Chris Hunter
A5009068138- Genomics and Phylogenetic Studies
- Scientific Computing and Data Management
- Research Data Management Practices
- Distributed and Parallel Computing Systems
- Glioma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Microbial Community Ecology and Physiology
- Environmental DNA in Biodiversity Studies
- Gene expression and cancer classification
- MicroRNA in disease regulation
- Wireless Networks and Protocols
- Genetics, Bioinformatics, and Biomedical Research
- Circular RNAs in diseases
- Cooperative Communication and Network Coding
- Mobile Ad Hoc Networks
- Lung Cancer Treatments and Mutations
- Biomedical Text Mining and Ontologies
- Genetic factors in colorectal cancer
- Logic, programming, and type systems
- Multi-Agent Systems and Negotiation
- Algorithms and Data Compression
- Subterranean biodiversity and taxonomy
- Genetic Mapping and Diversity in Plants and Animals
- Gut microbiota and health
- DNA Repair Mechanisms
China Science and Technology Publishing & Media
2014-2025
NanoBioImaging (China)
2021-2024
Wellcome Sanger Institute
2004-2023
GigaScience Press
2022
University of Pennsylvania
2005-2019
Samsung (United Kingdom)
2018
Stanford University
2014
European Bioinformatics Institute
2008-2013
Botswana Geoscience Institute
2013
Wellcome Trust
2008-2011
Abstract Protein kinases are frequently mutated in human cancer and inhibitors of mutant protein have proven to be effective anticancer drugs. We screened the coding sequences 518 (∼1.3 Mb DNA per sample) for somatic mutations 26 primary lung neoplasms seven cell lines. One hundred eighty-eight were detected 141 genes. Of these, 35 synonymous (silent) changes. This result indicates that most 188 “passenger” not causally implicated oncogenesis. However, an excess ∼40 nonsynonymous...
Abstract The panel of 60 human cancer cell lines (the NCI-60) assembled by the National Cancer Institute for anticancer drug discovery is a widely used resource. NCI-60 has been characterized pharmacologically and at molecular level more extensively than any other set lines. However, no systematic mutation analysis genes causally implicated in oncogenesis reported. This study reports sequence 24 known an assessment 4 homozygous deletions. One hundred thirty-seven oncogenic mutations were...
Abstract Malignant gliomas have a very poor prognosis. The current standard of care for these cancers consists extended adjuvant treatment with the alkylating agent temozolomide after surgical resection and radiotherapy. Although statistically significant increase in survival has been reported this regimen, nearly all recur become insensitive to further class agents. We sequenced 500 kb genomic DNA corresponding kinase domains 518 protein kinases each nine gliomas. Large numbers somatic...
An activating point mutation in codon 12 of the HRAS gene was first somatic identified a human cancer and established role mutations as common driver oncogenesis. Since then, there have been over 11,000 three RAS (HRAS, KRAS NRAS) genes codons 12, 13 61 reported literature. We report here identification recurrent missense at alanine 146, highly conserved residue guanine nucleotide binding domain. In two independent series colorectal cancers from Hong Kong United States we detected A146 7/126...
Metagenomics is a relatively recently established but rapidly expanding field that uses high-throughput next-generation sequencing technologies to characterize the microbial communities inhabiting different ecosystems (including oceans, lakes, soil, tundra, plants and body sites). brings with it number of challenges, including management, analysis, storage sharing data. In response these we have developed new metagenomics resource (http://www.ebi.ac.uk/metagenomics/) allows users easily...
Efficient response to the pandemic through mobilization of larger scientific community is challenged by limited reusability available primary genomic data. Here, Genomic Standards Consortium board highlights essential need for contextual data FAIRness, empowering key data-driven biological questions.
Dramatic increases in the throughput of nucleotide sequencing machines, and promise ever greater performance, have thrust bioinformatics into era petabyte-scale data sets. Sequence repositories, which provide feed for these sets worldwide computational infrastructure, are challenged by impact volumes. The European Nucleotide Archive (ENA; http://www.ebi.ac.uk/embl), comprising EMBL Database Ensembl Trace Archive, has identified challenges storage, movement, analysis, interpretation...
Abstract The protein kinase gene family is the most frequently mutated in human cancer. Previous work has documented activating mutations KIT receptor tyrosine testicular germ‐cell tumors (TGCT). To investigate further potential role of kinases development TGCT and to characterize prevalence patterns point these tumors, we have sequenced coding exons splice junctions annotated 518 genes a series seven seminomas six nonseminomas. Our results show remarkably low mutation frequency, with only...
