A5030771048- Dementia and Cognitive Impairment Research
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
- Neurobiology of Language and Bilingualism
- Functional Brain Connectivity Studies
- Memory Processes and Influences
- Spatial Neglect and Hemispheric Dysfunction
- Advanced Neuroimaging Techniques and Applications
- Neural and Behavioral Psychology Studies
- Neurological Disease Mechanisms and Treatments
- Cognitive Functions and Memory
- Neurological Disorders and Treatments
- Advanced MRI Techniques and Applications
- Action Observation and Synchronization
- Face Recognition and Perception
- Traumatic Brain Injury Research
- Language Development and Disorders
- Reading and Literacy Development
- Identity, Memory, and Therapy
- Spatial Cognition and Navigation
- Health, Environment, Cognitive Aging
- Child and Animal Learning Development
- Musculoskeletal pain and rehabilitation
- Frailty in Older Adults
- Parkinson's Disease Mechanisms and Treatments
Fondazione Santa Lucia
2014-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2010-2023
Cambridge University Press
2017
International Society of Nephrology
2017
University of Rome Tor Vergata
2011
Università Cattolica del Sacro Cuore
1994-2003
<i>Background/Aims:</i> Sleep disturbances are common in the elderly and persons with cognitive decline. The aim of this study was to describe frequency characteristics insomnia, excessive daytime sleepiness, sleep-disordered breathing, REM behavior disorder restless legs syndrome a large cohort mild impairment or dementia. <i>Methods:</i> 431 consecutive patients were enrolled 10 Italian neurological centers: 204 had Alzheimer’s disease, 138 impairment, 43 vascular...
<h3>Objective</h3> To assess the contribution of regional grey matter (GM) atrophy and functional disconnection in determining level cognitive decline patients with Alzheimer9s disease (AD) at different clinical stages. <h3>Methods</h3> Ten amnesic mild impairment (a-MCI), 11 probable AD 10 healthy controls were recruited. T1 volumes obtained from each subject postprocessed according to an optimised voxel based morphometry protocol. Resting state MRI data also collected same individuals...
This study investigates abnormalities of grey (GM) and white matter (WM) in Alzheimer's disease (AD), by modeling the AD pathological process as a continuous course between normal aging fully developed dementia, with amnesic mild cognitive impair
Objective The aim of this paper was to assess the efficacy process-based cognitive training (pb-CT) combined with reminiscence therapy (RT) in patients mild Alzheimer's disease (mAD) and impairment (MCI) healthy elderly (HE) subjects. Methods This multicenter, randomized, controlled trial involved 348 participants mAD, MCI, HE from four European countries. Participants were randomly assigned two arms a crossover design: those arm A underwent 3 months computerized pb-CT for memory executive...
Rates of disease progression differ among patients with Alzheimer's disease, but little is known about prognostic predictors. The aim the study was to assess whether sociodemographic factors, severity and duration, vascular factors are predictors cognitive decline in progression. We conducted a longitudinal clinical specialized unit for diagnosis treatment dementia Rome, Italy. A total 154 persons mild moderate consecutively admitted were included. All underwent extensive examination by...
Episodic long-term, short-term, and implicit memory were investigated in 79 elderly subjects who fulfilled criteria for the amnestic form of mild cognitive impairment (a-MCI; i.e., by having an idiopathic disorder with absence areas other than without confounding medical or psychiatric conditions) developed Alzheimer's disease (AD) after 2 years as well 111 affected a-MCI did not develop dementia. Results document a profile characterized preserved short-term extensive episodic long-term...
Behavioral and psychological symptoms of dementia (BPSD) are commonly observed over the course Alzheimer's disease (AD). However, it is unclear whether BPSD part AD neuropathology or rather represent a reaction to cognitive disabilities. Using voxel-based-morphometry (VBM), we aimed clarify this issue by investigating patients with at different clinical stages. Twenty-seven (12 early [ADe] 15 moderate [ADm]), 19 amnestic mild impairment (a-MCI), 23 healthy controls underwent MRI scanning 3T....
