- Posttraumatic Stress Disorder Research
- Personality Disorders and Psychopathology
- Child Abuse and Trauma
- Psychotherapy Techniques and Applications
- Traumatic Brain Injury Research
- Stress Responses and Cortisol
- Anesthesia and Neurotoxicity Research
- Child and Adolescent Psychosocial and Emotional Development
- Migration, Health and Trauma
- Psychosomatic Disorders and Their Treatments
- Suicide and Self-Harm Studies
- Educational and Psychological Assessments
- Psychiatric care and mental health services
- Mental Health Research Topics
- Memory and Neural Mechanisms
- Identity, Memory, and Therapy
- Resilience and Mental Health
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Family Support in Illness
- Psychology of Development and Education
- Education, sociology, and vocational training
- Tryptophan and brain disorders
- Psychological Treatments and Assessments
- Attachment and Relationship Dynamics
- Grief, Bereavement, and Mental Health
Arkin
2020-2025
Amsterdam University Medical Centers
2020-2025
Reinier van Arkel
2020-2025
University of Amsterdam
2020-2024
Amsterdam Neuroscience
2012-2024
Vrije Universiteit Amsterdam
2011-2023
Amsterdam UMC Location Vrije Universiteit Amsterdam
2008-2021
Foundation Centrum '45
2021
Amsterdam UMC Location University of Amsterdam
2021
Center for Neurosciences
2017-2020
Article AbstractObjective: Classic posttraumatic stress disorder (PTSD) is associated with smaller hippocampus, amygdala, and anterior cingulate cortex (ACC) volumes. We investigated whether child abuse-related complex PTSD—a severe form of PTSD affect dysregulation high comorbidity—showed similar brain volume reductions. Method: used voxel-based morphometry to measure gray matter concentrations in referred outpatients (n = 31) compared matched healthy nontraumatized controls 28). Complex...
Post-traumatic stress disorder (PTSD) is associated with impaired memory performance coupled functional changes in brain areas involved declarative and emotion regulation. It not yet clear how symptom severity comorbidity affect neurocognitive functioning PTSD. We performed a magnetic resonance imaging (fMRI) study an emotional task 28 Complex PTSD patients comorbid depressive personality disorders, 21 healthy non-trauma-exposed controls. In patients—compared to controls—encoding of later...
Background Functional neuroimaging studies have shown increased Stroop interference coupled with altered anterior cingulate cortex (ACC) and insula activation in post-traumatic stress disorder (PTSD). These brain areas are associated error detection emotional arousal. There is some evidence that treatment can normalize these patterns. Method At baseline, we compared classic performance blood oxygenation level-dependent responses (functional magnetic resonance imaging) of 29 child...
<b><i>Background:</i></b> Evidence-based treatments for complex posttraumatic stress disorder (PTSD) related to childhood abuse are scarce. This is the first randomized controlled trial test efficacy of psycho-educational and cognitive behavioural stabilizing group treatment in terms both PTSD symptom severity. <b><i>Methods:</i></b> Seventy-one patients with severe comorbidity (e.g. 74% axis II comorbidity) were randomly assigned either a...
Predicting treatment efficacy in psychiatric disorders remains challenging, despite the availability of effective interventions. Previous studies suggest a link between brain network topology and individual disorders, but cross-disorder investigations are lacking. We analyzed pre-treatment MRI data from 177 individuals (113 females) with either obsessive-compulsive disorder (OCD) or post-traumatic stress comorbid personality (PTSD) that received different non-pharmacological treatments....
Background: Parental post-traumatic stress disorder (PTSD) can impact parenting and child psychosocial wellbeing. Complementing trauma-focused psychotherapy with interventions thus have important preventive value. Understanding parents' lived experiences is necessary to tailor such their needs.
Introduction: Comorbidity between posttraumatic stress disorder (PTSD) and borderline personality (BPD) is prevalent. Despite evidence-based therapies, high rates of non-response dropout persist. This study therefore aimed to examine whether the concurrent application eye movement desensitization reprocessing (EMDR) for PTSD dialectical behavior therapy (DBT) BPD yields better results than EMDR alone. Methods: Patients with a diagnosis at least four symptoms were randomly assigned (n = 63)...
BackgroundEye movement desensitization and reprocessing (EMDR) is an effective treatment for posttraumatic stress disorder (PTSD). During EMDR, the patient recalls traumatic memories while making eye movements (EMs). Making EMs during recall associated with decreased vividness emotionality of memories, but underlying mechanism has been unclear. Recent studies support a “working-memory” (WM) theory, which states that two tasks (recall EMs) compete limited capacity WM resources. However, prior...
Abstract Background Comorbidity between Posttraumatic Stress Disorder (PTSD) and Borderline Personality (BPD) is high. There growing motivation among clinicians to offer PTSD treatments – such as Eye Movement Desensitization Reprocessing (EMDR) - patients with comorbid BPD. However, a large subgroup BPD does not sufficiently respond treatment more likely be excluded or dropout from treatment. Dialectical Behaviour Therapy (DBT) for well established although there some evidence that DBT...
A general clinical assumption states that cluster B personality disorders (PDs) represent a more severe form of PD than C PDs. Consequently, most research is centered on PDs (especially borderline PD). Yet, prevalence ratings exceed those In this explorative, cross-sectional study, we compared and patients (N = 94) wide range clinically-relevant severity measures, including comorbidity, suicidality, (childhood) traumatization global functioning. Results showed that, although suffered often...
BackgroundIn the empirical and clinical literature, complex posttraumatic stress disorder (PTSD) personality disorders (PDs) are suggested to be predictive of drop-out or reduced treatment effectiveness in trauma-focused PTSD treatment.ObjectiveIn this study, we aimed investigate if characteristics would predict compliance stabilizing treatment.MethodIn a randomized controlled trial on 20-week group cognitive behavioral (CBT) for child-abuse-related PTSD, included 71 patients whom 38 were...
Comorbidity between posttraumatic stress disorder (PTSD) and borderline personality (BPD) is surrounded by diagnostic controversy although various effective treatments exist, dropout nonresponse are high.
Background: Posttraumatic stress disorder (PTSD) is associated with high rates of cluster C personality disorders (PD), which may negatively affect PTSD treatment. It unknown whether concurrent treatment for and comorbid PD leads to superior effects, compared standard trauma-focused
Attachment (mal)functioning and a history of childhood trauma (CT) are both considered psychological determinants personality disorders (PDs). Their interaction, however, remains largely uninvestigated. In this study, the authors assessed adult attachment style in sample patients with diverse PDs (N = 75) determined relation occurrence severity CT. The found that was characterized by severe malfunctioning high levels Using cross-tabulations analysis variance, showed fearful or dismissive...
Abstract Background Children of parents with post-traumatic stress disorder (PTSD) are at increased risk adverse psychological outcomes. An important mechanism is impaired parental functioning, including negative parenting behavior, perceived incompetence, and lack social support. Several interventions for trauma-exposed psychiatric disorders exist, but none have specifically targeted PTSD. Our objective to evaluate the effectiveness a blended care preventive intervention Methods The was...