A5065531168- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Cytokine Signaling Pathways and Interactions
- Chronic Lymphocytic Leukemia Research
- Mathematical Biology Tumor Growth
- Lymphoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Monoclonal and Polyclonal Antibodies Research
- Genetic Neurodegenerative Diseases
- Breast Cancer Treatment Studies
- Mitochondrial Function and Pathology
- Genetic factors in colorectal cancer
- Nuclear Structure and Function
- Breast Lesions and Carcinomas
- RNA Research and Splicing
- Chronic Myeloid Leukemia Treatments
- Advanced Biosensing Techniques and Applications
- Cancer and Skin Lesions
- Estrogen and related hormone effects
- Lipid Membrane Structure and Behavior
- Cancer, Stress, Anesthesia, and Immune Response
- Microtubule and mitosis dynamics
- Gene expression and cancer classification
- Force Microscopy Techniques and Applications
Tempus Labs (United States)
2023-2025
AstraZeneca (United States)
2019-2024
Memorial Sloan Kettering Cancer Center
2015-2023
Amgen (United States)
2023
University of California, Irvine
2022
Brown University
2015-2021
National University of Singapore
2021
National Bureau of Economic Research
2021
University of Illinois Urbana-Champaign
2021
Congressional Budget Office
2021
Article8 August 2017Open Access Transparent process Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity Zachary Monahan Department Pharmacology Molecular Therapeutics, Uniformed Services University, Bethesda, MD, USA Search for more papers by this author Veronica H Ryan Neuroscience Graduate Program, Brown Providence, RI, Abigail M Janke Pharmacology, Physiology, Biotechnology, Kathleen A Burke Shannon N Rhoads Gül Zerze Chemical Biomolecular...
Abstract Clear cell carcinoma of the endometrium is a rare type endometrial cancer that generally associated with an aggressive clinical behaviour. Here, we sought to define repertoire somatic genetic alterations in clear carcinomas (ECCs), and whether ECCs could be classified into molecular subtypes described for endometrioid serous carcinomas. We performed rigorous histopathological review, immunohistochemical analysis massively parallel sequencing targeting 300 cancer‐related genes 32...
An immunoelectroosmophoretic technique for rapid detection of the antigen (SH) associated with serum hepatitis virus has been devised. The maintains specificity characteristic Ouchterlony gel-diffusion method, yet detects in 1 to 2 hours one-tenth amount required gel diffusion. test immediate application blood-banking practice since it permits screening such labile products as platelets and fresh whole blood, additional serums negative by technique.
Purpose: Metaplastic breast carcinoma (MBC) is a rare and aggressive histologic type of cancer, predominantly triple-negative phenotype, characterized by the presence malignant cells showing squamous and/or mesenchymal differentiation. We sought to define repertoire somatic genetic alterations mutational signatures MBCs.Experimental Design: Whole-exome sequencing was performed in 35 MBCs, with 16, 10, 9 classified as harboring chondroid, spindle, metaplasia predominant metaplastic component....
Adenomyoepithelioma of the breast is a rare tumor characterized by epithelial-myoepithelial differentiation, whose genetic underpinning largely unknown. Here we show through whole-exome and targeted massively parallel sequencing analysis that whilst estrogen receptor (ER)-positive adenomyoepitheliomas display PIK3CA or AKT1 activating mutations, ER-negative harbor highly recurrent codon Q61 HRAS hotspot which co-occur with PIK3R1 mutations. In two- three-dimensional cell culture models,...
There are a vast number of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's (PD), and Huntington's (HD), associated with the rearrangement specific proteins to non-native conformations that promotes aggregation deposition within tissues and/or cellular compartments. These diseases commonly classified as protein-misfolding or amyloid diseases. The interaction these liquid/surface interfaces is fundamental phenomenon potential implications for Kinetic thermodynamic...
Abstract Solid papillary carcinoma with reverse polarity (SPCRP) is a rare breast cancer subtype an obscure etiology. In this study, we sought to describe its unique histopathologic features and identify the genetic alterations that underpin SPCRP using massively parallel whole-exome targeted sequencing. The morphologic immunohistochemical of support invasive nature subtype. Ten 13 (77%) SPCRPs harbored hotspot mutations at R172 isocitrate dehydrogenase IDH2, which 8 10 displayed concurrent...
Phyllodes tumours (PTs) are breast fibroepithelial lesions that graded based on histological criteria as benign, borderline or malignant. PTs may recur locally. Borderline and malignant metastasize to distant sites. Breast lesions, including fibroadenomas, characterized by recurrent MED12 exon 2 somatic mutations. We sought define the repertoire of genetic alterations in whether these assist differential diagnosis lesions. collected 100 40 benign PTs, 14 22 PTs; six, six 13 respectively,...
Abstract Uterine adenosarcomas ( UAs ) are biphasic lesions composed of a malignant mesenchymal (ie stromal) component and an epithelial component. generally low‐grade have favourable prognosis, but may display sarcomatous overgrowth SO ), which is associated with worse outcome. We hypothesized that, akin to breast fibroepithelial lesions, neoplasms in clonal somatic genetic alterations restricted the To characterize test this hypothesis, we subjected 20 combination whole‐exome n = 6),...
Resistance to anti-HER2 therapies in HER2
Huntington disease (HD) is caused by an expanded polyglutamine (poly(Q)) repeat near the N terminus of huntingtin (htt) protein. Expanded poly(Q) facilitates formation htt aggregates, eventually leading to deposition cytoplasmic and intranuclear inclusion bodies containing htt. Flanking sequences directly adjacent domain, such as first 17 amino acids on (Nt17) polyproline (poly(P)) domain C-terminal side heavily influence aggregation. Additionally, interacts with a variety membraneous...
Alteration of the extracellular matrix in tumor stroma influences efficiency cell locomotion away from primary into surrounding tissues and vasculature, thereby affecting metastatic potential. We study changes breast cancer through use second harmonic generation (SHG) collagen order to improve current understanding stromal development. Specifically, we utilize a quantitative analysis ratio forward backward propagating SHG signal (F/B ratio) monitor throughout ductal lobular carcinoma After...
Abstract Emotional stress activates the sympathetic nervous system (SNS) and release of neurotransmitter norepinephrine to promote breast tumor pathogenesis. We demonstrate here that metastatic mammary adenocarcinoma cell line 4T1 does not express functional adrenergic receptors (AR), activated by norepinephrine, yet stimulation receptor in vivo altered progression vivo. Chronic treatment with antidepressant desipramine (DMI) inhibit reuptake increased growth but metastasis. Treatment a...
Metaplastic breast cancer (MBC) is a rare special histologic type of triple-negative cancer, characterized by the presence neoplastic cells showing differentiation towards squamous epithelium and/or mesenchymal elements. Here we sought to define whether histologically distinct subgroups MBCs would be underpinned genomic transcriptomic alterations. Microarray-based copy number profiling identified limited but significant differences between MBC subtypes studied here, despite sample size (n =...