A5009116857- Acute Ischemic Stroke Management
- Autism Spectrum Disorder Research
- Ion Transport and Channel Regulation
- Blood Pressure and Hypertension Studies
- Hemoglobinopathies and Related Disorders
- Cerebrovascular and Carotid Artery Diseases
- Genomics and Rare Diseases
- Metabolism and Genetic Disorders
- Autoimmune and Inflammatory Disorders Research
- Epilepsy research and treatment
- Atrial Fibrillation Management and Outcomes
- Genetics and Neurodevelopmental Disorders
- Ocular Diseases and Behçet’s Syndrome
- Musculoskeletal pain and rehabilitation
- Lipoproteins and Cardiovascular Health
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Health and Disease Prevention
- Peripheral Artery Disease Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Mitochondrial Function and Pathology
- Neurotransmitter Receptor Influence on Behavior
- Social Robot Interaction and HRI
- Folate and B Vitamins Research
- Gastroesophageal reflux and treatments
- Alcohol Consumption and Health Effects
Aristotle University of Thessaloniki
2014-2024
Hospices Civils de Lyon
2020-2024
ERN EpiCARE
2021-2024
Centre de Recherche en Neurosciences de Lyon
2019-2024
Papageorgiou General Hospital
2017-2024
European Clinical Research Infrastructure Network
2024
Hôpital Femme Mère Enfant
2024
Cyprus University of Technology
2011-2023
Telio (Norway)
2023
Adult and Pediatric Dermatology
2022
<h3>Abstract</h3> In December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, Hubei Province, China. No specific treatment has been established against disease-2019 (COVID-19) so far. Therefore, it is urgently needed to identify effective antiviral agents for the of this disease, and several approved drugs such as lopinavir have evaluated. Here, we report that nelfinavir, an HIV-1 protease inhibitor, potently inhibits replication SARS-CoV-2. The...
Importance Alternating hemiplegia of childhood (AHC) is a disorder that can result from pathogenic variants in ATP1A3 -encoded sodium-potassium adenosine triphosphatase alpha 3 (ATP1A3). While AHC primarily neurologic disease, some individuals experience sudden unexplained death (SUD) potentially associated with cardiac arrhythmias. Objective To determine the impact on electrophysiology and whether lethal ventricular arrhythmias are SUD patients AHC. Design, Setting, Participants In this...
Primary mitochondrial diseases (PMDs) are common inborn errors of energy metabolism, with an estimated prevalence one in 4300. These disorders typically affect tissues high requirements, including heart, muscle and brain. Epilepsy may be the presenting feature PMD, can difficult to treat often represents a poor prognostic feature. The aim this study was develop guidelines consensus recommendations on safe medication use seizure management epilepsy.
The nucleus accumbens (NAc) is a critical brain area for reward and motivated behavior. Accumulating evidence suggests that altered function of the transcription factor cAMP response element binding protein (CREB) within NAc involved in depressive In rats, stress activates CREB NAc, elevation expression this region produces depressive-like behaviors are accompanied by activation CREB-regulated target genes. seem to be due, at least part, CREB-mediated increases dynorphin function, because...
Introduction: Acute lymphoblastic leukemia (ALL) is the most prevalent childhood malignancy. Despite high cure rates, several questions remain regarding predisposition, response to treatment, and prognosis of disease. The role intermediary metabolism in individualized mechanistic pathways disease unclear. We have hypothesized that children with any (sub)type ALL a distinct metabolomic fingerprint at diagnosis when compared: (i) control group; (ii) different ALL; (iii) end induction...
Abstract Purpose To assess and compare the characteristics, therapy interventions, occurrence of uveitis ocular complications in children with juvenile idiopathic arthritis (JIA) screened examined for Gothenburg, Sweden, over 20 years. Biological immunomodulatory treatment was increasingly used during second half Methods Data were retrospectively collected from JIA at Queen Silvia Children's Hospital between 2012 2021. These data compared those a previously published study (the first cohort)...
Patient safety has been a priority for many societies and health care systems in the last decades. Identification of preventable risks aversion potentially unsafe situations fatal complications maternity units is life saving. The explicit need to focus on quality underpins aim study initially evaluate culture teamwork climate public Maternity Units 5 Regional Hospitals Cyprus as measured by validated attitudes tool. Data were collected from 140 midwives working sector all over Greek Version...
