A5083878486- Acute Ischemic Stroke Management
- CAR-T cell therapy research
- Blood Pressure and Hypertension Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cerebrovascular and Carotid Artery Diseases
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Atrial Fibrillation Management and Outcomes
- Acute Myeloid Leukemia Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Virus-based gene therapy research
- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Disease Prevention
- Liver Disease Diagnosis and Treatment
- Peripheral Artery Disease Management
- Neurological Disorders and Treatments
- Chronic Myeloid Leukemia Treatments
- Stroke Rehabilitation and Recovery
- Nanowire Synthesis and Applications
- Venous Thromboembolism Diagnosis and Management
- Diabetic Foot Ulcer Assessment and Management
- Liver Disease and Transplantation
- Lymphoma Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Viral Infectious Diseases and Gene Expression in Insects
King's College Hospital
2023-2025
King's College Hospital NHS Foundation Trust
2023-2025
London Cancer
2025
King's College London
2025
National Health Service
2025
G. Papanikolaou General Hospital
2017-2020
AHEPA University Hospital
2011-2019
Aristotle University of Thessaloniki
2011-2019
Stroke is a devastating event that carries potential for long-term disability. Malnutrition frequently observed in patients with stroke, and dysphagia contributes to malnutrition risk. During both the acute phase of stroke rehabilitation, specific nutritional interventions context multidisciplinary team effort can enhance recovery neurocognitive function. Early identification management dietary modifications or therapeutic strategies ensure adequate intake should receive more attention,...
Data on the impact of ethnic and socioeconomic factors Chimeric antigen receptor (CAR) T-cell therapy (access outcomes are limited, but key to understand whether results from registration trials generalizable real-world patient populations. Here, we analysed ethnicity, deprivation referral patterns in a cohort 314 large B-cell lymphoma patients approved for third-line CD19 CAR-T across three UK centres. Patients deprived areas had lower infusion rate compared low (73% vs. 86%, p = 0.04)....
To evaluate the association of nonalcoholic fatty liver disease (NAFLD) with acute ischemic stroke severity and in-hospital outcome.We prospectively studied all patients who were admitted in our Department between September 2010 August 2012 (n = 415; 39.5% males, mean age 78.8 ± 6.6 years). The was assessed National Institutes Health Stroke Scale (NIHSS) score at admission. NALFD defined as serum alanine aminotransferase and/or aspartate levels above upper limit normal absence other causes...
Recent data suggest that blood pressure (BP) variability confers increased cardiovascular risk independently of BP. We aimed to evaluate the association between BP during acute phase ischemic stroke and in-hospital outcome.We prospectively studied 608 consecutive patients admitted with (39.5% males, age: 79.1±6.6 years). Variability in was assessed SD coefficient variation systolic (SBP) diastolic (DBP) first 2 3 days hospitalization. The outcome dependency rates at discharge...
Background: Allogeneic haematopoietic stem-cell transplant is a potentially curative option for high-risk acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) patients. Post-transplant cyclophosphamide administration allows selection of haploidentical donors in patients who are eligible the procedure, but do not have fully matched donor, since it can overcome HLA barrier. There still an active debate on whether intensification conditioning regimen necessary with when peripheral...
BACKGROUND The relationship between blood pressure (BP) at admission for acute ischemic stroke and outcome is controversial. We aimed to assess whether only systolic BP (SBP), diastolic (DBP), both or neither predict these associations differ patients with without a history of hypertension. METHODS prospectively studied all who were admitted (n = 415; 39.5% males, age 78.8±6.6 years). severity was assessed the National Institutes Health Stroke Scale (NIHSS). evaluated dependency discharge...
It is unclear whether prior antidiabetic treatment affects stroke severity and outcome. To evaluate this association, we prospectively studied all patients who were admitted in our Department with acute ischaemic (n = 378, mean age 78.8 ± 6.5 years). The of was assessed at admission the National Institutes Health Stroke Scale. outcome modified Rankin Scale discharge in-hospital mortality. A total 123 had type 2 diabetes mellitus. At admission, there a trend for lower treated dipeptidyl...
Limited and conflicting data exist on outcomes of patients with extramedullary relapses (EMRs) after allogeneic hematopoietic cell transplantation (allo-HCT) for acute leukemias. We retrospectively reviewed charts consecutive allo-HCT recipients who underwent in our center the indication leukemia (July 1990 to July 2018). Incidences isolated EMR (iEMR) bone marrow relapse (BMR) were calculated using cumulative incidence (CI) analysis, each treatment-related mortality considered a competing...
Peripheral arterial disease (PAD) is frequently present in patients with acute ischemic stroke. However, there are limited data regarding the association between ankle brachial index (ABI) ≤ 0.90 (which diagnostic of PAD) or > 1.40 (suggesting calcified arteries) and severity stroke in-hospital outcome this population. We aimed to evaluate these associations stroke.We prospectively studied 342 consecutive admitted for (37.4 % males, mean age 78.8 ± 6.4 years). The was assessed National...
It is unclear whether antihypertensive treatment before stroke affects acute ischemic severity and outcome. To evaluate this association, the authors studied 482 consecutive patients (age 78.8±6.7 years) admitted with stroke. Stroke was assessed at admission National Institutes of Health Scale ( NIHSS ). The outcome rates adverse (modified Rankin scale discharge ≥2). Independent predictors severe ≥16) were female sex atrial fibrillation. Treatment diuretics associated nonsevere At discharge,...
Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic in developed world. The pathogenesis NAFLD multifactorial, involving obesity, insulin resistance, inflammation and oxidative stress. Accordingly, several treatments targeting these pathways have been evaluated patients with but either shown limited efficacy or an unfavorable safety profile. On other hand, increased hepatocyte apoptosis also appears to be implicated development progression recent pilot studies suggest...