Abstract This study investigates the differential contribution of gray matter (GM) atrophy and deafferentation through white (WM) damage in clinical progression Alzheimer's disease (AD). Thirty‐one patients with probable AD, 23 amnestic mild cognitive impairment (a‐MCI), 14 healthy subjects underwent MRI scanning at 3T. Voxel‐based morphometry was used to assess regional GM AD a‐MCI patients. Diffusion tensor‐MRI tractography reconstruct cingulum bilaterally, quantify, voxel‐by‐voxel, its...
The aim of this study was to investigate the neuropsychological correlates behavioral and psychological symptoms (BPSD) in patients affected by various forms dementia, namely Alzheimer's disease (AD), frontal-variant frontotemporal dementia (fvFTD), Lewy body (LBD), subcortical ischemic vascular (SIVD). 21 fvFTD, LBD, 22 AD, SIVD matched for severity received a battery tests Neuropsychiatry Inventory (NPI). possible association between performance on BPSD assessed correlational analysis...
Cognitive reserve (CR), for which formal education represents a proxy index, has been claimed as factor mitigating the clinical manifestations of Alzheimer disease (AD). The aim this study was to assess impact in modifying relationship between cerebral grey matter (GM) damage and large cohort patients with AD or amnesic mild cognitive impairment (a-MCI). We recruited 22 23 a-MCI, we classified them subjects high (HEL) low educational level (LEL). All underwent neuropsychological assessment...
To investigate whether, in patients with amnesic mild cognitive impairment (a-MCI), recognition deficits are mainly due to a selective of recollection rather than familiarity.Nineteen a-MCI and 23 sex-, age-, education-matched healthy controls underwent two experimental investigations, using the Process Dissociation Procedure (PDP) Remember/Know (R/K) procedure, assess differential contribution familiarity their performance.Both procedures revealed preservation patients. Moreover, R/K...
Patients with Alzheimer's disease (AD) have heterogeneous rates of progression. The aim the current study is to investigate whether neuropsychiatric disturbances predict cognitive and functional progression in AD, according fail
The present study aimed to investigate prospective memory (PM) in persons with mild cognitive impairment (MCI).Twenty individuals MCI (10 an amnestic profile and 10 a dysexecutive of impairment) 20 control subjects (CS) were recruited. In the PM tasks, had execute three actions after min elapsed (time-based condition) or timer rang (event-based condition). Separate scores computed for correct recall intention perform (prospective component) execution (retrospective component).Although less...
Alzheimer's disease (AD) alters the functional connectivity of default mode network (DMN) but also topological properties connectome. Cognitive training (CT) is a tool to slow down AD progression and likely impact on connectivity. In this pilot study, we aimed at investigating brain changes after period CT active control (AC) in group 26 subjects with mild (mAD), amnestic cognitive impairment (aMCI), 29 healthy elderly (HE) people. They all underwent AC counterbalanced order following...
The hypothesis has been advanced that memory disorders in individuals with Parkinson's disease (PD) are related to either retrieval or consolidation failure. However, the characteristics of impairments PD patients amnestic mild cognitive impairment have not clarified. This study was aimed at investigating whether deficits (PDaMCI) due failure processes. Sixteen PDaMCI, 20 without (aMCINPD), and healthy controls were recruited. Participants administered Free Cued Selective Reminding Test. An...
Different aspects of episodic long-term, short-term and implicit long-term memory were investigated in subjects who strictly fulfilled the criteria for amnestic form Mild Cognitive Impairment (a-MCI). Results showed normal abilities these subjects, while each indices explored poorer results a-MCI with respect to controls. Although some functions relatively well preserved, others appeared have deteriorated a level comparable that mild AD patients. The finding an extensive impairment all...