A5063458011- Functional Brain Connectivity Studies
- Eating Disorders and Behaviors
- Heart Rate Variability and Autonomic Control
- Psychosomatic Disorders and Their Treatments
- Neural and Behavioral Psychology Studies
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Mental Health Research Topics
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Pain Management and Placebo Effect
- Body Image and Dysmorphia Studies
- Blood Pressure and Hypertension Studies
- Neurogenesis and neuroplasticity mechanisms
- Non-Invasive Vital Sign Monitoring
- Neuroscience and Neuropharmacology Research
- Attention Deficit Hyperactivity Disorder
- Evolutionary Psychology and Human Behavior
- Stress Responses and Cortisol
- Human Mobility and Location-Based Analysis
- Hair Growth and Disorders
- Lightning and Electromagnetic Phenomena
- Medical and Biological Ozone Research
Jena University Hospital
2016-2025
University of Tulsa
2024
Friedrich Schiller University Jena
2016
Ministerio de Ciencia, Tecnología y Medio Ambiente
2013
Heart rate variability (HRV) biofeedback has a beneficial impact on perceived stress and emotion regulation. However, its brain function is still unclear. In this study, we aimed to investigate the effect of an 8-week HRV-biofeedback intervention functional connectivity in healthy subjects.HRV was carried out five sessions per week, including four at home one our lab. A control group played jump'n'run games instead training. Functional magnetic resonance imaging conducted before after both...
The dysfunction of specific brain areas might account for the distortion body image in patients with anorexia nervosa. present study was designed to reveal regions that are abnormal structure and function this disorder. We hypothesized, based on altered activity nervosa involved pain processing, an interrelation structural aberrations frontoparietal-cingulate network aberrant functional activation during thermal processing disorder.We determined thresholds outside MRI scanner matched healthy...
Previous functional magnetic resonance imaging (fMRI) studies demonstrated an abnormally coordinated network functioning in Major Depression Disorder (MDD) during rest. The main monoamine-producing nuclei within midbrain/brainstem are functionally integrated these specific networks. Therefore, we aimed to investigate the resting-state connectivity (RSFC) of 45 MDD patients and differences between receiving two different classes antidepressant drugs. Patients showed reduced RSFC from ventral...
Interventional studies suggest that changes in physical fitness affect brain function and structure. We studied the influence of high intensity exercise on hippocampal volume metabolism 17 young healthy male adults during a 6-week program compared with matched controls. further aimed to relate these hypothesized exercised-induced brain-derived neurotrophic factor (BDNF), interleukin-6 (IL-6), tumor necrosis alpha (TNF-α). show profound improvement most subjects positive correlation between...
Understanding the association between autonomic nervous system [ANS] function and brain morphology across lifespan provides important insights into neurovisceral mechanisms underlying health disease. Resting-state ANS activity, indexed by measures of heart rate [HR] its variability [HRV] has been associated with morphology, particularly cortical thickness [CT]. While findings have mixed regarding anatomical distribution direction associations, these inconsistencies may be due to sex age...
ABSTRACT The human brain possesses a unique ability to switch between patterns of functional connectivity, known as states, which are crucial for regulating biological, cognitive, and emotional processes. These states linked numerous neurological neuropsychiatric conditions, however, their relationship clinical symptoms anorexia nervosa (AN) is not well understood. In this exploratory study, we aimed identify whole‐brain dynamic alterations in AN association with symptoms. To end, recruited...
<title>Abstract</title> Anorexia nervosa (AN) is linked to changes in autonomic function, but the specific neuroanatomical substrates of these are not well understood. In this study, we used diffusion-weighted imaging examine white matter structure ventromedial prefrontal cortex–dorsal vagal complex (vmPFC-DVC) pathway, which essential for regulation. Compared healthy controls, individuals with AN showed significantly higher fractional anisotropy and axial diffusivity, as more streamlines...
