A5071942013- Traumatic Brain Injury Research
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Posttraumatic Stress Disorder Research
- Resilience and Mental Health
- Stress Responses and Cortisol
- Advanced Neuroimaging Techniques and Applications
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Anesthesia and Neurotoxicity Research
- Memory and Neural Mechanisms
- Identity, Memory, and Therapy
- Treatment of Major Depression
- Child and Adolescent Psychosocial and Emotional Development
- Tryptophan and brain disorders
- Migration, Health and Trauma
- Traumatic Brain Injury and Neurovascular Disturbances
- Sepsis Diagnosis and Treatment
- LGBTQ Health, Identity, and Policy
- Electrolyte and hormonal disorders
- COVID-19 and Mental Health
- Acupuncture Treatment Research Studies
- Mind wandering and attention
- Health and Conflict Studies
- Health and Well-being Studies
- Sexuality, Behavior, and Technology
Arq Psychotrauma Expert Group
2021-2025
Utrecht University
2017-2024
Maastricht University
2024
Ministry of Defence
2013-2023
McLean Hospital
2023
University Medical Center Utrecht
2012-2019
University Hospital Heidelberg
2012-2015
Heidelberg University
2012-2015
Ministry of Defence
2013-2014
Central Military Hospital
2012
Background Smaller hippocampal volume has often been observed in patients with post-traumatic stress disorder (PTSD). However, there is no consensus whether this a result of stress/trauma exposure, or constitutes vulnerability factor for the development PTSD. Second, it unclear normalizes successful treatment PTSD, smaller hippocampus risk persistence Method Magnetic resonance imaging (MRI) scans and clinical interviews were collected from 47 war veterans 25 healthy (combat controls)...
Post-traumatic stress disorder (PTSD) is an anxiety that associated with structural and functional alterations in several brain areas, including the anterior cingulate cortex (ACC).Here, we examine resting state connectivity of ACC subdivisions PTSD, using a seed-based approach.Resting magnetic resonance images were obtained from male veterans (n 5 31) without 25) healthy civilian controls 25).Veterans PTSD (combat controls) had reduced compared to between caudal precentral gyrus, perigenual...
Posttraumatic stress disorder (PTSD) is often associated with impaired fear inhibition and decreased safety cue processing; however, studies capturing the cognitive aspect of contextual processing are limited. In this fMRI study, role cues in response was investigated.Male medication-naive war veterans PTSD, male control (combat controls) healthy nonmilitary men (healthy underwent while performing stop-signal anticipation task (SSAT). The SSAT evokes 2 forms inhibition: reactive (outright...
Posttraumatic stress disorder (PTSD) is a disabling associated with resting state functional connectivity alterations. However, whether specific brain regions are altered in PTSD or the whole network organization differs remains unclear. can be treated trauma-focused therapy, although only half of patients recover after treatment. In order to better understand psychopathology our aim was study networks before and Resting magnetic resonance images were obtained from veterans (n = 50) controls...
Background Trauma-focused psychotherapy is treatment of choice for post-traumatic stress disorder (PTSD). However, about half patients do not respond. Recently, there increased interest in brain criticality, which assesses the phase transition between order and activity. Operating close to this borderline theorized facilitate optimal information processing. We studied if criticality related future response treatment, hypothesizing that responders’ brains function closer criticality. Methods...
Background Post-traumatic stress disorder (PTSD) is thought to be characterized by general heightened amygdala activation. However, this hypothesis mainly based on specific studies presenting fear or trauma-related stimuli, hence, a thorough investigation of trauma-unrelated emotional processing in PTSD needed. Methods In study, 31 male medication-naive veterans with PTSD, 28 control (combat controls; CC) and 25 non-military men (healthy HC) were included. Participants underwent functional...
Abstract Trauma-focused psychotherapy is the first-line treatment for posttraumatic stress disorder (PTSD) but 30–50% of patients do not benefit sufficiently. We investigated whether structural and resting-state functional magnetic resonance imaging (MRI/rs-fMRI) data could distinguish between responders non-responders on group individual level. Forty-four male veterans with PTSD underwent baseline scanning followed by trauma-focused psychotherapy. Voxel-wise gray matter volumes were...
Recent advances in data-driven computational approaches have been helpful devising tools to objectively diagnose psychiatric disorders. However, current machine learning studies limited small homogeneous samples, different methodologies, and imaging collection protocols, limit the ability directly compare generalize their results. Here we aimed classify individuals with PTSD versus controls assess generalizability using a large heterogeneous brain datasets from ENIGMA-PGC Working group. We...
Posttraumatic stress disorder (PTSD) is an anxiety that often diagnosed with comorbid depressive disorder. Therefore, neuroimaging studies investigating PTSD typically include both patients and without depression. Differences in activity of the anterior cingulate cortex (ACC) insula have been shown to differentiate major (MDD). Whether or not MDD affects resting state functional connectivity has investigated our knowledge. Here, (PTSD+MDD; n=27) (PTSD-MDD; n=23) was investigated. The...
Posttraumatic stress disorder (PTSD) can be treated with trauma-focused therapy, although only about 50% of the patients recover on short-term. In order to improve response rates it is important identify who will and not from therapy. Although previous studies reported dorsal anterior cingulate cortex (ACC) activity, as well cingulum bundle white matter microstructure integrity markers for persistence PTSD symptoms short-term, remains unclear whether these also predict long-term symptom...
Notorious for degrading diffusion MRI data quality are so-called susceptibility-induced off-resonance fields, which cause non-linear geometric image deformations. While acquiring additional to correct these distortions alleviates the adverse effects of this artifact drastically – e.g., by reversing polarity phase-encoding (PE) direction strategy is often not an option due scan time constraints. Especially in a clinical context, where patient comfort and safety paramount importance,...
<ns4:p>Posttraumatic stress disorder (PTSD) is an anxiety that often diagnosed with comorbid depressive disorder. Therefore, neuroimaging studies investigating PTSD typically include both patients and without depression. Differences in activity of the anterior cingulate cortex (ACC) insula have been shown to differentiate major (MDD). Whether or not MDD affects resting state functional connectivity has investigated our knowledge. Here, (PTSD+MDD; n=27) (PTSD-MDD; n=23) was investigated. The...
Although current treatments for Post-Traumatic Stress Disorder (PTSD) in war veterans are effective, unfortunately 30-50% still do not benefit from these treatments. Trauma-focused therapies, eg exposure therapy, primarily based on extinction processes which the endocannabinoid system (ECS) plays a significant role. Therefore, it can be hypothesized that poor treatment response trauma-focused therapy due to deficits may associated with poorly functioning ECS. The present study examined...