A5090932219- Neonatal and fetal brain pathology
- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Neural dynamics and brain function
- Sleep and Wakefulness Research
- Neurological Complications and Syndromes
- Neuroscience of respiration and sleep
- Atomic and Subatomic Physics Research
- Drug Transport and Resistance Mechanisms
- Autoimmune Neurological Disorders and Treatments
- Genetics and Neurodevelopmental Disorders
- Cardiac electrophysiology and arrhythmias
- Sphingolipid Metabolism and Signaling
- Fetal and Pediatric Neurological Disorders
- Acute Myeloid Leukemia Research
- Neuroscience and Music Perception
- Vascular Malformations Diagnosis and Treatment
- Blind Source Separation Techniques
- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Multiple Sclerosis Research Studies
- Pharmacological Effects and Toxicity Studies
- Functional Brain Connectivity Studies
- Moyamoya disease diagnosis and treatment
- Olfactory and Sensory Function Studies
Washington University in St. Louis
2021-2025
St. Louis Children's Hospital
2021-2024
Boston Children's Hospital
2016
Harvard University
2016
Rapid-onset Obesity with Hypothalamic Dysfunction, Hypoventilation and Autonomic Dysregulation (ROHHAD), is a severe pediatric disorder of uncertain etiology resulting in hypothalamic dysfunction frequent sudden death. Frequent co-occurrence neuroblastic tumors have fueled suspicion an autoimmune paraneoplastic neurological syndrome (PNS); however, specific anti-neural autoantibodies, hallmark PNS, not been identified. Our objective to determine if underlies ROHHAD.Immunoglobulin G (IgG)...
Corpus callosotomy (CC) is a palliative surgical intervention for patients with medically refractory epilepsy that has evolved in recent years to include less-invasive alternative the use of laser interstitial thermal therapy (LITT). LITT works by heating stereotactically placed fiber ablative temperatures under real-time magnetic resonance imaging (MRI) thermometry. This study aims (1) describe outcomes CC large cohort children epilepsy, (2) compare anterior and complete CC, (3) review as...
Purpose: Neonatal encephalopathy (NE) is a commonly encountered, highly morbid condition with pressing need for accurate epilepsy prognostication. We evaluated the use of automated EEG prediction early life after NE treated therapeutic hypothermia (TH). Methods: conducted retrospective analysis neonates moderate-to-severe who underwent TH at single center. The first 24 hours data artifact removal and quantitative (qEEG) subsequent evaluation qEEG feature accuracy 1st 20th hour risk...
Neonatal encephalopathy (NE) is a common cause of neurodevelopmental morbidity. Tools to accurately predict outcomes after therapeutic hypothermia remain limited. We evaluated novel EEG biomarker, macroperiodic oscillations (MOs), outcomes.
Abstract Importance Quantitative electroencephalography (qEEG) has been used in the neonatal intensive care unit (NICU) for several decades. Recent innovations have led to renewed interest expanding its role NICU with goal of improving both acute neonates and longer‐term outcomes. Observations EEG is primarily identify seizures. Sophisticated analysis can detect other neurological emergencies provide additional information about short‐ long‐term neurodevelopmental epileptic prognosis. Using...
Abstract Purpose Rasmussen encephalitis (RE) is a very rare chronic neurological disorder of unilateral inflammation the cerebral cortex. Hemispherotomy provides best chance at achieving seizure freedom in RE patients, but with significant risks and variable long-term outcomes. The goal this study to utilize our multicenter pediatric cohort characterize if differences pathology and/or imaging characterization may provide window into post-operative outcomes, which turn could guide...
Purpose: Seizures occur in up to 40% of neonates with neonatal encephalopathy. Earlier identification seizures leads more successful seizure treatment, but is often delayed because limited availability continuous EEG monitoring. Clinical variables poorly stratify risk, and use risk has previously been by need for manual review artifact exclusion. The goal this study compare the utility automatically extracted quantitative (qEEG) features stratification. Methods: We conducted a retrospective...
The authors assessed the safety and accuracy of stereoelectroencephalography (SEEG) electrode implantation in pediatric patients who had previously undergone craniotomy compared to those without prior cranial surgery.
Abstract Purpose Rasmussen encephalitis (RE) is a very rare chronic neurological disorder of unilateral inflammation the cerebral cortex. Hemispherotomy provides best chance at achieving seizure freedom in RE patients, but with significant risks and variable long-term outcomes. The goal this study to utilize our multicenter pediatric cohort characterize if differences pathology and/or imaging characterization may provide window into postoperative outcomes, which turn could guide decision...
Sleep is an essential physiologic process, which frequently disrupted in children with illness and/or injury. Accurate identification and quantification of sleep may provide insights to improve long-term clinical outcomes. Traditionally, however, the stages has relied on resource-intensive time-consuming gold standard polysomnogram. We sought use limited EEG data, converted into density spectrum array EEG, accurately identify a pediatric population.
Division of Epilepsy and Clinical Neurophysiology, Department Neurology, Boston Children's Hospital Harvard Medical School, Boston, Massachusetts, U.S.A. The authors declare no conflicts interest.
Kleine-Levin syndrome (KLS) is a rare disorder characterized by episodic bouts of severe hypersomnia associated with cognitive and behavioral abnormalities normal alertness functioning in between episodes. The pathophysiology unclear but may involve neurotransmitter abnormalities, hypothalamic/thalamic dysfunction, viral/autoimmune etiology, or circadian abnormalities. No single treatment has been shown to be reliably efficacious; lithium demonstrated the most consistent efficacy, although...
Abstract Objective To determine the clinical variances between strokes and stroke mimics in a pediatric immunocompromised population that consists of children with central nervous system (CNS) non-CNS malignancies history solid organ transplantation. Methods We performed retrospective cohort analysis alert activations patients high-grade gliomas, low-grade atypical teratoid rhabdoid tumors, rare CNS B-cell acute lymphoblastic leukemia, T-cell osteosarcoma, transplants at St. Louis Children’s...
Abstract ROHHAD ( R apid-onset O besity with H ypothalamic Dysfunction, ypoventilation and A utonomic D ysregulation) is a rare, yet severe pediatric disorder resulting in hypothalamic dysfunction frequent sudden death. Genetic other investigations have failed to identify an etiology or diagnostic test. Frequent co-occurrence of neuroblastic tumors (NTs) cerebrospinal fluid inflammation point autoimmune paraneoplastic neurological syndrome (PNS); however, specific anti-neural autoantibodies,...