A5002577290- Tryptophan and brain disorders
- Chaos control and synchronization
- Neurological disorders and treatments
- Stress Responses and Cortisol
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Stroke Rehabilitation and Recovery
- Heart Rate Variability and Autonomic Control
- Quantum chaos and dynamical systems
- Neural Networks and Applications
- Advanced Neuroimaging Techniques and Applications
- Complex Systems and Time Series Analysis
- EEG and Brain-Computer Interfaces
- Neuroinflammation and Neurodegeneration Mechanisms
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Genetic Neurodegenerative Diseases
- Muscle activation and electromyography studies
- Chaos-based Image/Signal Encryption
- Prenatal Substance Exposure Effects
- Diversity and Career in Medicine
- Dementia and Cognitive Impairment Research
- Musculoskeletal Disorders and Rehabilitation
- Advanced Combustion Engine Technologies
- Optical Imaging and Spectroscopy Techniques
University of Michigan
2020-2024
Akron Children's Hospital
2021
Columbia University
2015-2018
University of Minnesota
2016
Georgia State University
2014-2015
Emory University
2007-2014
NutriNeuro
2012
University of Modena and Reggio Emilia
2012
Winship Cancer Institute
2011-2012
Goodman Research Group (United States)
2012
<h3>Context</h3>Increased concentrations of inflammatory biomarkers predict antidepressant nonresponse, and cytokines can sabotage circumvent the mechanisms action conventional antidepressants.<h3>Objectives</h3>To determine whether inhibition cytokine tumor necrosis factor (TNF) reduces depressive symptoms in patients with treatment-resistant depression an increase baseline plasma biomarkers, including high-sensitivity C-reactive protein (hs-CRP), TNF, its soluble receptors, predicts...
Context: Inflammatory cytokines or cytokine inducers can alter basal ganglia activity, including reducing responsiveness to rewarding stimuli that may be mediated by effects on dopamine function.Objectives: To determine whether long-term administration of the inflammatory interferon alfa reduces response reward and such changes are associated with decreased presynaptic striatal function altered behavior.
Brain areas within the motor system interact directly or indirectly during motor-imagery and motor-execution tasks. These interactions their functionality can change following stroke recovery. How brain network reorganize recover recovery treatment are not well understood. To contribute to answering these questions, we recorded blood oxygenation-level dependent (BOLD) functional magnetic resonance imaging (fMRI) signals from 10 survivors evaluated dynamical causal modeling (DCM)-based...
Neuroprotection for Parkinson's disease (PD) remains elusive. Biomarkers hold the promise of removing roadblocks to therapy development. The National Institute Neurological Disorders and Stroke has therefore established Disease Program promote discovery PD biomarkers use in phase II III clinical trials.Using a novel consortium design, Biomarker is focused on development laboratory-based diagnosis, progression, prognosis. Standardized operating procedures pooled reference samples were created...
Reduced basal ganglia function has been associated with fatigue in neurologic disorders, as well patients exposed to chronic immune stimulation. Patients syndrome (CFS) have shown exhibit symptoms suggestive of decreased including psychomotor slowing, which turn was correlated fatigue. In addition, CFS found increased markers activation. order directly test the hypothesis CFS, we used functional magnetic resonance imaging examine neural activation a reward-processing (monetary gambling) task...
Multiple cortical areas of the human brain motor system interact coherently in low frequency range (<0.1 Hz), even absence explicit tasks. Following stroke, interactions are functionally disturbed. How these affected and how functional organization is regained from rehabilitative treatments as people begin to recover behaviors has not been systematically studied. We recorded intrinsic magnetic resonance imaging (fMRI) signals 30 participants: 17 young healthy controls 13 aged stroke...
α-Synuclein is the major component of Lewy bodies and a candidate biomarker for neurodegenerative diseases in which are common, including Parkinson's disease dementia with bodies. A large body literature suggests that these disorders characterized by reduced concentrations α-synuclein cerebrospinal fluid (CSF), overlapping compared to healthy controls variability across studies. Several reasons can account this variability, technical ones, such as inter-assay inter-laboratory variation...
