A5089960296- Pain Mechanisms and Treatments
- Heart Rate Variability and Autonomic Control
- Cardiovascular Syncope and Autonomic Disorders
- Functional Brain Connectivity Studies
- Glaucoma and retinal disorders
- Pain Management and Placebo Effect
- Neuropeptides and Animal Physiology
- Alcoholism and Thiamine Deficiency
- Cardiac electrophysiology and arrhythmias
- Pharmacological Effects of Natural Compounds
- Retinal Development and Disorders
- Peripheral Neuropathies and Disorders
- Retinal Diseases and Treatments
- EEG and Brain-Computer Interfaces
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Treatment of Major Depression
- Osteoarthritis Treatment and Mechanisms
- Cardiac Health and Mental Health
- Hemophilia Treatment and Research
- Blood Pressure and Hypertension Studies
- Stress Responses and Cortisol
- Olfactory and Sensory Function Studies
- Nerve injury and regeneration
- ECG Monitoring and Analysis
Bayer (Germany)
2011-2024
Witten/Herdecke University
2022-2023
University of Wuppertal
2013-2018
Jena University Hospital
2008-2016
Friedrich Schiller University Jena
2005-2015
Bayer (United States)
2015
University of Würzburg
2007-2010
Czech Academy of Sciences, Institute of Physiology
2010
Zero to Three
2009
University Hospital Leipzig
2007
Abstract This study aimed to validate a wearable device’s walking speed estimation pipeline, considering complexity, speed, and bout duration. The goal was provide recommendations on the use of devices for real-world mobility analysis. Participants with Parkinson’s Disease, Multiple Sclerosis, Proximal Femoral Fracture, Chronic Obstructive Pulmonary Congestive Heart Failure, healthy older adults (n = 97) were monitored in laboratory (2.5 h), using lower back device. Two pipelines validated...
One frequently described feature of depression is an increased vulnerability to pain complaints, and chronic accompanied by symptoms depression. In contrast this, a decreased sensitivity experimental has been in major The physiological basis this phenomenon yet elusive. We investigated 30 patients suffering from depressive disorder matched controls. Pain testing (threshold tolerance) was performed on both sides the body included assessment thermal, electrical ischemic pain. While confirming...
To investigate cardiac autonomic dysfunction in patients with major depressive disorder (MDD). Research this area has faced several limitations because of the heterogeneity disease, influence medication, and methodological shortcomings.Participants were 75 suffering from an acute recurrent episode MDD matched controls. All participants assessed at baseline for linear nonlinear parameters heart rate variability, QT variability baroreflex sensitivity. Participants reassessed after 7 to 9 days...
Synaptic inhibition is a central factor in the fine tuning of neuronal activity nervous system. Symptoms consistent with reduced such as stiffness, spasms and anxiety occur paraneoplastic stiff person syndrome autoantibodies against intracellular synaptic protein amphiphysin. Here we show that intrathecal application purified anti-amphiphysin immunoglobulin G antibodies induces syndrome-like symptoms rats, including stiffness muscle spasms. Using vivo recordings Hoffmann reflexes dorsal root...
The reduction of pain in the course antiinflammatory therapy can result from an attenuation inflammatory process and/or neutralization endogenous mediators inflammation that act directly on nociceptive neurons. purpose this study was to investigate whether analgesic effects tumor necrosis factor alpha (TNFalpha) are due or direct neuronal significantly contribute relief therapy.Locomotor and pain-related behavior histology were assessed rats with chronic antigen-induced arthritis (AIA) knee...
Withdrawal from analgesic and addictive substances such as opioids or ethanol is associated with increased sensitivity to sensory stimulation in animal models. Here, we investigated perception of innocuous noxious thermal electric stimuli applied the left hand sternum 30 male patients undergoing withdrawal alcohol, abstained alcoholics matched controls. The alcohol scale Banger score were obtained estimate severity withdrawal. In addition, Beck depression inventory was used influence...
After peripheral nerve damage macrophages infiltrate the dorsal root ganglia (DRG) in which cell bodies of lesioned neurons are located. However, infiltration into DRGs was also reported complete Freund's adjuvant (CFA)-induced inflammation raising question whether CFA induces or may trigger macrophage DRGs. Related questions are, first, signals and, second, is correlated with pain-related behavior. Using rat model unilateral antigen-induced arthritis (AIA) knee we found a massive ED1+ ipsi-...
