A5008827987- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Posttraumatic Stress Disorder Research
- Heart Rate Variability and Autonomic Control
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- Blood Pressure and Hypertension Studies
- Medical Image Segmentation Techniques
- Child and Adolescent Psychosocial and Emotional Development
- EEG and Brain-Computer Interfaces
- Literature and Cultural Memory
- Neuropeptides and Animal Physiology
- Cardiovascular Health and Disease Prevention
- Memory Processes and Influences
- Neural dynamics and brain function
- Historical, Literary, and Cultural Studies
- Anesthesia and Neurotoxicity Research
- Traumatic Brain Injury Research
- Neurotransmitter Receptor Influence on Behavior
- Memory, History, Trauma, Identity
- Mental Health Research Topics
- Neural and Behavioral Psychology Studies
Central Institute of Mental Health
2015-2023
Heidelberg University
2013-2023
University Hospital Heidelberg
2013-2023
University Medical Centre Mannheim
2015
Posttraumatic stress disorder (PTSD) is a frequent anxiety with higher prevalence rates in female patients than male (2.5:1). Association single nucleotide polymorphism (rs2267735) the gene ADCYAP1R1 encoding type I receptor (PAC1-R) of pituitary adenylate cyclase activating polypeptide has been reported PTSD patients. We sought to identify neural correlates described PAC1-R effects on associative learning.In reverse genetic approach, we examined two independent healthy samples (N1 = 112, N2...
Understanding the association between autonomic nervous system [ANS] function and brain morphology across lifespan provides important insights into neurovisceral mechanisms underlying health disease. Resting-state ANS activity, indexed by measures of heart rate [HR] its variability [HRV] has been associated with morphology, particularly cortical thickness [CT]. While findings have mixed regarding anatomical distribution direction associations, these inconsistencies may be due to sex age...
Differences in structural white and gray matter survivors of traumatic experiences have been related to the development maintenance Posttraumatic Stress Disorder (PTSD). However, there are very few studies on diffusion tensor imaging region based morphometry comparing patients with PTSD two control groups, namely healthy individuals or without trauma experience. It is also unknown if differences associated. In this cross-sectional study, we examined white- between 44 PTSD, 49 61 subjects. We...
Deficiency in contextual and enhanced responding cued fear learning may contribute to the development of posttraumatic stress disorder (PTSD). We examined responses aversive Pavlovian conditioning with an unpredictable spatial context as conditioned stimulus compared a predictable context. hypothesized that PTSD group would demonstrate less hippocampal ventromedial prefrontal cortex (vmPFC) activation during acquisition extinction contexts over-reactive amygdala response controls.A novel...
Understanding the association between autonomic nervous system [ANS] function and brain morphology across lifespan provides important insights into neurovisceral mechanisms underlying health disease. Resting state ANS activity, indexed by measures of heart rate [HR] its variability [HRV] has been associated with morphology, particularly cortical thickness [CT]. While findings have mixed regarding anatomical distribution direction associations, these inconsistencies may be due to sex age...
Abstract Background Deficiency in contextual and enhanced responding cued fear learning may contribute to the development of posttraumatic stress disorder (PTSD). We examined responses aversive Pavlovian conditioning with an unpredictable spatial context as conditioned stimulus compared a predictable context. hypothesized that PTSD group would depict less hippocampal ventromedial prefrontal cortex (vmPFC) activation during acquisition extinction contexts overreactive amygdala response...