To evaluate the association of nonalcoholic fatty liver disease (NAFLD) with acute ischemic stroke severity and in-hospital outcome.We prospectively studied all patients who were admitted in our Department between September 2010 August 2012 (n = 415; 39.5% males, mean age 78.8 ± 6.6 years). The was assessed National Institutes Health Stroke Scale (NIHSS) score at admission. NALFD defined as serum alanine aminotransferase and/or aspartate levels above upper limit normal absence other causes...
Abstract Chronic morphine leads to compensatory up‐regulation of cAMP signaling pathways in numerous brain regions. One potential consequence up‐regulated is increased phosphorylation response element binding protein (CREB), a transcription factor that may regulate neuroadaptations related dependence. Altered gene expression within the nucleus accumbens (NAc), ventral component striatum receives substantial dopaminergic input, play role some motivational aspects opiate withdrawal. To...
To describe clinical features, risk factors and complications in a cohort of Swedish children with juvenile idiopathic arthritis (JIA) screened for uveitis between 2002 2011.Medical records 299 JIA (93 male, 206 female; median age 5.0 years at diagnosis) were retrospectively scrutinized focusing on subtype JIA, onset arthritis/uveitis, presence antinuclear antibodies (ANA) ophthalmological status.Uveitis was found 32 (11%) children, 78% bilaterally affected. The who developed 2.5 (range...
Recent data suggest that blood pressure (BP) variability confers increased cardiovascular risk independently of BP. We aimed to evaluate the association between BP during acute phase ischemic stroke and in-hospital outcome.We prospectively studied 608 consecutive patients admitted with (39.5% males, age: 79.1±6.6 years). Variability in was assessed SD coefficient variation systolic (SBP) diastolic (DBP) first 2 3 days hospitalization. The outcome dependency rates at discharge...
Langerhans cell histiocytosis (LCH) is a rare hematologic disorder that results from the clonal multiplication and accumulation of immature dendritic cells. Its reported incidence rate varies, but considered to be 2.6-8.9 per million children who are <15 years age each year. It may affect any system or organ. The present study 4 pediatric LCH cases in order highlight heterogeneity initial presentation, pitfalls mislead clinicians delay diagnosis. clinical features, as well pathognomonic...
Abstract Objective The increasingly rapid pace of advancement in genetic testing may lead to inequalities technical and human resources with a negative impact on optimal epilepsy clinical practice. In this view, the European Reference Network (ERN) for Rare Complex Epilepsies EpiCARE conducted survey addressing several aspects accessibility, availability, costs, standard practices across ERN centers. Methods An online Google form was sent 70 representatives Descriptive statistics qualitative...
BACKGROUND The relationship between blood pressure (BP) at admission for acute ischemic stroke and outcome is controversial. We aimed to assess whether only systolic BP (SBP), diastolic (DBP), both or neither predict these associations differ patients with without a history of hypertension. METHODS prospectively studied all who were admitted (n = 415; 39.5% males, age 78.8±6.6 years). severity was assessed the National Institutes Health Stroke Scale (NIHSS). evaluated dependency discharge...
Abstract Background and aim In 21st century, there has been an increasing interest in vaginal birth after previous caesarean section (VBAC) Cyprus, a country with very high operative rate. Research-based evidence of women’s VBAC experiences Cyprus is non-existent, despite its significance for the well-being mothers families. The this study to gain insight into lived experience Cyprus. are explored first time Method qualitative exploratory nature. Data were collected through semi-structured...
Haematological and clinical characteristics have been examined in 30 patients with homozygous sickle cell (SS) disease, 28 cell-beta zero thalassaemia, 21 cell-beta+ thalassaemia. The latter could be divided into three groups on their molecular basis HbA levels, four subjects an IVS-2 nt 745 mutation having 3-6% (designated S beta+ thalassaemia type I), 14 IVS-1 110 8-15% II), 6 20-25% III). Comparisons were conducted between SS beta II. Compared to both syndromes had higher HbA2 levels red...