A5052849134- Heart Rate Variability and Autonomic Control
- Functional Brain Connectivity Studies
- Pain Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Cardiovascular Syncope and Autonomic Disorders
- Mental Health Research Topics
- Neural dynamics and brain function
- Pain Management and Placebo Effect
- Cardiac electrophysiology and arrhythmias
- Psychosomatic Disorders and Their Treatments
- Non-Invasive Vital Sign Monitoring
- Eating Disorders and Behaviors
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cardiac Health and Mental Health
- ECG Monitoring and Analysis
- Advanced Neuroimaging Techniques and Applications
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Musculoskeletal pain and rehabilitation
- Blood Pressure and Hypertension Studies
- Neural and Behavioral Psychology Studies
- Neuroscience of respiration and sleep
- Treatment of Major Depression
- Cardiovascular and exercise physiology
- Schizophrenia research and treatment
- Thermoregulation and physiological responses
Jena University Hospital
2016-2025
University of Tulsa
2024
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2010-2022
University of Zurich
2022
Amt für Umwelt
2022
Brain (Germany)
2018-2020
Friedrich Schiller University Jena
2009-2018
Technische Universität Ilmenau
2015
Center for Clinical Studies
2012
Ruhr University Bochum
2009-2011
One frequently described feature of depression is an increased vulnerability to pain complaints, and chronic accompanied by symptoms depression. In contrast this, a decreased sensitivity experimental has been in major The physiological basis this phenomenon yet elusive. We investigated 30 patients suffering from depressive disorder matched controls. Pain testing (threshold tolerance) was performed on both sides the body included assessment thermal, electrical ischemic pain. While confirming...
To investigate cardiac autonomic dysfunction in patients with major depressive disorder (MDD). Research this area has faced several limitations because of the heterogeneity disease, influence medication, and methodological shortcomings.Participants were 75 suffering from an acute recurrent episode MDD matched controls. All participants assessed at baseline for linear nonlinear parameters heart rate variability, QT variability baroreflex sensitivity. Participants reassessed after 7 to 9 days...
The brainstem is of tremendous importance for our daily survival, and yet the functional relationships between various nuclei, their projection targets, afferent regulatory areas remain poorly characterized. main reason this lies in sub-optimal performance standard neuroimaging methods area. In particular, fMRI signals are much harder to detect region compared cortical areas. Here we describe validate a new approach measure activation nuclei humans using sequences widely available tools...
Heart rate variability (HRV) biofeedback has a beneficial impact on perceived stress and emotion regulation. However, its brain function is still unclear. In this study, we aimed to investigate the effect of an 8-week HRV-biofeedback intervention functional connectivity in healthy subjects.HRV was carried out five sessions per week, including four at home one our lab. A control group played jump'n'run games instead training. Functional magnetic resonance imaging conducted before after both...
Prostaglandins (PGs) are local mediators of several functions in the CNS. Both primary afferent neurons and intrinsic cells spinal cord produce PGs, with a marked upregulation during peripheral inflammation. Therefore, significance PGs neuronal processing mechanosensory information was herein investigated. In anesthetized rats, discharges nociceptive input from knee joint were extracellularly recorded. Topical administration prostaglandin E(2) (PGE(2)) to facilitated expanded receptive field...
Major depressive disorders (MDD) are associated with an increased risk for cardiovascular morbidity and mortality. Even if it is known that MDD accompanied by autonomic dysbalance sympathetic and/or reduced parasympathetic activity, to date only limited information available about the degree complexity of regulation. The aim this study was investigate influence on autonomous nervous system means linear nonlinear indices from heart rate blood pressure variability (HRV, BPV). From 57...
Abstract Purpose To determine alterations in the retina of patients with Alzheimer's disease ( AD ) by newly developed technique fluorescence lifetime imaging ophthalmoscopy FLIO a pilot study. Methods set‐up uses scanning laser ophthalmoscope HRA 2, Heidelberg Engineering, Germany), which was modified use an excitation pulse BLD 440 (Becker&Hickl, Berlin, Germany) and detection time‐correlated single photon counting TCSPC ; Becker&Hickl) two spectral channels (channel 1: 490–560 nm,...
Abstract The hippocampus (HPC) is functionally heterogeneous along the longitudinal anterior–posterior axis. In rodent models, gene expression maps define at least three discrete subregions, which also differ in function, and anatomical connectivity with rest of brain. humans, equivalent HPC subregions are less well defined, resulting a lack consensus neuroimaging approaches that limits translational study. This study determined whether data‐driven analysis, namely independent component...
The dysfunction of specific brain areas might account for the distortion body image in patients with anorexia nervosa. present study was designed to reveal regions that are abnormal structure and function this disorder. We hypothesized, based on altered activity nervosa involved pain processing, an interrelation structural aberrations frontoparietal-cingulate network aberrant functional activation during thermal processing disorder.We determined thresholds outside MRI scanner matched healthy...
Previous functional magnetic resonance imaging (fMRI) studies demonstrated an abnormally coordinated network functioning in Major Depression Disorder (MDD) during rest. The main monoamine-producing nuclei within midbrain/brainstem are functionally integrated these specific networks. Therefore, we aimed to investigate the resting-state connectivity (RSFC) of 45 MDD patients and differences between receiving two different classes antidepressant drugs. Patients showed reduced RSFC from ventral...
Abstract The transition from suicidal ideas to a suicide act is an important topic of research for the identification those patients at risk acting out. We investigated here whether specific brain activity and connectivity measures rest may be differently associated with thoughts behaviors. A large sample acutely depressed major depressive disorder was recruited in three different centers (Montreal/Canada, Stanford/USA, Jena/Germany), covering four phenotypes: past history attempt ( n = 53),...
Abstract Autonomic regulation of blood pressure and cardiac rhythm progressively declines with increasing age. Impaired cardiovascular control promotes a variety age-related cardio-vascular conditions. This study aims to provide database high-resolution biological signals describe the effect healthy aging on regulation. Electrocardiogram continuous non-invasive were recorded simultaneously at rest in 1,121 volunteers. With this database, we raw as well basic demographic information such...