Lei Liu

ORCID: 0000-0001-9225-6182
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About
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Research Areas
  • Hair Growth and Disorders
  • Urinary Bladder and Prostate Research
  • Reproductive Physiology in Livestock
  • Hormonal and reproductive studies
  • Reproductive Biology and Fertility
  • Reproductive System and Pregnancy
  • Sirtuins and Resveratrol in Medicine
  • Pregnancy and preeclampsia studies
  • Adipose Tissue and Metabolism
  • Wound Healing and Treatments
  • Dermatologic Treatments and Research
  • dental development and anomalies
  • Gestational Diabetes Research and Management
  • Nuts composition and effects
  • HIV, Drug Use, Sexual Risk
  • Growth Hormone and Insulin-like Growth Factors
  • Effects of Environmental Stressors on Livestock
  • Sport Psychology and Performance
  • Migraine and Headache Studies
  • Sexual Differentiation and Disorders
  • Bone and Joint Diseases
  • HIV-related health complications and treatments
  • Wnt/β-catenin signaling in development and cancer
  • Ion channel regulation and function
  • Pharmacological Effects and Toxicity Studies

Shihezi University
2025

Second Hospital of Shandong University
2023

Shandong Agricultural University
2021-2022

First Affiliated Hospital of GuangXi Medical University
2022

Guangxi Medical University
2022

Obstetrics and Gynecology Hospital of Fudan University
2022

Hunan Agricultural University
2018

Harbin Medical University
2017

Daqing City People's Hospital
2017

Jinzhou Medical University
2016

We investigated the role of large-conductance Ca 2+ -activated K + (BK) channels in β3-adrenoceptor (β3-AR)-induced relaxation rat urinary bladder smooth muscle (UBSM). BRL 37344, a specific β3-AR agonist, inhibits spontaneous contractions isolated UBSM strips. SR59230A, antagonist, and H89, PKA inhibitor, reduced inhibitory effect 37344. Iberiotoxin, BK channel shifts 37344 concentration response curves for contraction amplitude, net force, tone to right. Freshly dispersed cells perforated...

10.1152/ajpcell.00001.2008 article EN AJP Cell Physiology 2008-09-18

Pre-eclampsia is a severe hypertensive disorder of pregnancy (HDP), mainly characterized by new-onset hypertension with proteinuria after 20-week gestation. Sirtuin1 (SIRT1), class III histone deacetylase, associated the regulation various pathophysiological processes, including inflammation, immune response, metabolism, and autophagy. However, effect SIRT1 in pathogenesis pre-eclampsia remains to be elucidated. In this study, we found that expression was relatively lower placentas serum...

10.3390/biom12030422 article EN cc-by Biomolecules 2022-03-09

In urinary bladder smooth muscle (UBSM), stimulation of beta-adrenergic receptors (beta-ARs) leads to activation the large-conductance Ca2+-activated K+ (BK) channel currents (Petkov GV and Nelson MT. Am J Physiol Cell 288: C1255-C1263, 2005). this study we tested hypothesis that BK mediates UBSM relaxation in response beta-AR using highly specific inhibitor iberiotoxin (IBTX) a knockout (BK-KO) mouse model which gene for pore-forming subunit was deleted. strips isolated from wild-type (WT)...

10.1152/ajprenal.00440.2007 article EN AJP Renal Physiology 2008-10-01

Rapid uterus involution is essential for minimising interpartum intervals, enhancing reproductive performance, and optimising production in ewes. This study aimed to accelerate the uterine of postpartum ewes through a relatively simple hormone treatment approach. In this study, 96 Dorper × Hu F1 were assigned three groups. The subsequently injected with normal saline (control group), prostaglandin + oxytocin (PG OT group) horse chorionic gonadotropin eCG group). Each group had 16 producing...

10.1111/rda.70044 article EN Reproduction in Domestic Animals 2025-03-01

<b>Background:</b> Hair loss is seen as an irreversible process. Most research concentrates on how to elongate the anagen, reduce negative factors of obstructing hair growth and improve number size. <b>Aim:</b> In our experiment, we tried prove that cow placenta extract can promote by elongating shaft increasing follicle number. <b>Materials Methods:</b> Cow (CPE), water minoxidil applied separately back depilated B57CL/6 mice for case, positive control respectively. We checked proliferation...

10.4103/0019-5154.77544 article EN cc-by-nc-sa Indian Journal of Dermatology 2011-01-01

VOLUME 287 (2012) PAGES 32307–32311 In Figs. 2D, 3A, and 3E, the samples were run on gels with 18 wells, which contain repetition of some lanes also combination different experiments. The interest parts same gel. To make it easy for readers to interpret, spliced together. However, splicing was not made clear by insertion dividing lines. Corrected versions figures are shown below lines between lanes. addition, in 2D labels “NRS” “SIRT2” top supposed show NRS or antibody that used coat beads...

