A5040619778- interferon and immune responses
- Immune Response and Inflammation
- Viral Infections and Vectors
- MicroRNA in disease regulation
- Fire effects on ecosystems
- Pancreatitis Pathology and Treatment
- Orthopaedic implants and arthroplasty
- NF-κB Signaling Pathways
- Fire Detection and Safety Systems
- Total Knee Arthroplasty Outcomes
- AI in cancer detection
- Animal Virus Infections Studies
- Hip and Femur Fractures
- Esophageal Cancer Research and Treatment
- Video Surveillance and Tracking Methods
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Phagocytosis and Immune Regulation
- Cytokine Signaling Pathways and Interactions
- Surgical Sutures and Adhesives
- Endoplasmic Reticulum Stress and Disease
- Digital Imaging for Blood Diseases
- Intestinal and Peritoneal Adhesions
- Cancer Immunotherapy and Biomarkers
Southern Medical University
2019-2025
Zhejiang University of Science and Technology
2024-2025
Union Hospital
2025
Huazhong University of Science and Technology
2025
Shanghai Sixth People's Hospital
2025
Fujian Medical University
2025
Wuhan Union Hospital
2024
Heilongjiang Provincial Hospital
2022-2023
Tencent (China)
2023
Huaian First People’s Hospital
2022
Forest is an important resource for human survival, and forest fires are a serious threat to protection. Therefore, the early detection of fire smoke particularly important. Based on manually set feature extraction method, accuracy machine learning method limited, it unable deal with complex scenes. Meanwhile, most deep methods difficult deploy due high computational costs. To address these issues, this paper proposes lightweight model based YOLOv8 (FFYOLO). Firstly, in order better extract...
Lysosomes is emerging as a promising therapeutic target for improving immunotherapy, which dysfunction would trigger lysosomal membrane permeabilization increase and subsequent leakage of reduced iron, contributed to ferroptosis through cell-intrinsic Fenton chemistry. However, the integrity membranes not susceptible disrupt, owing presence several Endo-lysosomal damage-response mechanisms. Herein, we developed lysosome-targeted photosensitizer (TLA), possessed robust light stability, good...
Background Handedness refers to the lateral preference of using one hand more than other. Surgeon handedness has been widely discussed in operative surgery and could cause clinical discrepancy. However, use proximal femoral nail antirotation (PFNA) for treatment intertrochanteric femur fracture (IFF), effect on outcomes is easily overlooked. In fact, when right-handed surgeons operate right-sided IFF patients, due specific nature surgical site, they have their left perform opening at end...
Forest fires have a great destructive impact on the Earth’s ecosystem; therefore, top priority of current research is how to accurately and quickly monitor forest fires. Taking into account efficiency cost-effectiveness, deep-learning-driven UAV remote sensing fire detection algorithms emerged as favored trend seen extensive application. However, in process drone monitoring, often appear very small are easily obstructed by trees, which greatly limits amount effective information that can...
The current study aimed to develop a deep learning (DL) model for prediction of lymph node metastasis (LNM) based on hematoxylin and eosin (HE)-stained histopathological images endometrial cancer (EC). was validated using external data.A total 2,104 whole slide image (WSI) from 564 patients with pathologically confirmed LNM status were collated West China Second University Hospital. An artificial intelligence (AI) built the multiple instance-learning (MIL) framework automatic probability its...
The threat of forest fires to human life and property causes significant damage society. Early signs, such as small smoke, are often difficult detect. As a consequence, early detection smoke is crucial. Traditional fire models have shortcomings, including low accuracy efficiency. YOLOv8 model exhibits robust capabilities in detecting smoke. However, it struggles balance accuracy, complexity, speed. This paper proposes LD-YOLO, lightweight dynamic based on the YOLOv8, detect Firstly,...
Survival prediction of esophageal cancer is an essential task for doctors to make personalized treatment plans. However, handcrafted features from medical images need prior knowledge, which usually limited and not complete, yielding unsatisfying survival predictions. To address these challenges, we propose a novel efficient deep learning-based framework evaluating clinical outcomes before concurrent chemoradiotherapy. The proposed model consists two key components: 3D Coordinate Attention...
Peritoneal adhesion is the most common adverse effect following abdominal surgery or inflammation. The occurrence in clinical trials has been successfully reduced using barriers. However, shortcomings of frequently used barriers, such as rapid degradation rate gel barrier and inadequate operation ability solid barrier, cannot be ignored. In this study, a fibrous membrane with an ECM-like structure was prepared. properties were significantly by changing surface structure. caused less...