The flexible interface between the medium access layer and custom physical of Rice University Wireless Open-Access Research Platform (WARP) provides a high performance research tool for clean-slate cross designs. As we target community platform, have implemented various basic PHY MAC technologies over WARP. Moreover, are implementing cross-layer schemes such as rate adaptation crosslayer MIMO protocols. In this demo, demonstrate flexibility interaction WARP layers by showing capability to...
In this paper, we introduce the wireless open-access research platform (WARP) developed at CMC lab, Rice University. WARP provides a scalable and configurable mainly designed to prototype communication algorithms for educational oriented applications. Its programmability flexibility makes it easy implement various physical network layer protocols standards. Moreover, online repository is used document share different architectures cross-layer designs centers. This fast solution students...
Abstract CD4+ T cells with a block in the NF-κB signaling pathway exhibit decreases Th1 responses and diminished nuclear levels of multiple transactivating NF-κB/Rel/IκB proteins. To determine lineage-intrinsic contributions these transactivators to Th differentiation, from mice deficient specific subunits were cultured exogenous cytokines promoting either or Th2 differentiation. RelB-deficient exhibited dramatic defects differentiation IFN-γ production, whereas no consistent defect was...
The European Nucleotide Archive (ENA; http://www.ebi.ac.uk/ena) is Europe's primary nucleotide sequence archival resource, safeguarding open data access, engaging in worldwide collaborative exchange and integrating with the scientific publication process. ENA has made significant contributions to arena as an active proponent of extending traditional collaboration cover capillary next-generation sequencing information. We have continued co-develop metadata representation formats our...
We demonstrate how a classical taxonomic description of new species can be enhanced by applying generation molecular methods, and novel computing imaging technologies. A cave-dwelling centipede, Eupolybothrus cavernicolus Komerički & Stoev sp. n. (Chilopoda: Lithobiomorpha: Lithobiidae), found in remote karst region Knin, Croatia, is the first eukaryotic for which, addition to traditional morphological description, we provide fully sequenced transcriptome, DNA barcode, detailed anatomical...
The 32nd Plant and Animal Genomes (PAG) Conference 2025 was a whirlwind of fascinating talks innovative research! As in previous years (see blog posts here & here), the event spanned 5 complete days, this time organisers reporting 2349 registered attendees from 64 countries. top represented countries were (highest number participants first); USA, Canada, UK, Germany China.
A select group of pathogens infect neurons in the brain. Prior dogma held that were "defenseless" against infecting microbes, but many studies suggest can mount anti-microbial defenses. However, a knowledge gap understanding how respond vitro and vivo to different classes micro-organisms remains. To address this gap, we compared transcriptional dataset derived from primary neuron cultures (PNCs) infected with neurotropic intracellular parasite Toxoplasma gondii injected T. protein . These...
The Biocuration 2025 meeting held in Kansas City USA at the Stowers Institute (April 5-9) was a well organized blend of in-person and virtual participants. As regular attendees International Society (ISB) members (see previous reports) GigaScience Press represented by two GigaDB team, Chris Hunter Bastien Molcrette.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInteraction of crystal violet with nucleic acidsL. P. G. Wakelin, A. Adams, C. Hunter, and M. J. WaringCite this: Biochemistry 1981, 20, 5779–5787Publication Date (Print):September 29, 1981Publication History Published online1 May 2002Published inissue 29 September 1981https://pubs.acs.org/doi/10.1021/bi00523a021https://doi.org/10.1021/bi00523a021research-articleACS PublicationsRequest reuse permissionsArticle Views813Altmetric-Citations39LEARN...
The European Nucleotide Archive (ENA; http://www.ebi.ac.uk/ena), Europe's primary nucleotide sequence resource, captures and presents globally comprehensive nucleic acid associated information. Covering the spectrum from raw data to assembled functionally annotated genomes, ENA has witnessed a dramatic growth resulting advances in sequencing technology ever broadening application of methodology. During 2011, we have continued operate extend broad range services. In particular, released major...
The inner membrane complex (IMC), a series of flattened vesicles at the periphery apicomplexan parasites, is thought to be important for parasite shape, motility and replication, but few IMC proteins that function in these processes have been identified. TgPhIL1, Toxoplasma gondii protein was previously identified through photosensitized labeling with 5-[125I] iodonapthaline-1-azide, associates and/or underlying cytoskeleton concentrated apical end parasite. Orthologs TgPhIL1 are found other...
Wireless communication standards are developed at an ever-increasing rate of pace, and significant amounts effort is put into research for new methods concepts. On the physical layer, such topics include MIMO, cooperative communication, error control coding, whereas