Short-chain fatty acids (SCFAs) (a microbial fermentation production in the rabbit gut) have an important role many physiological processes, which may be related to reduced body fat of rabbits. In present experiment, we study function acetate major SCFA on metabolism. Ninety rabbits (40 days age) were randomly divided into three groups: a sham control group (injection saline for four days); experiencing subcutaneous injection (2 g/kg BM per day, one each acetate); and pair-fed treatment...

The present study aimed to explore the protective effects of exogenous catalase (CAT) from microorganisms against lipopolysaccharide (LPS)-induced intestinal injury and its molecular mechanism in weaned pigs. Fifty-four pigs (21 days age) were randomly allocated CON, LPS, LPS+CAT groups. CON LPS groups fed a basal diet, whereas group diet with 2,000 mg/kg CAT supplementation for 35 days. On day 36, six selected each group, administered (50 μg/kg body weight). Meanwhile, was injected an...

The objective of this experiment was to determine whether changing the dietary neutral detergent fiber (NDF)/starch ratio affected caecal microbiota when 4 different diets (diet A: 2.3 NDF/starch, diet B: 1.9, C: 1.4, D: 1.0) were formulated. A total 200 weaned rabbits (35 days old, 50 per group) used for experiment, which started after an adaptation period 7 (i.e., day 42). Caecal contents obtained from fed NDF/starch at 52, 62, 72, and 82 life. bacterial community structure characterized...

The present study was conducted to investigate the effect of copper supplementation on lipid metabolism in rabbits. Our showed dietary addition (5-45 mg/kg) increased body mass gain, but decreased fat and liver weights compared with those control group (P < 0.05). Copper (45 significantly skeletal muscle weight, inhibited cytoplasmic accumulation liver, adipose tissue Compared group, plasma triglyceride levels very low density lipoprotein treatment gene expression carnitine...

An experiment was conducted to investigate the effect of acetate treatment on lipid metabolism in rabbits. New Zealand Rabbits (30 days, n=80) randomly received a subcutaneous injection (2 ml/injection) 0, 0.5, 1.0 or 2.0 g/kg per day body mass (dissolved saline) for 4 days. Our results showed that induced dose-dependent decrease shoulder adipose (P0.05), significantly decreased plasma adiponectin, insulin and triglyceride concentrations (P<0.05). In adipose, up-regulated gene expression...

Copper serves as a co-factor for host of metalloenzymes, particularly cytochrome c oxidase (COX). Although it is known that impaired COX function can lead to the excessive accumulation reactive oxygen species (ROS), mechanisms underlying how copper depletion leads cell damage are poorly understood. Here, we have investigated role during ferroptosis. The bathocuproinedisulfonic (BCS) treatment depolarized mitochondrial membrane potential, increased total cellular ROS levels, stimulated...

The objective of this study was to explore the effects dietary iron (Fe) levels on production performance, nutrient digestibility, blood biochemistry, and meat fur quality growing Rex rabbits. Two hundred 3-month-old rabbits were randomly allocated five groups, each with forty replicates. Rabbits fed a basal diet supplemented varying Fe (0, 20, 40, 80, 160 mg/kg) in form ferrous sulfate monohydrate. analyzed concentrations diets 8.2, 25.4, 49.1, 85.6, 178.7 mg/kg, respectively. Over 35-day...

Three experiments were conducted to investigate the effects of grape seed proanthocyanidin extract (GSPE) on growth performance weaned Hyla rabbits and explore its protective against oxidative stress in liver intestine by establishing a hydrogen peroxide (H2O2)-induced model. In Exp.1, ninety-six used evaluate dietary GSPE level performance, results showed that 400 mg/kg addition increased feed conversion ratio coefficient promoted cholesterol metabolism. Exp.2 was H2O2 concentration...

This study furnishes insights into how methionine mitigates heat-stress-induced impairments in hair follicle development Rex rabbits at the cellular level. Dermal papilla cells from dorsal skin of were isolated, cultured vitro, and divided six groups, i.e., control (37 °C; 0 mM methionine), heat stress (45 + 15 mM, 30 45 60 with replicates per group. The groups exposed to °C, 5% CO2, 95% humidity for min, followed by recovery 37 repeated three times over days. On third day, samples collected...

The aim of study was to investigate the effects dark environment on production performance, intestinal barrier function and clock-related gene expression in rabbits. Forty weaned rabbits with similar body weight (35-day-old) were randomly divided into 2 treatments (20 replicates per treatment, 1 rabbit replicate: normal light group (12 L 12 D) or total (24 D). experimental period lasted for 10 days, an adaptation 3 days a subsequent formal 7 days. results showed that feed-to-weight ratio...

The present study was conducted to investigate the effect of Artemisia argyi on production performance and intestinal barrier rabbits. Weaned Hyla rabbits (30 d, n = 160) similar body weight were divided into 4 groups (40 per treatment), they fed a control diet or an experimental supplemented with 3%, 6%, 9% A. argyi. results showed that dietary supplementation did not affect rabbits' food intake gain regardless inclusion level but decreased diarrhea rate index (P < 0.05). Dietary addition...

