A5100431975- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Protein Tyrosine Phosphatases
- Mesenchymal stem cell research
- Neurogenesis and neuroplasticity mechanisms
- RNA Research and Splicing
- interferon and immune responses
- Bone Metabolism and Diseases
- Autophagy in Disease and Therapy
- Cancer Cells and Metastasis
- PARP inhibition in cancer therapy
- Berberine and alkaloids research
- Metabolism, Diabetes, and Cancer
- Electrospun Nanofibers in Biomedical Applications
- Glioma Diagnosis and Treatment
Poultry Research Institute
2021
Shandong Academy of Agricultural Sciences
2021
Tianjin University
2020
Union Hospital
2016-2019
Huazhong University of Science and Technology
2016-2019
Zhengzhou Children's Hospital
2019
Zhengzhou University
2019
Air Force Medical University
2018
Xijing Hospital
2018
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2017
Our recent study showed that miR-2861 promotes osteoblast differentiation by targeting histone deacetylase 5, resulting in increased runt-related transcription factor 2 (Runx2) protein production. Here we identified another new microRNA (miRNA) (miR-3960) played a regulatory role through feedback loop with miR-2861. miR-3960 and were found clustered at the same loci. was transcribed during bone morphogenic (BMP2)-induced osteogenesis of ST2 stromal cells. Overexpression promoted BMP2-induced...
Activation of AMP-activated protein kinase (AMPK) could potently protect osteoblasts/osteoblastic cells from dexamethasone (Dex). We aim to induce AMPK activation via microRNA ("miRNA") downregulation its phosphatase Ppm1e. discovered that microRNA-135b ("miR-135b") targets the 3' untranslated regions (UTRs) In human osteoblasticOB-6 and hFOB1.19 cells, forced-expression miR-135b downregulated Ppm1e activated signaling. also protected osteoblastic Dex. shRNA-induced knockdown similarly...
Abstract The accurate generation of an appropriate number different neuronal and glial subtypes is fundamental to normal brain functions requires tightly orchestrated spatial temporal developmental programmes maintain the balance between proliferation differentiation neural progenitor cells. However, molecular mechanism governing this process has not been fully elucidated. Here, we found that miR-214-3p was highly expressed in cells dynamically regulated during neocortical development....
Cell apoptosis induced by Angiotensin II (Ang II) has a critical role in the development of cardiovascular diseases. The aim present study was to investigate whether sanguinarine (SAN), drug which proved have anti‑oxidant, anti‑proliferative and immune enhancing effects, can abolish cell Ang II. In study, H9c2 cardiac cells were stimulated with 10 µM or without SAN. level intracellular reactive oxygen species (ROS) generation assessed using dichlorodihydrofluorescein diacetate, changes...
MicroRNAs (miRNAs/miRs) are a class of small noncoding RNA molecules that have important roles in regulating the expression target genes associated with development and progression cancer. The majority miRNAs expressed highly tissue- region-specific manner, released into bloodstream as consequences different diseases. Furthermore, altered levels been observed several diseases, including In present study, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) demonstrated...
Abstract Background miRNAs play critical roles in growth and development. Various studies of chicken muscle development have focused on identifying that are important for embryo or adult However, little is known about the role whole process from embryonic to post-hatching periods. Here, we present a comprehensive investigation miRNA transcriptomes at 12-day (E12), E17, day 1 (D1), D14, D56 D98 stages. Results We identified 337 differentially expressed (DE-miRNAs) during A Short Time-Series...
Numerous studies have demonstrated that microRNAs (miRNAs or miRs) are abnormally expressed in retinoblastoma (RB). miRNAs may serve a role oncogene tumor-suppressor activity RB genesis and development by modulating various biological processes. therefore, be effective therapeutic targets for miRNA-based therapy patients with RB. Recently it has been revealed miR-503 types of human cancer. However, the expression functional roles rarely reported In current study, was significantly...
To study the effects of miR-221 on biological activity childhood acute lymphoblastic leukemia cells and its mechanism.Bone marrow mononuclear (BMNC) were isolated from bone samples ALL children diagnosed in our hospital May 2018 to November 2018. The divided into control group, miR-221-NC group group. After transfection according instructions Lipofectamine 2000 kit, levels each detected by RT-PCR. Flow cytometry was used detect cell cycle apoptosis. Transwell assay migration invasion....
Objective: To investigate the effect of nanoscale zirconium-porphyrin metal-organic framework (NPMOF) on development nervous system in larval zebrafish. Methods: Embryos zebrafish were incubated to E3 medium (n=500) or 100 mg/L NPMOF-E3 from 6 hours post fertilization (hpf) 28, 48, 72, 96 120 hpf. At and hpf, 60 fish collected respectively for quantitative real-time PCR both groups. 20 used situ hybridization, 150 immunofluorescence 30 behavioral test, respectively. The shape size NPMOF was...