A5067937717- Heart Rate Variability and Autonomic Control
- Functional Brain Connectivity Studies
- Multisensory perception and integration
- Dementia and Cognitive Impairment Research
- Pain Mechanisms and Treatments
- Neural and Behavioral Psychology Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Advanced MRI Techniques and Applications
- Stress Responses and Cortisol
- Color perception and design
- Olfactory and Sensory Function Studies
- Neurobiology of Language and Bilingualism
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Blood Pressure and Hypertension Studies
- Transcranial Magnetic Stimulation Studies
- Cognitive Functions and Memory
- Subtitles and Audiovisual Media
- Neural dynamics and brain function
- Pain Management and Treatment
- Parkinson's Disease Mechanisms and Treatments
- COVID-19 and Mental Health
- Fibromyalgia and Chronic Fatigue Syndrome Research
King's College London
2019-2025
St George's, University of London
2024
Wellcome Centre for Human Neuroimaging
2020-2021
Fondazione Santa Lucia
2013-2020
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2020
MRC Cognition and Brain Sciences Unit
2020
University of Cambridge
2020
Brighton and Sussex Medical School
2015-2016
University of Sussex
2015-2016
University of Edinburgh
2015
Despite the high prevalence of generalized anxiety disorder (GAD) and its negative impact on society, neurobiology remains obscure. This study characterizes neurostructural abnormalities associated with key symptoms GAD, focusing indicators impaired emotion regulation (excessive worry, poor concentration, low mindfulness, physiological arousal).These domains were assessed in 19 (16 women) GAD patients healthy controls matched for age gender, using questionnaires a demand behavioral task...
This longitudinal study investigates the modifications in structure and function occurring to typical Alzheimer's disease (AD) brains over a 2-year follow-up, from pre-dementia stages of disease, with aim identifying biomarkers prognostic value. Thirty-one patients amnestic mild cogn itive impairment were recruited followed-up clinical, neuropsychological, MRI assessments. Patients retrospectively classified as AD Converters or Non-Converters, data compared between groups. Cross-sectional at...
Myotonic dystrophy type 1 (DM1), the most common muscular observed in adults, is a genetic multisystem disorder affecting several other organs besides skeletal muscle, including brain. Cognitive and personality abnormalities have been reported; however, no studies investigated brain functional networks their relationship with traits/disorders patients DM1.To use resting-state magnetic resonance imaging to assess potential between changes connectivity within default mode network (DMN) DM1.We...
Understanding the association between autonomic nervous system [ANS] function and brain morphology across lifespan provides important insights into neurovisceral mechanisms underlying health disease. Resting-state ANS activity, indexed by measures of heart rate [HR] its variability [HRV] has been associated with morphology, particularly cortical thickness [CT]. While findings have mixed regarding anatomical distribution direction associations, these inconsistencies may be due to sex age...
Constructional apraxia (CA) is often, but not always, observed in patients with Alzheimer's disease (AD). CA usually explained by impairment of either basic perceptual and motor abilities, or executive functions. This study aims to evaluate the structural correlates AD. Forty-eight AD 20 healthy age-matched controls underwent a thorough neuropsychological investigation an MRI scan collect high-resolution T1-weighted data. Patients were classified as having (ADca) (ADnonca) based on...
Excessive and uncontrollable worry is a defining feature of Generalized Anxiety Disorder. An important endeavor in the treatment pathological to understand why some people are unable stop worrying once they have started. Worry perseveration associated with tendency deploy goal-directed rules (known as 'as many can' rules; AMA). These require attention goal task continuation until aims 'worry bout' achieved. This study examined association between use AMA neural autonomic responses...
Behavioral disorders and psychological symptoms (BPSD) in Alzheimer's disease (AD) are known to correlate with grey matter (GM) atrophy and, as shown recently, also white (WM) damage. WM damage its relationship GM reported AD, reinforcing the interpretation of AD pathology light a disconnection syndrome. It remains uncertain whether this might account for different BPSD observable AD. Here, we tested hypothesis patterns association between corpus callosum (CC) patients exhibiting one...
Functional neuroimaging techniques have provided great insight in the field of pain. Utilising these techniques, we characterised pain-induced responses brain and improved our understanding key pain-related phenomena. Despite utility methods, there remains a need to assess test retest reliability pain modulated blood-oxygen-level-dependant (BOLD) MR signal across repeated sessions. This is especially case for more novel yet increasingly implemented stimulation modalities, such as noxious...
Biallelic genetic mutations in the Park2 and PINK1 genes are frequent causes of autosomal recessive PD. Carriers single heterozygous may manifest subtle signs disease, thus providing a unique model preclinical One emerging hypothesis suggests that non-motor symptom PD, such as cognitive impairment be due to distributed functional disruption various neuronal circuits. Using resting-state MRI (RS-fMRI), we tested abnormal connectivity within between brain networks account for patients' status....
Patients with amnestic mild cognitive impairment (aMCI) have higher probability to develop Alzheimer's disease (AD) than elderly controls. The detection of subtle changes in brain structure associated progression and the development tools identify patients at high risk for dementia a short time is crucial. Here, we used probabilistic white matter (WM) tractography explore microstructural alterations within main association, limbic, commissural pathways aMCI who converted AD after 1 year...
Abstract Functional connectivity (FC) perturbations have been reported in multiple chronic pain phenotypes, but the nature of changes is varied and inconsistent between cohorts. Increases decreases strength task negative positive networks, for example, default mode salience networks (DMN/SN), respectively, described, how other are effected, descending control remains unknown. Whether relate to peripherally-mediated nociceptive afferent input, represent coping strategies or sequelae pain,...
Saccades operate a continuous selection between competing targets at different locations. This competition has been mostly investigated in the visual context, and it is well known that distractor can interfere with saccade toward target. Here, we whether multimodal, audio-visual confer stronger resilience against distraction. to had shorter latencies than saccades unisensory stimuli. facilitation exceeded level could be explained by simple probability summation, indicating multisensory...
Understanding the association between autonomic nervous system [ANS] function and brain morphology across lifespan provides important insights into neurovisceral mechanisms underlying health disease. Resting state ANS activity, indexed by measures of heart rate [HR] its variability [HRV] has been associated with morphology, particularly cortical thickness [CT]. While findings have mixed regarding anatomical distribution direction associations, these inconsistencies may be due to sex age...
Abstract There is a strict interaction between the autonomic nervous system (ANS) and pain, which might involve descending pain modulatory mechanisms. The periaqueductal grey (PAG) involved both in modulation ANS, but its role mediating this relationship has not yet been explored. Here, we sought to determine brain regions ANS control associations. 30 participants underwent Conditioned Pain Modulation (CPM) assessments, they rated painful pressure stimuli applied their thumbnail, either...
Abstract Due to its ability reflect the capacity engage in context-appropriate responses, tonic heart rate variability (HRV) is considered a putative biomarker of stress resilience. However, most studies are cross-sectional, precluding causal inferences. The high levels uncertainty and fear at global level that characterize COVID-19 pandemic offer unique opportunity investigate longitudinal role HRV present study examined whether HRV, measured about 2 years earlier (Time 0), could predict...