A5023484082- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Estrogen and related hormone effects
- Advanced Breast Cancer Therapies
- Cancer and Skin Lesions
- Cancer Immunotherapy and Biomarkers
- Cancer Treatment and Pharmacology
- Monoclonal and Polyclonal Antibodies Research
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- Salivary Gland Tumors Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Nuclear Structure and Function
- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Breast Implant and Reconstruction
- Developmental Biology and Gene Regulation
Northwestern University
2015-2025
Northwestern Memorial Hospital
2011-2024
Rush University
2008-2023
Breast Cancer Research Foundation
2023
Midwestern University
2023
Roche (Switzerland)
2022
NRG Oncology
2020-2021
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
2015-2020
Indo-American Center
2015
Dartmouth–Hitchcock Medical Center
2014
Abstract High expression of Notch-1 and Jagged-1 mRNA correlates with poor prognosis in breast cancer. Elucidating the cross-talk between Notch other major cancer pathways is necessary to determine which patients may benefit from inhibitors, agents should be combined them, biomarkers indicate activity vivo. We explored receptors ligands clinical specimens, as well activity, regulation, effectors signaling using cell lines xenografts. Ductal lobular carcinomas commonly expressed Notch-1,...
Tumor metastasis remains the major cause of cancer-related death, but its molecular basis is still not well understood. Here we uncovered a splicing-mediated pathway that essential for breast cancer metastasis. We show RNA-binding protein heterogeneous nuclear ribonucleoprotein M (hnRNPM) promotes by activating switch alternative splicing occurs during epithelial–mesenchymal transition (EMT). Genome-wide deep sequencing analysis suggests hnRNPM potentiates TGFβ signaling and identifies CD44...
Obesity has been shown to increase breast cancer risk. FTO is a novel gene which identified through genome wide association studies (GWAS) be related obesity. Our objective was evaluate tissue expression of in and the role SNPs predicting We performed case-control study 354 cases 364 controls. This conducted at Northwestern University. examined single nucleotide polymorphisms (SNPs) intron 1 genotyped controls for four SNPs: rs7206790, rs8047395, rs9939609 rs1477196. also evaluated normal...
Abstract Solid papillary carcinoma with reverse polarity (SPCRP) is a rare breast cancer subtype an obscure etiology. In this study, we sought to describe its unique histopathologic features and identify the genetic alterations that underpin SPCRP using massively parallel whole-exome targeted sequencing. The morphologic immunohistochemical of support invasive nature subtype. Ten 13 (77%) SPCRPs harbored hotspot mutations at R172 isocitrate dehydrogenase IDH2, which 8 10 displayed concurrent...
We describe the genomic landscape of circulating tumour DNA (ctDNA) across pathological subtypes metastatic breast cancer.
Triple-negative breast cancer (TNBC) accounts for approximately 12% to 17% of all cancers and has an aggressive clinical behavior. Increased tumor-infiltrating lymphocyte counts are prognostic survival in TNBC, making this disease a potential target immunotherapy. Research on immunophenotyping lymphocytes is revealing molecular structural organization the tumor microenvironment that may predict patient prognosis. The anti-programmed death-ligand 1 (PD-L1) antibody atezolizumab plus...
Abstract: The purpose of this study was to determine if any relationship exists between Her-2/neu gene amplification and estrogen receptor (ER), progesterone (PR), MIB-1, grade, size age in female breast cancer. Five hundred eighteen patients with invasive carcinoma, 390 ductal 128 lobular, which assessment by fluorescence in-situ hybridization (FISH) has been performed, were reviewed retrospectively. Each patient further assessed for ER, PR, at diagnosis. Chi-square analysis then used...
Abstract Purpose: Circulating tumor DNA (ctDNA) is a promising tool for noninvasive longitudinal monitoring of genomic alterations. We analyzed serial ctDNA to characterize evolution in progressive metastatic breast cancer. Experimental Design: This was retrospective cohort between 2015 and 2019 obtained under an Institutional Review Board–approved protocol at Northwestern University (Chicago, IL). samples were with Guardant360 next-generation sequencing (NGS) assay. A total 86 patients had...
Mucocele-like lesion (MLL) is a rare mucinous of the breast with highly variable upgrade rates to atypia or malignancy on excision. This spectrum data has led differing opinions need for surgical We evaluated 50 core biopsy specimens diagnosed as having MLLs and correlated findings those excision pathology. Thirty-eight patients underwent 29 were benign (76%), 4 had atypical ductal hyperplasia (11%), 5 carcinoma in situ (13%), an overall rate 13%. However, risk was exclusively associated...
PURPOSE Preclinical studies report that trastuzumab (T) can boost radiotherapy (RT) effectiveness. The primary aim of the B-43 trial was to assess efficacy RT alone vs concurrent plus T in preventing recurrence ipsilateral breast cancer (IBTR) women with ductal carcinoma situ (DCIS). PATIENTS AND METHODS Eligibility: Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1, DCIS resected by lumpectomy, known estrogen receptor (ER) and/or progesterone (PgR), and human epidermal...