A5024301232- Vestibular and auditory disorders
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Action Observation and Synchronization
- Advanced Neuroimaging Techniques and Applications
- Stress Responses and Cortisol
- Williams Syndrome Research
- Functional Brain Connectivity Studies
- Neuroendocrine regulation and behavior
- Cholinesterase and Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Motor Control and Adaptation
- Alzheimer's disease research and treatments
- Psychosomatic Disorders and Their Treatments
- Neuroscience of respiration and sleep
- Nerve injury and regeneration
- Transcranial Magnetic Stimulation Studies
- Olfactory and Sensory Function Studies
- Cannabis and Cannabinoid Research
- Nicotinic Acetylcholine Receptors Study
- Hemispheric Asymmetry in Neuroscience
- Ophthalmology and Eye Disorders
- Genetic Neurodegenerative Diseases
- Neural and Behavioral Psychology Studies
Fondazione Santa Lucia
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
Marconi University
2021
Sapienza University of Rome
2010-2019
Università Cattolica del Sacro Cuore
1979-1993
University of Perugia
1973
Alterations of the dopaminergic (DAergic) system are frequently reported in Alzheimer's disease (AD) patients and commonly linked to cognitive non-cognitive symptoms. However, cause DAergic dysfunction AD remains be elucidated. We investigated alterations midbrain Tg2576 mouse model AD, overexpressing a mutated human amyloid precursor protein (APPswe). Here, we found an age-dependent neuron loss ventral tegmental area (VTA) at pre-plaque stages, although substantia nigra pars compacta (SNpc)...
This study addresses the relationship between cochlear oxidative damage and auditory cortical injury in a rat model of repeated noise exposure. To test effect increased antioxidant defenses, water-soluble coenzyme Q 10 analog (Q ter ) was used. We analyzed function, stress, morphological alterations cortices structures, levels coenzymes 9 (CoQ CoQ , respectively) as indicators endogenous capability. report three main results. First, hearing loss hair cells spiral ganglion determined by...
Systemic inflammation might cause neuronal damage and sustain neurodegenerative diseases behavior impairment, with the participation of pro-inflammatory cytokines, like tumor necrosis factor (TNF)-α interleukin (IL)-18. However, potential contribution these cytokines to behavioral impairment in long-term period has not been fully investigated.Wistar rats were treated a single intraperitoneal injection LPS (5 mg/kg) or vehicle. After 7 days 10 months, animal was evaluated by testing specific...
As major components of neuronal membranes, omega-3 polyunsaturated acids (n-3 PUFA) exhibit a wide range regulatory functions, modulating from synaptic plasticity to neuroinflammation, oxidative stress neuroprotection. Recent human and animal studies indicated the n-3 PUFA neuroprotective properties in aging, with clear negative correlation between levels hippocampal deficits. The present multidimensional study was aimed at associating cognition, neurogenesis, volume, neurodegeneration...
What happens precociously to the brain destined develop Alzheimer's Disease (AD) still remains be elucidated and this is one reason why effective AD treatments are missing. Recent experimental clinical studies indicate that degeneration of dopaminergic (DA) neurons in Ventral Tegmental Area (VTA) could first events occurring AD. However, causes increased vulnerability DA Here, we deeply investigate physiology VTA before, at onset, after onset neurodegeneration. We use Tg2576 mouse model AD,...
Abstract Increasing evidence suggests cerebellar involvement in procedural learning. To further analyze its role and to assess whether it has a lateralized influence, the present study we used repetitive transcranial magnetic stimulation interference approach group of normal subjects performing serial reaction time task. We studied 36 volunteers: 13 underwent on left cerebellum performed task with right (6 subjects) or (7 hand; 10 hand ipsilateral (5 contralateral stimulation; another served...
Cognitive reserve (CR), for which formal education represents a proxy index, has been claimed as factor mitigating the clinical manifestations of Alzheimer disease (AD). The aim this study was to assess impact in modifying relationship between cerebral grey matter (GM) damage and large cohort patients with AD or amnesic mild cognitive impairment (a-MCI). We recruited 22 23 a-MCI, we classified them subjects high (HEL) low educational level (LEL). All underwent neuropsychological assessment...
Human and experimental studies have revealed putative neuroprotective pro-cognitive effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) in aging, evidencing positive correlations between peripheral n-3 PUFA levels regional grey matter (GM) volume, as well negative dietary cognitive deficits. We recently showed that supplemented aged mice exhibit better hippocampal-dependent mnesic functions, along with enhanced cellular plasticity reduced neurodegeneration, thus supporting a role...
Intraparenchymal injections of the immunotoxin 192-IgG-saporin into medial septum and nucleus basalis magnocellularis causes a selective depletion basal forebrain cholinergic neurons. Thus, it represents valid model to mimic key component cognitive deficits associated with aging dementia. Here we administered donepezil, potent acetylcholinesterase inhibitor developed for treating Alzheimer's disease, 15 days before injection, thus examined donepezil effects on neurodegeneration...
We tested the effects of 5-Hz repetitive transcranial magnetic stimulation (rTMS) over motor cortex in multiple sclerosis (MS) subjects with cerebellar symptoms. rTMS improved hand dexterity patients ( n = 8) but not healthy 7), as detected by a significant transient reduction time required to complete nine-hole pegboard task. may be useful approach treat impairment MS patients.