10.1074/jbc.a112.403048 article EN cc-by Journal of Biological Chemistry 2013-05-01

The purpose of this study was to investigate the effects on growth Lysine (Lys) supplementation in a low protein diet. We also investigated gene or expression related skeletal muscle development and intestinal amino acid transporters, determined major signalling associated with Lys-regulating development. 1000 healthy, weights averaging 938.6 ± 6.54 g weaned rabbits were randomly divided into five groups (five replicates each group 40 replicate). These consisted normal (NP group, consuming...

10.1111/jpn.13632 article EN Journal of Animal Physiology and Animal Nutrition 2021-09-08

Rex rabbits are important fur rabbits. Heat stress severely reduces the quality of The aim this study was to experimentally investigate effect dietary vitamin A (VA) addition on hair follicle development and related signal pathways in under heat stress.In experiment, 90 were randomly divided into three groups: control group (20-25 °C, fed basic diet), (30-34 + VA 12 000 IU/kg diet). could significantly increase density (P < 0.01), length 0.05), ratio secondary primary follicles 0.05). In...

10.1002/jsfa.11567 article EN Journal of the Science of Food and Agriculture 2021-10-09

In the present experiment, we study function of methionine on hair follicle development in heat-stressed Rex Rabbits and its potential molecular mechanism. rabbits were randomly divided into 5 groups (30 replicates per group): control group (20–25°C, fed basic diet), heat stress (30–34°C, + 0.15% addition to diet). diet (control), 0.3% 0.45% The results show that decreases density rabbits, significantly increases (p < .05). Heat increased serum HSP70 concentration skin gene expression,...

10.1096/fj.202200520 article EN The FASEB Journal 2022-07-26

The pattern of murine hair growth has been seen as an unpredictable and irregular process. In this study, nude mice were used to investigate the find impact exogenous stimulations on changing pattern. We found mouse appeared in waves from head posterior part back for first time. Amongst all six groups, male had a more regular cycle than females: back. When there was no mouse, we named time 'no-hair phase' opposite 'hair-existing phase'. Exogenous significantly elongated hair-existing...

10.3109/09546634.2010.495378 article EN Journal of Dermatological Treatment 2010-10-22

The present study aimed to investigate the effect of traditional Chinese kidney reinforcing and marrow-beneficial medicine (KRMB) on prevention treatment abnormal bone metabolism osteoporosis (OP) resulting from spinal cord injury (SCI). Rat models OP following SCI were surgically established. rats randomly divided into five groups: Normal; sham operation + KRMB; normal model group. Bone mineral density (BMD), expression gamma‑carboxyglutamic‑acid containing protein (BGP), hepcidin mRNA...

10.3892/etm.2016.3304 article EN Experimental and Therapeutic Medicine 2016-04-27

5-Hydroxytryptamine (5-HT) can enhance human ureteral contractions. However, the mediating receptors have not been clarified. This study sought to further characterize using several selective antagonists and agonists. Human distal ureters were obtained from 96 patients undergoing cystectomy. The mRNA expression levels of 5-HT examined RT-qPCR experiments. phasic contractions ureter strips, either spontaneous or evoked with neurokinin, recorded in an organ bath. Among 13 receptors, 5-HT2A...

10.1016/j.ejphar.2023.175715 article EN cc-by-nc-nd European Journal of Pharmacology 2023-04-12

Introduction Sirt3, a major deacetylase in mitochondria, plays pivotal role the regulation of lipid metabolism mice and humans. Dynamic changes Sirt3 expression are observed ruminants during transition period, time when fat mobilization initiates non‐esterified fatty acids (NEFA) sore plasma, also most disorders take place, like liver ketosis etc. However, rationale between disturbance dairy cows has not been characterized yet. The current study aims to investigate interrelations NEFA on...

10.1096/fasebj.2018.32.1_supplement.879.7 article EN The FASEB Journal 2018-04-01

The aim of this study was to develop a novel Eustachian tube (ET) test consisting sonotubometry with nasopharynx under pressure measure opening the ET. We assessed advantages approach compared those only or tubomanometry and explored possibility quantifying ET patency.This prospective clinical at tertiary referral center.Sonotubometry, tubomanometry, were performed on total 106 ears. ET-opening detection rates different methods McNemar's Fisher's exact test. correlation between latency index...

10.1097/mao.0000000000003511 article EN Otology & Neurotology 2022-03-02

The cover image is based on the Original Article Tetrahedral framework nucleic acids promote diabetic wound healing via Wnt signalling pathway by Zejing Wang et al., https://doi.org/10.1111/cpr.13316.

10.1111/cpr.13357 article EN cc-by Cell Proliferation 2022-11-01
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