Coherent network oscillations (< 0.1 Hz) linking distributed brain regions are commonly observed in the during both rest and task conditions. What oscillatory exists how change connectivity strength, frequency direction when going from to explicit topics of recent inquiry. Here, we study within sensorimotor able-bodied individuals using hemodynamic activity as measured by functional near-infrared spectroscopy (fNIRS). Using spectral interdependency methods, examined supplementary motor area...
Stroke often involves primary motor cortex (M1) and its corticospinal projections (CST). As hand function is critically dependent on these structures, recovery incomplete. The neuronal substrate supporting affected not well understood but likely reorganized M1 CST of the lesioned hemisphere (M1IL CSTIL). We hypothesized that in chronic stroke related to structural functional reorganization M1IL CSTIL. tested 18 patients with ischemic involving or CST. Their was compared age-matched healthy...
Parkinson's disease (PD) is a complex neurodegenerative disorder that manifests through hallmark motor symptoms, often accompanied by range of non-motor symptoms. There putative delay between the onset process, marked death dopamine-producing cells, and creating an urgent need to develop biomarkers may yield early PD detection. Neuroimaging offers non-invasive approach examining potential utility vast number functional structural brain characteristics as biomarkers. We present statistical...
Background. Stroke often involves primary motor cortex (M1) and its corticospinal (CST) projections. As hand function is critically dependent on these structures, recovery incomplete. Objective. To determine whether impaired in patients with chronic ischemic stroke involving M1 or CST benefits from the enhancing effect of Hebbian-type stimulation (pairing afferent activity a specific temporal relationship) plasticity function. Methods. In double-blind, randomized, sham-controlled design, 20...
Although there may be some disagreement as to the precise definition of chaos, it is generally characterized a nonlinear, deterministic phenomenon. For class common chaotic systems, this paper introduces equivalent descriptions in form linear, time-invariant (LTI) systems with random inputs. Such models have many advantages they are much better matched traditional signal and system theory. The outputs these LTI will shown indistinguishable from corresponding systems. Specifically, for given...
Previous studies suggest a negative association between prenatal polybrominated diphenyl ethers (PBDEs) exposure and child cognitive psychomotor development. However, the timing of relationship PBDE neurodevelopment is still unclear. We examined concentration at two different times (early late pregnancy) function in children 6-8 years age.Eight hundred pregnant women were recruited 2007 2009 from Sherbrooke, Canada. Four congeners (BDE-47, -99, -100, -153) measured maternal plasma samples...
knowledge within developmental paediatrics.This book can be recommended as a
Background Low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) protocols targeting primary motor cortex (M1) are used in rehabilitation of neurological diseases for their therapeutic potential, safety, and tolerability. Although lower intensity LF-rTMS can modulate M1 neurophysiology, results variable, a systematic assessment its dose effect is lacking. Objectives To determine the dose-response on stimulated non-stimulated M1. Methods In sham-controlled randomized...
In this paper, we first demonstrate that the dynamics of archetypal chaotic system based on sawtooth map have a natural interpretation as noncausally filtered Bernoulli noise. This result is then extended to introduce an entire family anticausal filters which can produce (deterministic) behavior. Finally, replacing noise source with feedback shift register and truncating impulse response results in pseudo-chaos: colored pseudo-noise. By relying registers, pseudo-chaotic implementations avoid...
Sequences generated by chaotic systems have been proposed as replacements for the traditional pseudo-noise sequences used in direct-sequence spread spectrum systems. Such often require that receiver maintain synchronization tracking sequence transmitter. A method previously introduced to track state of a system from an observed is extended states multiple, independent systems, again based on single sequence. One possible use this scheme might be modified code-division multiplexing...
Objectives Conduct a functional magnetic resonance (fMRI) study using monetary win‐lose gambling task that strongly activates basal ganglia to test hypothesis of decreased function in chronic fatigue syndrome (CFS). Methods Participants included 18 CFS subjects (1994 case definition) and 41 non‐fatigued controls matched on age, sex race who were free psychotropic medications significant depression (Zung Depression score <60). The general activation pattern for contrast across all was...