Inhibition mechanisms are essential in daily life, helping individuals adapt to environmental demands. However, the causal interactions between large-scale functional networks involved response inhibition remain poorly understood. In this study, we examined effective connectivity (EC) underlying inhibitory processes brain using dynamic modeling (DCM) and independent component analysis (ICA). We conducted a Go-NoGo fMRI task with 19 healthy participants investigate these networks. Our results...
Interactions between top-down attention and bottom-up visceral inputs are assumed to produce conscious perceptions of interoceptive states, while each process has been independently associated with aberrant symptomatology in psychiatric disorders, the neural substrates this interface unknown. We conducted a preregistered functional neuroimaging study 46 individuals anxiety, depression, and/or eating disorders (ADE) propensity-matched healthy comparisons (HC), comparing their activity across...
Abstract Understanding the neural mechanisms of suicidal behavior is crucial. While regional brain alterations have previously been reported, knowledge about functional connectomics currently limited. Here, we investigated differences in global topologic network properties and local network-based organization both suicide attempters relatives. Two independent samples depressed (N = 42), patient controls 43), healthy 66) as well one sample relatives victims 16) patients were with magnetic...
Abstract Structural brain abnormalities are a consistent finding in anorexia nervosa (AN) and proposed as state biomarker of the disorder. Yet little is known about how regional structural changes affect intrinsic resting-state functional connectivity (rsFC). Using cross-sectional, multimodal imaging approach, we investigated association between cortical thickness rsFC AN. Twenty-two acute AN patients twenty-six age- gender-matched healthy controls underwent magnetic resonance scan cognitive...
Precise knowledge of the mechanisms that coordinate work and energy supply brain, so called neurovascular coupling, is fundamental for understanding brain energetics, but also interpretation imaging signals obtained in techniques such as functional magnetic resonance (fMRI). Interactions between neuronal activity cerebral blood flow regulation are largely compartmentalized. First, there exists a specialization where glutamatergic peri-synaptic its electrophysiological events linked to...
Regular physical exercise leads to increased vagal modulation of the cardiovascular system. A combination peripheral and central processes has been proposed underlie this adaptation. However, specific changes in autonomic network have not described human more detail. We hypothesized that anterior hippocampus known be influenced by regular activity might involved development after a 6 weeks high intensity intervention young healthy men (exercise group: n = 17, control 17). In addition...
Abstract Recent functional magnetic resonance imaging (fMRI) studies showed that blood oxygenation level‐dependent (BOLD) signal fluctuations in the default mode network (DMN) are functionally tightly connected to those monoaminergic nuclei, producing dopamine (DA), and serotonin (5‐HT) transmitters, midbrain/brainstem. We combined accelerated fMRI acquisition with spectral Granger causality coherence analysis investigate causal relationships between these areas. Both methods independently...
Anorexia nervosa (AN) is characterized by low body weight, disturbed eating, image disturbance, anxiety, and interoceptive dysfunction. However, the neural processes underlying these dysfunctions in AN are unclear. This investigation combined an pharmacological probe, peripheral β-adrenergic agonist isoproterenol, with resting-state functional magnetic resonance imaging to examine whether individuals relative healthy comparison participants show dysregulated coupling central autonomic...
Previous research on central nervous serotonin (5-HT) function provided evidence for a substantial involvement of 5-HT in the regulation brain circuitries associated with cognitive and affective processing. The underlying neural networks comprise core subcortical/cortical regions such as amygdala medial prefrontal cortex, which are assumed to be modulated amongst others by 5-HT. Beside use antidepressants, acute tryptophan depletion (ATD) is widely accepted technique manipulate synthesis its...
Introduction Autism spectrum disorder (ASD) is a neurodevelopmental that persists into adulthood with both social and cognitive disturbances. Asperger's syndrome (AS) was distinguished subcategory of autism in the DSM-IV-TR defined by specific symptoms including difficulties interactions, inflexible thinking patterns, repetitive behaviour without any delay language or development. Studying functional brain organization individuals these may help to better understand symptoms. Methods The aim...