A5036638690- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- HER2/EGFR in Cancer Research
- Computational Drug Discovery Methods
- Estrogen and related hormone effects
- MRI in cancer diagnosis
- Cancer Genomics and Diagnostics
- Glutathione Transferases and Polymorphisms
- Advanced MRI Techniques and Applications
- Global Cancer Incidence and Screening
- Nutrition, Genetics, and Disease
- Gene expression and cancer classification
- Cancer Cells and Metastasis
- Monoclonal and Polyclonal Antibodies Research
- Metabolomics and Mass Spectrometry Studies
- Cancer Risks and Factors
- AI in cancer detection
- Bioinformatics and Genomic Networks
- Genomic variations and chromosomal abnormalities
- BRCA gene mutations in cancer
- Prostate Cancer Treatment and Research
- Cancer and Skin Lesions
- Angiogenesis and VEGF in Cancer
- Radiomics and Machine Learning in Medical Imaging
- Cell Adhesion Molecules Research
Norwegian University of Science and Technology
2015-2024
St Olav's University Hospital
2004-2008
Norwegian Cancer Society
1997
Molecular subtyping of breast cancer may provide additional prognostic information regarding patient outcome. However, its clinical significance remains to be established. In this study, the main aims were discover whether reclassification into molecular subtypes provides more precise outcome compared conventional histopathological grading and study cancer-specific survival in different subtypes. Cases occurring a cohort women born between 1886 1928 with long-term follow-up included study....
Abstract We examine the properties of several tests for goodness‐of‐fit multinomial logistic regression. One test is based on a strategy sorting observations according to complement estimated probability reference outcome category and then grouping subjects into g equal‐sized groups. A × c contingency table, where number values variable, constructed. The statistic, denoted as C , obtained by calculating Pearson χ 2 statistic expected frequencies are sum model‐based probabilities. Simulations...
The aims of this study were to characterize the metabolite profiles triple negative breast cancer (TNBC) and investigate associated with human epidermal growth factor receptor-2/neu (HER-2) overexpression using ex vivo high resolution magic angle spinning magnetic resonance spectroscopy (HR MAS MRS). Metabolic alterations caused by different estrogen receptor (ER), progesterone (PgR) HER-2 statuses also examined. To metabolic differences between two distinct groups, TNBC tumors compared...
Purpose This study aimed to evaluate whether MR metabolic profiling can be used for prediction of long‐term survival and monitoring treatment response in locally advanced breast cancer patients during neoadjuvant chemotherapy (NAC). Methods: High resolution magic angle spinning (HR MAS) spectra pre‐ post‐treatment biopsies from 33 were acquired. Tissue concentrations choline‐containing metabolites (tCho), glycine taurine assessed using electronic reference access vivo concentration (ERETIC)...
Today's clinical diagnostic tools are insufficient for giving accurate prognosis to breast cancer patients. The aim of our study was examine the tumor metabolic changes in patients with locally advanced caused by neoadjuvant chemotherapy (NAC), relating these treatment response and long-term survival. Patients (n = 89) participating a randomized open-label multicenter were allocated receive either NAC as epirubicin or paclitaxel monotherapy. Biopsies excised pre- post-treatment, analyzed...
// Elise Sandsmark 1 , Ailin Falkmo Hansen Kirsten M. Selnæs Helena Bertilsson 2, 3 Anna Bofin 4 Alan J. Wright 5 Trond Viset 6 Elin Richardsen 7, 8 Finn Drabløs Tone F. Bathen May-Britt Tessem 1, * Morten B. Rye 3, 9, Department of Circulation and Medical Imaging, Faculty Medicine, NTNU - Norwegian University Science Technology, Trondheim, Norway 2 Urology, St. Olavs Hospital, Trondheim Cancer Research Molecular Laboratory Children's Women's Health, UK Cambridge Institute, Cambridge, United...
CCND1 is located on 11q13. Increased copy number (CN) in breast cancer (BC) associated with high histopathological grade, proliferation, and Luminal B subtype. In this study of primary BCs corresponding axillary lymph node metastases (LNM),we examine associations between CN proliferation status, molecular subtype, prognosis. Furthermore, we studied CNs FGFR1 ZNF703, both which are 8p12. Fluorescence situ hybridization probes for chromosome 11 centromere were used tissue microarrays...
Stromal tissue in the breast plays a key role cancer invasiveness due to molecular and cellular changes. Collagen is main component of stroma. The purposes this study were investigate differences collagen fibre patterns between tumour‐induced stromal normal stroma, high‐grade low‐grade using second harmonic generation microscopy. Thirty‐seven ductal carcinomas examined: Twenty‐one Luminal A phenotype sixteen HER 2 or Basal‐like phenotype. Three regions examined each case: intratumoral,...
The phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in cancer cells through numerous mutations and epigenetic changes. recent development of inhibitors targeting different components the PI3K may represent a valuable treatment alternative. However, predicting efficacy these drugs challenging, methods for therapy monitoring are needed. Basal-like breast (BLBC) an aggressive subtype, associated with activation. objectives this study were to quantify activity tissue...
The aim of this study was to compare breast cancer specific survival (BCSS) for invasive lobular carcinoma (ILC) and ductal (IDC) and, further, evaluate critically the prognostic value histopathological grading ILC examine E-cadherin as a marker in ILC.The comprised 116 611 carcinomas occurring between 1961 2008. All cases had been classified previously according type grade, stained oestrogen receptor (ER), progesterone (PR), antigen Ki67 (Ki67), epithelial growth factor (EGFR), cytokeratin...