Abstract Wnt signaling plays an important role in the growth and development of hair follicles (HFs). Among molecules, Wnt10b was shown to promote differentiation primary skin epithelial cells toward shaft inner root sheath HF mice vitro. Whisker HFs were isolated from Rex rabbits cultured vitro measure growth. Meanwhile, dermal papilla (DPCs) Treatment with AdWnt10b or Wnt/β-Catenin Pathway inhibitor, XAV939, assessed DPCs proliferation by CCK-8 assay. And cell cycle also analyzed flow...

This study was conducted to investigate the impacts of chlorogenic acid (CGA) on growth performance, intestinal permeability, digestion and absorption-related enzyme activities, immune responses, antioxidant capacity cecum microbial composition in weaned rabbits. One hundred sixty rabbits were allotted four treatment groups fed with a basal diet or supplemented 400, 800, 1,600 mg/kg CGA, respectively. After 35-d trial, 800 CGA-supplemented group had higher (p < 0.05) ADG lower F/G than those...

Abnormal mutations in the microbial structure of early-weaning mammals are an important cause enteritis. Based on multiple known beneficial functions butyrate, we hypothesized that butyrate would alleviate imbalance intestinal homeostasis induced by early weaning animals. However, mechanisms action between and microbes still poorly explored. In this study, aimed to investigate whether exerts effects flora weanling rabbits their homeostasis, growth development, attempted elucidate potential...

Overexpression of chloroplastic glycerol-3-phosphate acyltransferase gene (LeGPAT) in tomato increased cis-unsaturated fatty acid content phosphatidylglycerol (PG) thylakoid membrane. By contrast, suppressing the expression LeGPAT decreased PG. Under salt stress, sense transgenic plants exhibited higher activities antioxidant enzymes, lower reactive oxygen species (ROS) and less ion leakage compared with wild type (WT) plants. The net photosynthetic rate (P N) maximal photochemical...

Summary The objective of this experiment was to investigate the effect Lactobacillus isolates on intestinal bacterial community composition growing Rex Rabbits. A total 120 weaned Rabbits (30 days old, 30 per group) were used for experiment, which started after an adaptation period 7 days. control group fed with basal diet only, while treatment I, II and III groups adding antibiotics, zeae ( LB 1) casei (L3) respectively. Growth performance, immune response flora have been examined. results...

Weanling rabbits frequently exhibit diarrhea or flatulence. Our experiment was conducted to investigate the effect of garlic straw on performance and intestinal barrier rabbits. Hyla (60 d, n = 160) with similar body weight were divided into 4 groups (4 replicates per group 10 replicate): fed a basal diet (control) an experimental 5%, 10%, 15% powder supplement. The results showed that dietary addition increased significantly average daily gain feed intake. Compared control, 10% decreased...

Dermal papilla cells (DPCs) play important roles in hair growth regulation. However, strategies to regrow are lacking. Here, global proteomic profiling identified the tetrathiomolybdate (TM)-mediated inactivation of copper (Cu) depletion-dependent mitochondrial cytochrome c oxidase (COX) as primary metabolic defect DPCs, leading decreased Adenosine Triphosphate (ATP) production, membrane potential depolarization, increased total cellular reactive oxygen species (ROS) levels, and reduced...

Deoxynivalenol (DON) is a potential pathogenic factor to humans and animals, intestinal tract the primary target organ of DON. Data concerning effects DON on rabbits are scarce, especially for weaning rabbits. In this study, 45 (35 d) were randomly equally assigned into three groups. Group A was fed basic diet, while groups B C added at 0.5 mg/kg BW/d 1.5 BW/d, respectively, based diet. The experiment lasted 24 days morphology, expression, distribution several cytokines in segments have been...

To investigate the effects of heat stress on meat rabbits, we assigned 80 rabbits to moderate temperature group (24 ± 1°C; Control group) and continuous high-temperature (HT group), then monitored using growth performance, carcass characteristics, biochemical assays, UPLC-MS/MS-based metabolomics, microbiome. The results showed that after exposure, average daily gain, feed intake, thymus index were significantly decreased (p < 0.05). Contents HSP70, ALP, Cortisol in serum increased, while...

There is still a lack of longitudinal dynamic studies on the taxonomic features, functional reserves, and metabolites rabbit gut microbiome. An experiment was conducted to characterize bacterial community rabbits. By combining metagenomics metabolomics, we have comprehensively analyzed dynamics microbiota its effect host adaptability. Our data reveal an overall increasing trend in microbial gene diversity richness during pre-harvest lifespan The introduction solid feed important driving...

Abstract This study investigated the protective effects of chlorogenic acid (CGA) on production performance and liver function rabbits under heat stress (HS) condition. A total 120 healthy New Zealand weaned with similar initial body weight, were randomly divided into 3 treatments 20 replicates per treatment 2 replicate: control (CON) group (rabbits housed at 25 ± 1°C fed a basal diet), HS 35 + CGA diet supplemented 800 mg/kg CGA). The trial lasted for 28 days. results showed that challenge...