Background: Although it has been largely demonstrated that nitric oxide synthase (NOS), a key enzyme for (NO) production, modulates inflammatory pain, the molecular mechanisms underlying these effects remain to be clarified. Here we asked whether cytokines, which have well-described roles in are downstream targets of NO pain and isoforms NOS involved this process. Results: Intraperitoneal (i.p.) pretreatment with 7-nitroindazole sodium salt (7-NINA, selective neuronal inhibitor),...
Calcium-activated potassium ion channels SK and IK (small intermediate conductance, respectively) may be important in the pathophysiology of pain following nerve injury, as are known to impose a period reduced excitability after each action potential by afterhyperpolarization. We studied presence changes human SK1 (hSK1)- hIK1-like immunoreactivity control injured dorsal root ganglia (DRG) peripheral nerves their regulation key neurotrophic factors cultured rat sensory neurones. Using...
To assess the relative importance of isoforms nitric oxide synthase (NOS) in inflammatory pain, we directly compared pain behaviour and paw thickness after intraplantar injection complete Freund's adjuvant (CFA) wild-type (WT) mice lacking either inducible (iNOS), endothelial (eNOS) or neuronal NOS (nNOS). In deficient for nNOS, thermal hyperalgesia was reduced by approximately 50% to wild type at 4 8h CFA injection, mechanical hypersensitivity absent. The only change iNOS eNOS WT a more...
Decreased vagal activity has been described in acute schizophrenia and might be associated with altered cardiovascular regulation increased cardiac mortality. The aim of this study was to assess baroreflex sensitivity the context psychopathology. Twenty-one acute, psychotic, unmedicated patients a diagnosis paranoid were investigated after admission hospital. Results compared 21 healthy volunteers matched respect age sex. Cardiovascular parameters obtained included measures for heart rate...
Recent studies revealed cardiac autonomic dysfunction in patients with acute schizophrenia, which appears to be mainly related reduced vagal and increased sympathetic modulation. To understand the significance of function we extended these relatives patients. In this study, assessed modulation healthy first-degree schizophrenia (n = 36) investigate a putative genetic influence. Data were compared control subjects matched for age, gender, physical activity as well suffering from...
In addition to the sensitization of pain fibers in inflamed tissues, increased excitability spinal cord is an important mechanism inflammatory pain. Furthermore, neuronal has been suggested play a role modulating peripheral inflammation. This study was undertaken test hypothesis that actions proinflammatory cytokine tumor necrosis factor alpha (TNFalpha) add significantly both hyperalgesia and maintenance inflammation.Rats with antigen-induced arthritis (AIA) were treated intrathecally...
<b>Objective:</b> To determine if submaximal contractions used in contract-relax proprioceptive neuromuscular facilitation (CRPNF) stretching of the hamstrings yield comparable gains hamstring flexibility to maximal voluntary isometric (MVICs). <b>Method:</b> Randomised controlled trial. A convenience sample 72 male subjects aged 18–27 was used. Subjects qualified by demonstrating tight hamstrings, defined as inability reach 70° hip flexion during a straight leg raise. Sixty were randomly...
Summary People with hemophilia show a clinical severity-related decrease in mechanical pain thresholds affected joints, but cope rather well their chronic pain. Recurrent joint bleedings people (PWH) often progress into the full picture of hemophilic arthropathy, accompanied by Although is commonly present PWH, investigations assessing have not been performed yet. Thus, aim this study was to obtain objective and subjective measures PWH relate these severity pathology. Thirty-six patients...
The pain mediator prostaglandin E 2 (PGE ) sensitizes nociceptive pathways through EP2 and EP4 receptors, which are coupled to G s proteins increase cAMP. However, PGE also activates EP3 the major signaling pathway of receptor splice variants uses inhibition cAMP synthesis via i proteins. This opposite effect raises intriguing question whether -protein–coupled may counteract receptor-mediated pronociceptive effects . We found extensive localization in primary sensory neurons spinal cord....
Background and Purpose— Recent reports suggest that vascular factors play a crucial role in the development progression of Alzheimer’s disease. We aimed to assess vasomotor reactivity patients with disease dementia due microangiopathy using transcranial Doppler sonography near-infrared spectroscopy during CO 2 exposition task. Methods— The normalized assessed at middle cerebral artery oxygenated deoxygenated hemoglobin frontal cortex were obtained. To investigate impact cholinergic...