A5092575798- Sarcoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Breast Lesions and Carcinomas
- Lymphoma Diagnosis and Treatment
- Neuroscience of respiration and sleep
- HER2/EGFR in Cancer Research
- Ovarian cancer diagnosis and treatment
- Ear and Head Tumors
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Uterine Myomas and Treatments
- Respiratory Support and Mechanisms
- Peptidase Inhibition and Analysis
- Cardiac tumors and thrombi
- Cardiac Arrest and Resuscitation
- Cancer and Skin Lesions
Northwestern University
2022-2024
Northwestern Memorial Hospital
2024
Lurie Children's Hospital
2024
Central Michigan University
2018
Abstract Background MEIS1::NCOA2 is a rare fusion gene that has been recently described in subset of spindle cell rhabdomyosarcomas and multiple low-grade undifferentiated sarcomas predominantly arising the genitourinary gynecologic tracts with no specific line differentiation. We present first documented case this neoplasm as lung primary tumor. Case Presentation A 74-year-old woman 40-year smoking history presented 2.1 × 1.7 cm nodule discovered on computed tomography (CT) scan. biopsy...
Therapy-related myeloid neoplasms (t-MNs) are a complication of treatment with cytotoxic chemotherapy and/or radiation therapy. The majority t-MNs show chromosomal abnormalities associated myelodysplastic syndrome (MDS) or KMT2A rearrangements and characterized by poor clinical outcomes. A small but substantial subset patients have normal karyotype (NK) their characteristics mutational profiles not well studied. We retrospectively studied diagnosed t-MN at three institutions compared the...
Leiomyoma with bizarre nuclei (LM-BN) is a rare variant of leiomyoma benign clinical course. In contrast, leiomyosarcoma (LMS) high-grade, malignant neoplasm characterized by high recurrence rates and poor survival. While LM-BN LMS show distinct morphologies, they share similar immunoprofiles molecular alterations, both considered 'genomically unstable'. Rare cases associated have been reported; however, the histogenesis relationship between these two tumors remains unclear. this study, we...
Introduction Histiocytoid lobular breast carcinoma is a rare subtype of invasive characterized by relatively bland, uniform nuclei, single small eosinophilic nucleolus, and ample granular cytoplasm. These cancers are typically triple negative, show frequent androgen receptor (AR) positivity, therefore theorized to represent variant apocrine differentiation in carcinoma. Anecdotal evidence suggests that these tumors have excellent outcomes, though some studies suggest variable clinical...
Abstract Background: Human epidermal growth factor receptor 2 (HER2) is a transmembrane tyrosine kinase that encoded by the ERBB2 gene, located on chromosome 17. Expression levels of HER2 are key pathogenic and treatment-associated in breast carcinomas, with expression reported as per ASCO/CAP scoring guidelines. Outside intense focus overexpression few studies currently exist look at comprehensive molecular profile these aggressive tumors. Design: Our institutional pathology database was...
Respiratory autoresuscitation is normally a robust process that restores eupneic breathing rhythm following severe hypoxemia‐induced respiratory arrest. We previously found urethane anesthesia prevents autoresustitation and causes predictable cardiorespiratory collapse sudden death as result of even single episode hypoxemia [Krause et al (2016); Respir Physiol Neurobiol. 232:43–53]. It unknown whether this failure to autoresuscitate due or cardiovascular deficit. hypothesized in condition...