A5103111374- Cellular Mechanics and Interactions
- Peripheral Neuropathies and Disorders
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Hereditary Neurological Disorders
- Mitochondrial Function and Pathology
- Immunotherapy and Immune Responses
- Cell Image Analysis Techniques
- Muscle Physiology and Disorders
- Botulinum Toxin and Related Neurological Disorders
- Parathyroid Disorders and Treatments
- Glycosylation and Glycoproteins Research
- Neurosurgical Procedures and Complications
- Pregnancy and Medication Impact
- Fibroblast Growth Factor Research
- Ethics in medical practice
- Galectins and Cancer Biology
- Neurological diseases and metabolism
- Gastrointestinal disorders and treatments
- Electrochemical Analysis and Applications
- Long-Term Effects of COVID-19
- Cerebrovascular and genetic disorders
- Neurological disorders and treatments
- Intracerebral and Subarachnoid Hemorrhage Research
Complejo Hospitalario de Salamanca
2020-2024
Instituto de Investigación Biomédica de Salamanca
2022
Universidad de Salamanca
2022
Universidad de Granada
1997-2018
Boston Children's Hospital
2005-2007
Harvard University
2007
Hospital Universitario de Gran Canaria Doctor Negrín
2004
University of Córdoba
1997
Wiskott-Aldrich syndrome protein (WASP) is in a complex with WASP-interacting (WIP). WASP levels, but not mRNA were severely diminished T cells from WIP(-/-) mice and increased by introduction of WIP these cells. The binding domain was shown to protect degradation calpain vitro. Treatment the proteasome inhibitors MG132 bortezomib levels B lymphocytes two WAS patients missense mutations (R86H T45M) that disrupt binding. inhibitor calpeptin activated patients, primary or mice. Despite its...
Background: Mustard IgE‐mediated allergy is supposed to be a rare cause of food allergy, and its clinical features cross‐reactivities have not been fully elucidated. Methods: A prospective study was carried out, recruiting mustard allergic patients, paired control subjects. questionnaire administered, skin‐prick tests (SPT) with panels aeroallergens foods, serum extraction for in vitro double‐blind placebo‐controlled challenges (DBPCFC) were performed. Results: Thirty‐eight mainly adult...
Homing of lymphocytes to tissues is a biologically important multistep process that involves selectin-dependent rolling, integrin-dependent adhesion and chemokine-directed chemotaxis. The actin cytoskeleton plays central role in lymphocyte motility. Wiskott–Aldrich syndrome protein (WASP), the product gene mutated syndrome, its partner, protein-interacting (WIP), play roles re-organization T lymphocytes. We used mice with disruption WASP WIP genes examine cell homing. homing spleen lymph...
Charcot-Marie-Tooth (CMT) disease is classified considering the neurophysiological and histological findings, inheritance pattern underlying genetic defect. In recent years, with advent of next generation sequencing, complexity has increased exponentially, expanding knowledge about pathways, having an impact in clinical management. The aim this guide to offer recommendations for diagnosis, prognosis, monitoring treatment Spain. This consensus guideline been developed by a multidisciplinary...
Carbamazepine is an anticonvulsant drug with multiple mechanisms of action, which condition the presence a characteristic clinical picture after overingestion drug. We expose case report about patient who, in context attempted suicide, presented acute intoxication by benzodiazepines and carbamazepine, presenting fluctuations level consciousness, even gaze deconjugation, almost unreactive coma generalized hypotonia.
Abstract CD43 is the major leukocyte sialoglycoprotein that plays important functional roles in neutrophils and lymphocytes. However, expression of on human natural killer (NK) cells its participation regulation NK activity has not been studied. We have therefore investigated isoforms cell subpopulations as well role this molecule activation cytotoxicity. found CD56bright CD56dim express different sialylated forms CD43, observing induces change tetrasaccharide O-glycans to hexasaccha-ride...
Objective To examine if peripheral T lymphocytes from HIV-infected individuals show abnormalities in the surface expression of CD43, major sialoglycoprotein leukocytes. Design A series 86 HIV-positive was studied. The subjects, grouped by their CD4 cell count, were different stages disease as defined Centers for Disease Control and Prevention (CDC). Methods Peripheral leukocytes isolated examined double triple immunofluorescence flow cytometric Western blot analyses with monoclonal...
Much has been written and said about Paul Greengard, Nobel Prize in Medicine, one of the greatest neuroscientists history. As we approach centenary his birth, now is not a bad time to look back once more learn from such fantastic figure neuroscience. We performed literature search PubMED database Greengard's publications. Greenengard's first publications date 1954, particular, with work entitled "Some relationships between action potential, oxygen consumption coenzyme content degenerating...
Organic Law 3/2021, of March 24, regulating euthanasia, has intensified a harsh debate. A priori, it is conflict bioethical values and different anthropological vision between the parties, however, we must not forget that perhaps before considering any debate, necessary to correctly interpret what patient really wants when he states die. In our health system in society, there are certain traits needs person ignored, urgently require attention for patient. Discovering meaning one's life,...
Abstract Introduction : Among the neurological diseases possibly associated with COVID-19 (coronavirus disease 2019) infection, Guillain-Barré syndrome has been postulated since start of pandemic, even more so when vaccination also come into play. Objectives A bibliographic review is carried out to assess true risks suffering secondary against SARS-COV2 ( severe acute respiratory coronavirus 2 ) infection and developing it infection. Material methods search for articles was in PubMed-MEDLINE...