We compared fluorescence in situ hybridization (FISH), immunohistochemical analysis, immunocytochemical and relative quantification assays using polymerase chain reaction (PCR) as methods for estimating HER-2 gene amplification protein overexpression infine-needle aspirate (FNA) specimens paraffin-embedded tissue samples from 49 cases of breast cancer: FISH can be performed successfully on FNA smears. Immunohistochemical staining intensity 3+ corresponds to a ratio more than 2.5. 2+ 1+ are...
TMPRSS2-ERG has been proposed to be a prognostic marker for prostate cancer. The aim of this study was identify changes in metabolism, genes and biochemical recurrence related by using an integrated approach, combining metabolomics, transcriptomics, histopathology clinical data cohort 129 human samples (41 patients). Metabolic analyses revealed lower concentrations citrate spermine comparing ERGhigh ERGlow samples, suggesting increased cancer aggressiveness compared ERGlow. These results...
Abstract The long non-coding RNA NEAT1 locus is transcribed into two overlapping isoforms, NEAT1_1 and NEAT1_2 , of which the latter essential for assembly nuclear paraspeckles. abnormally expressed in a wide variety human cancers. Emerging evidence suggests that isoforms have distinct functions gene expression regulation, recently it was shown but not predicts poor clinical outcome cancer. Here, we report correlates with HER2-positive breast cancers high-grade disease. We provide pattern...
We compared fluorescence in situ hybridization (FISH), immunohistochemical analysis, immunocytochemical and relative quantification assays using polymerase chain reaction (PCR) as methods for estimating HER-2 gene amplification protein overexpression fine-needle aspirate (FNA) specimens paraffin-embedded tissue samples from 49 cases of breast cancer. FISH can be performed successfully on FNA smears. Immunohistochemical staining intensity 3+ corresponds to a ratio more than 2.5. 2+ 1+ are not...
The purpose of this study was to evaluate the use dynamic contrast-enhanced (DCE) MRI, in vivo (1)H MRS and ex high resolution magic angle spinning (HR MAS) tissue samples as methods detect early treatment effects docetaxel a breast cancer xenograft model (MCF-7) mice. MCF-7 cells were implanted subcutaneously athymic mice treated with (20, 30, 40 mg/kg) or saline six weeks later. DCE-MRI performed on 7 T MR system three days after treatment. images used input for two-compartment model,...
Abstract Background The aim of this retrospective matched cohort study was to evaluate the rate recurrence among women with delayed large flap breast reconstruction after mastectomy for cancer. treated at a single hospital compared that in an individually control group cancer who did not have mastectomy. Methods Between 1982 and 2001, 125 previous invasive carcinoma underwent pedicled musculocutaneous or microvascular flaps (a median 32 months mastectomy). They were 182 had but undergo...
Purpose To investigate the effect of bevacizumab treatment on vascular architecture and function in two xenograft models with different angiogenic properties using diffusion‐weighted magnetic resonance imaging (DW‐MRI) dynamic contrast‐enhanced MRI (DCE‐MRI). Materials Methods Mice carrying basal‐like (MAS98.12) or luminal‐like (MAS98.06) orthotopic breast cancer xenografts were treated (5 mg/kg), doxorubicin (8 both drugs combination. DW‐MRI DCE‐MRI performed before 3 days after a Bruker 7T...
Abstract Background: Secular trends in incidence and prognosis of molecular breast cancer subtypes are poorly described. We studied long-term a population Norwegian women born 1886–1977. Methods: A total 52,949 were followed for incidence, 1,423 tumors reclassified into using IHC situ hybridization. compared rates among 1886–1928 1929–1977, estimated age-specific rate ratios (IRR), performed multiple imputations to account unknown subtype. Prognosis was diagnosed before 1995 or later,...
The phosphoinositide-3 kinase (PI3K) pathway is an attractive therapeutic target. However, difficulty in predicting response limits the clinical implementation of PI3K inhibitors. This study evaluates utility clinically relevant magnetic resonance imaging (MRI) biomarkers for noninvasively assessing vivo to dual PI3K/mTOR inhibitor BEZ235 two ovarian cancer models with differential activity. signalling activity TOV-21G and TOV-112D human cells was investigated vitro. Cellular vascular...
Deep convolutional neural networks (CNNs) are the current state-of-the-art for digital analysis of histopathological images. The large size whole-slide microscopy images (WSIs) requires advanced memory handling to read, display and process these There several open-source platforms working with WSIs, but few support deployment CNN models. These applications use third-party solutions inference, making them less user-friendly unsuitable high-performance image analysis. To make CNNs feasible on...
Abstract Purpose: To explore tumor pathophysiology with special attention to the microenvironment in two molecular subtypes of human breast cancer using vivo magnetic resonance imaging (MRI) and histopathology. The impact growth, size, influence estradiol were also investigated. Materials Methods: Two orthotopic directly transplanted models representing luminal‐like basal‐like characterized by dynamic contrast‐enhanced MRI diffusion‐weighted MRI. Ex measurements vascularization, hypoxia,...
The aims of this study were to examine microvessel density (MVD), proliferating MVD (pMVD) and Vascular Proliferation Index (VPI) in basal-like phenotype (BP) luminal A subtypes breast cancer their prognostic value.Dual-colour immunohistochemistry for von Willebrand factor Ki67 was done on sections from 62 BP tumours matched grade selected 909 cancers previously reclassified into molecular subtypes. Associations between MVD, pMVD VPI, prognosis estimated using linear regression survival...