A5103084424- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Folate and B Vitamins Research
- Cancer-related Molecular Pathways
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA modifications and cancer
- Time Series Analysis and Forecasting
- MicroRNA in disease regulation
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Congenital heart defects research
- Dysphagia Assessment and Management
- Corneal Surgery and Treatments
- Hippo pathway signaling and YAP/TAZ
- Phonocardiography and Auscultation Techniques
- Drug-Induced Ocular Toxicity
- Genetic Syndromes and Imprinting
- Tissue Engineering and Regenerative Medicine
- Cancer-related gene regulation
- Esophageal and GI Pathology
- Biomedical and Engineering Education
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Diet, Metabolism, and Disease
Zhejiang University
2021-2023
Affiliated Hospital of North Sichuan Medical College
2023
Fudan University
2022
Ministry of Education of the People's Republic of China
2020-2021
Second Affiliated Hospital of Zhejiang University
2020-2021
Hangzhou Dianzi University
2014
Central South University
2009-2010
Second Xiangya Hospital of Central South University
2010
R-loops, three-stranded DNA-DNA:RNA hybrid structures, are best known for their deleterious effects on genome stability. The regulatory factors of this fundamental genetic structure remain unclear. Here, we reveal an epigenetic factor that controls R-loop METTL8, a member the methyltransferase-like protein family methylates 3-methylcytidine (m3C), is key in regulating methyltransferase complex. Biochemical studies show METTL8 forms large SUMOylated nuclear RNA-binding complex (∼0.8 mega...
Abstract Lactic acidosis is a feature of solid tumors and plays fundamental role(s) rendering cancer cells to adapt diverse metabolic stresses, but the mechanism underlying its roles in redox homeostasis remains elusive. Here we show that G6PD phosphorylated at tyrosine 249/322 by SRC through formation GSTP1-G6PD-SRC complex. acid attenuates this phosphorylation non-covalently binding with GSTP1. Furthermore, lactic increases activity facilitates PPP (NADPH production) sensor GSTP1, thereby...
Urea is largely derived from the urea cycle reactions through hepatic detoxification of free ammonia and cleared by urination, serum level a crucial medical indicator for measuring kidney function in patients with nephropathy; however, investigative revelations pointing to as risk factor cancer are very scarce, relevant studies restricted potential biases. We aimed explore causal relationships development focusing on renal cell carcinoma (RCC) using Mendelian randomization (MR) analyses....
Abstract Background Respectively, prostate cancer (PCa) and breast (BC) are the second most commonly diagnosed in men women, they account for a majority of cancer-related deaths world-wide. Cancer cells typically exhibit much-facilitated growth that necessitates upregulated glycolysis augmented amino acid metabolism, glutamine aspartate particular, which is tightly coupled with an increased flux tricarboxylic (TCA) cycle. Epidemiological studies have exploited metabolomics to explore...
Background: Aberrant homocysteine level is associated with metabolic disorders and DNA damage, which may be involved in the carcinogenesis of hormone-related cancers, but clinical results observational studies are controversial. In this study, we investigated causal relationships between plasma breast cancer (BRCA), prostate (PrCa), renal cell carcinoma (RCC) using Mendelian randomization (MR) analyses. Design Methods: To investigate putative associations aforementioned three types a...
Breast cancer is the most common worldwide. Low DNAJB4 expression levels are strongly correlated with poor prognosis in breast patients. However, molecular mechanism by which regulates progression unclear.The of was validated human tissues, normal and cell lines. CCK-8, colony-forming, wound healing assays were used to assess biological effect overexpression on proliferation migration MCF-7 Bioinformatic analysis identify related pathways cancer. Epithelial-mesenchymal transition...
Background: Since the association of homocysteine and clinical results observational studies are controversial on non-alcoholic fatty liver related disease, we compute two-sample Mendelian Randomization (MR) study. Objective: To evaluate whether plasma level has an effect risk Non-alcoholic disease (NAFLD), steatohepatitis (NASH), Cirrhosis after its progress, investigated causal relationships between three diseases mentioned above. Design methods: Summary estimates were elicited from...
Background Observational studies indicate that phospholipid fatty acids (FAs) have an impact on the etiology in cancers, but results are conflicting. We aimed to investigate causal association of FAs with breast cancer and prostate cancer. Methods Fourteen single nucleotide polymorphisms (SNPs) were selected as instrumental variables predict level 10 from Genome-wide (GWAS). obtained summary statistics for latest largest GWAS datasets (113,789 controls 133,384 cases) (61,106 79,148 Breast...