A5082523626- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Chronic Myeloid Leukemia Treatments
- Eosinophilic Disorders and Syndromes
- Immunodeficiency and Autoimmune Disorders
- Multiple Myeloma Research and Treatments
- Retinoids in leukemia and cellular processes
- Acute Lymphoblastic Leukemia research
- Immune Cell Function and Interaction
- Kruppel-like factors research
- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Hematological disorders and diagnostics
- CNS Lymphoma Diagnosis and Treatment
- Histiocytic Disorders and Treatments
- Epigenetics and DNA Methylation
- Salivary Gland Disorders and Functions
- Cancer-related gene regulation
- Erythrocyte Function and Pathophysiology
- Blood disorders and treatments
- Protein Degradation and Inhibitors
- Hemoglobinopathies and Related Disorders
Northwestern University
2016-2025
Northwestern Memorial Hospital
2015-2025
Columbia University Irving Medical Center
2020
Johns Hopkins Hospital
2020
University of North Carolina at Chapel Hill
2020
Duke University
2020
Calgary Laboratory Services
2019
University of Calgary
2019
European Institute of Oncology
2019
Washington University in St. Louis
2019
Abstract Sjögren's syndrome‐like autoimmune exocrinopathy (AEC) in the nonobese diabetic (NOD) mouse progresses from a preimmune phase to an immune phase, resulting dry mouth and/or eyes. In present study, impact of prototypical T‐helper type 1 cytokine, interferon‐gamma (IFN‐γ), on onset AEC was investigated using both IFN‐γ and receptor gene knockout mice, NOD. –/– IFN‐γR , respectively. Neither nor mice exhibited increased acinar cell apoptosis abnormal salivary protein expression,...
Mantle cell lymphoma (MCL) expresses pan-B-cell antigens and is usually CD5+/CD10-/CD23-/FMC7+. In this study, we evaluated 52 patients with confirmed diagnoses of MCL identified variant immunophenotypes in 21 (19/48 classical 2/4 MCLs), including CD5- 6 (12%) 52, CD10+ 4 (8%) 50, CD23+ 10 (21%) 48, FMC7- (11%) 37 cases. Three cases showed variations 2 antigens, CD5-/CD23+, CD10+/FMC7-, CD23+/FMC7-; they were all MCLs. One blastoid was CD23+, one FMC7-. Evaluation for proliferation index by...
Myelofibrosis is characterized by bone marrow fibrosis, atypical megakaryocytes, splenomegaly, constitutional symptoms, thrombotic and hemorrhagic complications, a risk of evolution to acute leukemia. The JAK kinase inhibitor ruxolitinib provides therapeutic benefit, but the effects are limited. purpose this study was determine whether targeting AURKA, which has been shown increase maturation potential benefit for patients with myelofibrosis.Twenty-four myelofibrosis were enrolled in phase I...
Abstract Ibrutinib inhibits Bruton tyrosine kinase while venetoclax is a specific inhibitor of the anti-apoptotic protein BCL2. Both drugs are highly effective as monotherapy against chronic lymphocytic leukemia (CLL), and clinical trials using combination therapy have produced remarkable results in terms rate complete remission frequency undetectable minimal residual disease. However, laboratory rationale behind success drug still lacking. A better understanding how these two synergize...
ABSTRACT Objectives The clinicopathologic and prognostic features of somatic NF1 mutations have been well studied in pediatric myeloid neoplasms adult acute leukemia (AML) but not chronic (CMNs), including myelodysplastic syndrome (MDS), myeloproliferative (MPNs), myelodysplastic/myeloproliferative (MDS/MPNs). Methods A retrospective review was performed to identify patients diagnosed with ‐mutated CMNs between 1/2010 8/2023. Patients wildtype ( ‐WT) concurrently during the same time were...
Background: Based on CD14/CD16 expression, monocytes can be divided into the following three functionally distinct subsets: classical (MO1, CD14++/CD16-), intermediate (MO2, CD14+/CD16+) and non-classical (MO3, CD14dim/CD16-). An expanded MO1 subset (cutoff, ≥94%) was found to predictive of CMML. However, utility this test in routine practice has important limitations, with some reporting low sensitivity or a lack correlation. Here, we sought evaluate practical usefulness by using our...
Abstract Objective Sjögren's syndrome (SS) is an autoimmune disease affecting primarily the salivary and lacrimal glands, leading to dry mouth eyes. Recent studies have suggested that autoantibodies reactive with type 3 muscarinic acetylcholine receptors (M3Rs) expressed on gland cells may be highly specific for SS. To test this hypothesis, we constructed a cell line expressing human M3R gene in order screen anti‐M3R sera from SS patients. Methods Complementary DNA encoding open‐reading...
Information on bronchoalveolar lavage (BAL) in patients with COVID-19 is limited, and clinical correlation has not been reported. This study investigated the key features of BAL fluids from assessed their significance. A total 320 samples 83 70 non-COVID-19 (27 other respiratory viral infections) were evaluated, including cell count/differential, morphology, flow cytometric immunophenotyping, immunohistochemistry. The findings correlated outcomes. Compared to patients, was characterized by...
V617F driver mutation of JAK2 is the leading cause Philadelphia-chromosome-negative myeloproliferative neoplasms (MPNs). Although thrombosis a mortality and morbidity in MPNs, mechanisms underlying their pathogenesis are unclear. Here, we identified pleckstrin-2 (Plek2) as downstream target JAK2/STAT5 pathway erythroid myeloid cells, showed that it upregulated JAK2V617F-positive MPN mouse model patients with MPNs. Loss Plek2 ameliorated JAK2V617F-induced phenotypes including erythrocytosis,...