Chickens are the natural host of Newcastle disease virus (NDV) and avian influenza (AIV). The discovery that RIG-I gene, primary RNA pattern recognition receptor (PRR) in mammals, is naturally absent chickens has directed attention to studies chicken PRRs their functions antiviral immune responses. Here, we identified Asp-Glu-Ala-Asp (DEAD)-box helicase 1 (DDX1) as an essential PRR investigated its anti-RNA viral infections. chDDX1 gene was cloned, cross-species sequence alignment...
Bats are important hosts for various zoonotic viral diseases. However, they rarely show signs of disease infection with such viruses. As the first line virus control, innate immune system bats attracted our full attention. In this study, Tadarida brasiliensis MDA5 gene (batMDA5), a major sensor anti-RNA infection, was cloned, and its biological functions in antiviral immunity were identified. Bioinformatics analysis shows that amino acid sequence batMDA5 is poorly conserved among species, it...
Abstract Innate immunity plays an essential role in preventing the invasion of pathogenic microorganisms. However, innate is a double-edged sword, whose excessive activation detrimental to immune homeostasis and even leads “cytokine storm” infected host. The host develops series negative regulatory mechanisms balance response. Here, we report mechanism chicken mediated by miRNA. In GEO database, found that miR-126-5p was markedly up-regulated chickens RNA viruses. Upregulation virus then...
Background The prognosis for advanced intrahepatic cholangiocarcinoma (iCCA) is poor, and there remains an urgent need to develop efficient systemic therapy. efficacy of Pembrolizumab immunotherapy combined with lenvatinibin in iCCA still unclear. role Epstein–Barr-virus (EBV) as a biomarker response needs further exploration.
Interferon regulatory factors (IRFs) play a key role in many aspects of immune response, and IRF1, IRF3, IRF7 are positive regulators IFN induction mammals. However, as the most critical factor mammals, is naturally absent birds, which attracts us to study functions other members avian IRF family. In present study, we cloned goose IRF1 (GoIRF1) conducted series bioinformatics analyses compare protein homology GoIRF1 with that species. The overexpression DF-1 cells induced activation IFN-β,...
Stimulator of the interferon gene (STING) is involved in mammalian antiviral innate immunity as an (IFN) activator. However, there still a lack clarity regarding molecular characterization goose STING (GoSTING) and its role immune response. In present study, we cloned GoSTING performed series bioinformatics analyses. was grouped into avian clades showed highest sequence similarity to duck STING. The vitro experiments that mRNA levels GoSTING, IFNs, IFN-stimulated genes (ISGs),...
The mammalian-derived MDCK cells are the most widely used for avian virus vaccine production at present. use of heterologous cell systems preparation may cause security risks. An line is available vaccines urgently needed. In this study, a peacock immortalized fibroblast that suitable was generated. primary were prepared, and immortal PEF-1 obtained by transferring hTERT into screening with G418. has high viability expresses exogenous TERT protein. More importantly, replication ability...
To determine whether the two lower extremities are of equal length after hip arthroplasty for femoral neck fractures, we developed a novel method manual positioning based on anatomical mark (shoulder-to-shoulder) in arthroplasty. Patients with fractures requiring from July 2020 to March 2022 orthopedic department Jinjiang Municipal Hospital, Fujian Province, China were recruited. Hip was performed using proposed "shoulder-to-shoulder" 52 patients who met inclusion criteria....
OBJECTIVE To compare the accuracy of three methods for measuring length both lower limbs in hip arthroplasty femoral neck fracture elderly, and to introduce a shoulder anatomical location marking method femur. METHODS From January 2017 2019, 90 elderly patients with were treated replacement, including 39 males 51 females, aged 65 96(78.0±7.4) years, 56 cases total 34 hemi hip. According garden classification, there 7 typeⅡ, 63 type Ⅲ 20 Ⅳ. The divided into groups according different...
Background: Acute pancreatitis is a severe pancreatic disorder that remains associated with high mortality due to lack of effective drugs and management strategies. This study aimed investigate the molecular pathogenic mechanisms acute involving p53 endoplasmic reticulum (ER) stress pathways.Methods: Expression PRSS1 in human tissues was detected by immunohistochemistry western blotting. induced caerulein humanized transgenic mice, its severity verified histological imaging, evaluation...