capabilities, as well levels 27 cell...
Extracellular vesicles (EVs) mediate cell interactions in biological processes, such as receptor activation or molecule transfer. Estimates of variation by age and sex have been limited small sample size, no report has assessed the contribution genetic factors to levels EVs. Here, we evaluated blood 25 EV 3 platelet traits 974 individuals (933 genotyped) reported first genome-wide association study (GWAS) on these traits. all decreased with age, whereas trend for their surface markers was...
Maternal infections during pregnancy may increase the risk of psychiatric disorders in offspring. We recently demonstrated that activation peroxisome proliferator-activate receptor‐α (PPARα), with clinically available agonist fenofibrate, attenuates neurodevelopmental disturbances induced by maternal immune (MIA) rat hypothesized fenofibrate might reduce MIA-induced cytokine imbalance using a MIA model based on viral mimetic polyriboinosinic-polyribocytidilic acid [poly (I:C)]. By Bio-Plex...